Patents by Inventor Bernhard Lesch

Bernhard Lesch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II
    Patent number: 9802947
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 31, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Antonio Nardi, Paul Ratcliffe, Tobias Craan, Torsten Hertrampf, Bernhard Lesch, Henning Steinhagen
  • Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II
    Patent number: 9771359
    Abstract: The invention relates to oxazole and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: September 26, 2017
    Assignee: Medifron DBT Inc.
    Inventors: Robert Frank-Foltyn, Christopher Habermann, Gregor Bahrenberg, Bernhard Lesch, Nils Damann, Klaus Schiene, Hannelore Stockhausen, Thomas Christoph, Sven Frormann, Derek Saunders, Jeewoo Lee
  • Substituted Oxazole- and Thiazole-Based Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands II
    Publication number: 20170253586
    Abstract: The invention relates to oxazole and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: May 23, 2017
    Publication date: September 7, 2017
    Inventors: Robert FRANK-FOLTYN, Christopher HABERMANN, Gregor BAHRENBERG, Bernhard LESCH, Nils DAMANN, Klaus SCHIENE, Hannelore STOCKHAUSEN, Thomas CHRISTOPH, Sven FRORMANN, Derek SAUNDERS, Jeewoo LEE
  • 3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I
    Patent number: 9725459
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 8, 2017
    Assignee: GRUNENTHAL GMBH
    Inventors: Antonio Nardi, Paul Ratcliffe, Tobias Craan, Torsten Hertrampf, Bernhard Lesch, Robert Kime, Henning Steinhagen
  • Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Patent number: 9624209
    Abstract: Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: April 18, 2017
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank-Foltyn, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Derek Saunders, Hannelore Stockhausen
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I
    Publication number: 20150307507
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ANTONIO NARDI, PAUL RATCLIFFE, TOBIAS CRAAN, TORSTEN HERTRAMPF, BERNHARD LESCH, ROBERT KIME, HENNING STEINHAGEN
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES II
    Publication number: 20150307506
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Antonio NARDI, Paul RATCLIFFE, Tobias CRAAN, Torsten HERTRAMPF, Bernhard LESCH, Henning STEINHAGEN
  • Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Patent number: 9120756
    Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: September 1, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Derek Saunders, Hannelore Stockhausen
  • Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands
    Patent number: 9029378
    Abstract: Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: May 12, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Thomas Christoph, Bernhard Lesch, Jeewoo Lee
  • Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands
    Publication number: 20150099728
    Abstract: Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions.
    Type: Application
    Filed: December 12, 2014
    Publication date: April 9, 2015
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Nils DAMANN, Sven FRORMANN, Bernhard LESCH, Jeewoo LEE, Yong-Soo KIM, Myeong-Seop KIM, Derek SAUNDERS, Hannelore STOCKHAUSEN
  • Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Patent number: 8946204
    Abstract: Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: February 3, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Derek John Saunders, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Hannelore Stockhausen
  • Aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
    Patent number: 8937092
    Abstract: The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: January 20, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Bernhard Lesch, Jeewoo Lee
  • Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands
    Publication number: 20150011592
    Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Application
    Filed: October 24, 2013
    Publication date: January 8, 2015
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Nils DAMANN, Sven FRORMANN, Bernhard LESCH, Jeewoo LEE, Yong-Soo KIM, Myeong-Seop KIM, Derek SAUNDERS, Hannelore STOCKHAUSEN
  • Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands
    Patent number: 8765733
    Abstract: The invention relates to amine substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 1, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Bernhard Lesch, Jeewoo Lee
  • Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands
    Publication number: 20140142143
    Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Application
    Filed: October 24, 2013
    Publication date: May 22, 2014
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Nils DAMANN, Sven FRORMANN, Bernhard LESCH, Jeewoo LEE, Yong-Soo KIM, Myeong-Seop KIM, Derek SAUNDERS, Hannelore STOCKHAUSEN
  • Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Patent number: 8592471
    Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: November 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Derek Saunders, Hannelore Stockhausen
  • Substituted Heterocyclic Aza Compounds
    Publication number: 20130029961
    Abstract: Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Thomas Christoph, Bernhard Lesch, Jeewoo Lee
  • Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
    Publication number: 20130029995
    Abstract: Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Thomas CHRISTOPH, Bernhard LESCH, Jeewoo LEE
  • Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
    Publication number: 20130029962
    Abstract: Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Bernhard LESCH, Jeewoo LEE
  • Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands
    Patent number: 8334315
    Abstract: The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: December 18, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim