Abstract: The bone substitute material on the base of natural bone is rendered completely free of albumin and antigen by premaceration, pyrolization and sintering and its frame work consists of only the natural mineral structure of the natural bone.In the process of production of this bone substitute material the bone pieces are submitted to a pretreatment with warm water for removing of the soft parts, subsequently takes place a dealbumination by means of a solution of 10 to 30% H.sub.2 O.sub.2 in a shaking machine and a degreasing with ether. The bone pieces treated in this way are subsequently submitted to a combustion in a stove at 400.degree. C. to 1500.degree. C. and then to a sintering.This bone substitute material which may exist in the shape of the bone part to be replaced forms a form stable matrix for the bone regeneration in which only pure "mineral bone" is present so that no immunogen reactions can take place.