Patents by Inventor Bernhard Kreymann
Bernhard Kreymann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11833282Abstract: Described herein is a process suitable for extracorporeal lung support that relies on exposing blood, separated by a semipermeable membrane from the dialysis liquid. The dialysis liquid comprises a buffering agent and has a high buffering capacity for H+ ions. Carbon dioxide, bicarbonate and hydrogen cations can be efficiently transported across a semipermeable membrane to the dialysis liquid. This also allows for the regeneration and recycling of the dialysis liquid, and thus for its repeated use. The versatility of the dialysis liquid allows adjusting the pH of the dialysis liquid, add fluids to the dialysis liquid and/or to the blood in the extracorporeal circuit and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. Thus, the process is versatile, and suitable for treating or preventing respiratory acidosis, metabolic acidosis, diseases associated with lung malfunction and/or kidney malfunction and/or liver malfunction.Type: GrantFiled: April 27, 2022Date of Patent: December 5, 2023Assignee: Advitos GmbHInventors: Bernhard Kreymann, Christoph Hüßtege
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Patent number: 11583620Abstract: The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid.Type: GrantFiled: November 18, 2016Date of Patent: February 21, 2023Assignee: Advitos GmbHInventors: Bernhard Kreymann, Christoph Hüßtege
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Publication number: 20220249753Abstract: Described herein is a process suitable for extracorporeal lung support that relies on exposing blood, separated by a semipermeable membrane from the dialysis liquid. The dialysis liquid comprises a buffering agent and has a high buffering capacity for H+ ions. Carbon dioxide, bicarbonate and hydrogen cations can be efficiently transported across a semipermeable membrane to the dialysis liquid. This also allows for the regeneration and recycling of the dialysis liquid, and thus for its repeated use. The versatility of the dialysis liquid allows adjusting the pill of the dialysis liquid, add fluids to the dialysis liquid and/or to the blood in the extracorporeal circuit and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs. Thus, the process is versatile, and suitable for treating or preventing respiratory acidosis, metabolic acidosis, diseases associated with lung malfunction and/or kidney malfunction and/or liver malfunction.Type: ApplicationFiled: April 27, 2022Publication date: August 11, 2022Applicant: Advitos GmbHInventors: Bernhard Kreymann, Christoph Hüßtege
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Patent number: 11351291Abstract: The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed.Type: GrantFiled: March 14, 2016Date of Patent: June 7, 2022Assignee: ADVITOS GMBHInventors: Bernhard Kreymann, Christoph Huesstege, Catherine Elisabeth Schreiber
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Patent number: 11344656Abstract: Systems and methods suitable for extracorporeal lung support are provided that expose blood, across a semipermeable membrane, to a dialysis liquid. The dialysis liquid features a buffering agent and has a high buffering capacity for H+ ions. Carbon dioxide, bicarbonate and hydrogen cations are transported across a semipermeable membrane into the dialysis liquid. The dialysis fluid may be recycled and repeatedly used, and its pH may be adjusted, and other fluids added to it. Certain substances may be removed from the blood, and the amount of these substances removed from the blood may be substantially automatically or substantially continuously monitored or quantified. The systems and methods are suitable for treating or preventing respiratory acidosis, metabolic acidosis, and diseases featuring lung malfunction, kidney malfunction, or liver malfunction.Type: GrantFiled: May 22, 2018Date of Patent: May 31, 2022Assignee: ADVITOS GMBHInventors: Bernhard Kreymann, Christoph Hüsstege
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Publication number: 20210100941Abstract: The present invention provides compositions which can be used to treat a carrier protein-containing multiple pass dialysis fluid in particular in order to ensure regeneration of a carrier protein such as albumin in the dialysis fluid. The invention further relates to kits comprising such compositions and uses thereof as well as to methods for providing and regenerating a carrier protein-containing multiple pass dialysis fluid.Type: ApplicationFiled: March 28, 2017Publication date: April 8, 2021Applicant: ADVITOS GMBHInventors: Bernhard KREYMANN, Christoph HÜSSTEGE
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Publication number: 20200164127Abstract: Systems and methods suitable for extracorporeal lung support are provided that expose blood, across a semipermeable membrane, to a dialysis liquid. The dialysis liquid features a buffering agent and has a high buffering capacity for H+ ions. Carbon dioxide, bicarbonate and hydrogen cations are transported across a semipermeable membrane into the dialysis liquid. The dialysis fluid may be recycled and repeatedly used, and its pH may be adjusted, and other fluids added to it. Certain substances may be removed from the blood, and the amount of these substances removed from the blood may be substantially automatically or substantially continuously monitored or quantified. The systems and methods are suitable for treating or preventing respiratory acidosis, metabolic acidosis, and diseases featuring lung malfunction, kidney malfunction, or liver malfunction.Type: ApplicationFiled: May 22, 2018Publication date: May 28, 2020Inventors: Bernhard KREYMANN, Christoph HÜSSTEGE
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Publication number: 20190192757Abstract: The invention provides a method and an apparatus or system for dialysis. The method and apparatus or system are useful for removing an undesirable protein-binding substance such as a toxin from a biological fluid such as blood or blood plasma. As such, the method and apparatus or system are useful for treating a subject in need of dialysis such as a subject suffering from hepatic disease. The methods feature a) dialyzing a biological fluid against a dialysis fluid containing an adsorber for a protein-binding substance to be removed through a semipermeable membrane, b) adjusting the dialysis fluid so that the binding affinity of the adsorber for the protein-bound substance to be removed is lowered and the substance to be removed passes into solution, and c) balancing the volume or flow of one or more fluids in the apparatus or system suitable for dialyzing a biological fluid containing a protein-binding substance to be removed.Type: ApplicationFiled: March 14, 2016Publication date: June 27, 2019Inventors: Bernhard KREYMANN, Christoph HUESSTEGE, Catherine Elisabeth SCHREIBER
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Publication number: 20190030232Abstract: The present invention generally relates to a process suitable for extracorporeal lung support. The process comprises contacting blood with a dialysis liquid separated by a semipermeable membrane. Oxygen is introduced into blood and/or into the dialysis liquid prior to contacting blood and dialysis liquid being separated by the semipermeable membrane. The process is versatile and allows for blood oxygenation as well as removal of at least one undesired substance occurring in the blood, selected from carbon dioxide, bicarbonate and hydrogen cations, from blood. Thereby, the present invention takes advantage of the Haldane effect in the extracorporeal contacting step. The undesired substance can be efficiently transported across a semipermeable membrane to the dialysis liquid.Type: ApplicationFiled: November 18, 2016Publication date: January 31, 2019Applicant: Hepa Wash GmbHInventors: Bernhard Kreymann, Christoph Hüßtege
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Publication number: 20190015574Abstract: The present invention generally relates to a process suitable for extracorporeal lung support. The process relies on exposing blood, separated by a semipermeable membrane from the dialysis liquid. The dialysis liquid of the present invention comprises a buffering agent and has a high buffering capacity for H* ions. Carbon dioxide, bicarbonate and hydrogen cations can be efficiently transported across a semipermeable membrane to the dialysis liquid. The present invention also allows for the regeneration and recycling of the dialysis liquid, and thus for its recycling and repeated use. The versatility of the dialysis liquid allows to adjust the pH of the dialysis liquid, add fluids to the dialysis liquid and/or to the blood in the extracorporeal circuit and to remove substances from the blood in the extracorporeal circuit, depending on the conditions and needs.Type: ApplicationFiled: November 18, 2016Publication date: January 17, 2019Applicant: Hepa Wash GmbHInventors: Bernhard Kreymann, Christoph Hüßtege
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Patent number: 9039896Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.Type: GrantFiled: June 6, 2013Date of Patent: May 26, 2015Assignee: Hepa Wash GmbHInventor: Bernhard Kreymann
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Patent number: 8574438Abstract: A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path.Type: GrantFiled: January 11, 2013Date of Patent: November 5, 2013Assignee: Hepa Wash GmbHInventors: Bernhard Kreymann, Catherine Elisabeth Schreiber, Ahmed Nabeel Al-Chalabi
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Patent number: 8480899Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.Type: GrantFiled: October 22, 2008Date of Patent: July 9, 2013Assignee: Hepa Wash GmbHInventor: Bernhard Kreymann
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Publication number: 20130118979Abstract: A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path.Type: ApplicationFiled: January 11, 2013Publication date: May 16, 2013Applicant: HEPA WASH GMBHInventors: Bernhard Kreymann, Catherine Elisabeth Schreiber, Ahmed Nabeel Al-Chalabi
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Patent number: 8377308Abstract: A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalized dialysate flowing in the second flow path.Type: GrantFiled: December 3, 2007Date of Patent: February 19, 2013Assignee: Hepa Wash GmbHInventors: Bernhard Kreymann, Catherine Elisabeth Schreiber, Ahmed Nabeel Al-Chalabi
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Publication number: 20100258503Abstract: A dialysate regeneration unit adapted for regenerating a dialysate containing carrier substances comprises a first flow path and a second flow path. The first flow path comprises a first supply unit adapted for adding an acidic fluid to the dialysate flowing in the first flow path, and a detoxification unit located downstream of the first supply unit. The detoxification unit is adapted for removing toxins from the acidified dialysate flowing in the first flow path. The second flow path extends in parallel to the first flow path. The second flow path comprises a second supply unit adapted for adding an alkaline fluid to the dialysate flowing in the second flow path, and a further detoxification unit located downstream of the second supply unit. The further detoxification unit is adapted for removing toxins from the alkalised dialysate flowing in the second flow path.Type: ApplicationFiled: December 3, 2007Publication date: October 14, 2010Inventors: Bernhard Kreymann, Catherine Elisabeth Schreiber, Ahmed Nabeel Al-Chalabi
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Publication number: 20090120876Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.Type: ApplicationFiled: October 22, 2008Publication date: May 14, 2009Inventor: Bernhard Kreymann
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Patent number: 7455771Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.Type: GrantFiled: November 4, 2004Date of Patent: November 25, 2008Assignee: Hepa Wash GmbHInventor: Bernhard Kreymann
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Publication number: 20050082225Abstract: The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.Type: ApplicationFiled: November 4, 2004Publication date: April 21, 2005Inventor: Bernhard Kreymann