Patents by Inventor Bernhard Prager

Bernhard Prager has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 6333409
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: December 25, 2001
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 6136967
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(Z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: October 24, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Process for the purification of a 3-cephem-4-carboxylic acid derivative
    Patent number: 5869648
    Abstract: The invention relates to a new process for the depletion of 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-?(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-?(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-?(Z/E)-1-propen-1-yl!-3-cephem-4-carboxylic acid or by adsorption chromatography.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 9, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Johannes Ludescher, Bernhard Prager, Siegfried Wolf
  • Process for the synthesis of the disodium salt hemiheptahydrate of ceftriaxone
    Patent number: 5574155
    Abstract: The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio] methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: November 12, 1996
    Assignee: BIOCHEMIE Gesellschaft m.b.H.
    Inventors: Johann Danklmaier, Ingolf Macher, Bernhard Prager