Abstract: A horizontal solid-bowl centrifuge with cleaning-in-place jet nozzles for cleaning the bowl in a manner complying with good manufacturing procedure is provided. The bowl is cleaned by a defined arrangement of the cleaning jet nozzles, as the bowl rotates at a speed insufficient to produce a centrifugal force equal to gravitational acceleration, where gravitational acceleration is equal to 1.0 g. The cleaning liquids are then removed after the bowl stops rotating at the lowest point of the bowl.

Abstract: A horizontal solid-bowl centrifuge with cleaning-in-place jet nozzles for cleaning the bowl in a manner complying with good manufacturing procedure is provided. The bowl is cleaned by a defined arrangement of the cleaning jet nozzles, as the bowl rotates at a speed insufficient to produce a centrifugal force equal to gravitational acceleration, where gravitational acceleration is equal to 1.0 g. The cleaning liquids are then removed after the bowl stops rotating at the lowest point of the bowl.

Abstract: A horizontal solid-bowl centrifuge with cleaning-in-place jet nozzles for cleaning the bowl in a manner complying with good manufacturing procedure is provided. The bowl is cleaned by a defined arrangement of the cleaning jet nozzles, as the bowl rotates at a speed insufficient to produce a centrifugal force equal to gravitational acceleration, where gravitational acceleration is equal to 1.0 g. The cleaning liquids are then removed after the bowl stops rotating at the lowest point of the bowl.

Abstract: A horizontal solid-bowl centrifuges with cleaning-in-place jet nozzles for cleaning the bowl in a manner complying with good manufacturing procedure is provided. The bowl is cleaned by a defined arrangement of the cleaning jet nozzles, as the bowl rotates at a speed insufficient to produce a centrifugal force equal to gravitational acceleration, where gravitational acceleration is equal to 1.0 g. The cleaning liquids are then removed after the bowl stops rotating, at the lowest point of the bowl.

Abstract: A process is described for obtaining insulin, which is virtually free from proteases and/or insulin acetylated at position A9, by chromatography in aqueous, buffered solvents which contain water-miscible organic solvents, on lipophilically modified silica gel, wherein the dissolving buffer contains acetone or acetonitrile.

Abstract: A device, consisting of a chromatography column which is closed off at the top by a plunger and, at the bottom, by a connection piece and has one or more lateral openings in the upper part, a container that contains suspended chromatography material and is connected via a line to one or more of the lateral openings, and a container that contains packing medium and is connected via a line to one or more of the lateral openings and/or is connected via a line to the plunger, is suitable for packing a chromatography column. A method for producing chromatography packings with the aid of the device is described.

Abstract: A process for the purification of insulins and insulin derivatives by chromatography in aqueous, buffered solvents which contain water-miscible organic solvents, on lipophilically modified silica gel, is described, wherein the aqueous, buffered solvents contain zwitterions, or the pH of the solvent mixture is in the vicinity of the isoelectric point of the insulin or insulin derivative to be purified and zwitterions are present.

Abstract: A method and circuit for identifying hidden faults in the internal circuit parts of integrated CML-logic-circuits include reducing the voltage difference between the high and low binary signals (logic swing) during testing so that the noise immunity is diminished. The logic swing is reduced by varying reference voltages for constant current sources and differential amplifiers through the use of an integrated control circuit connected to influence reference voltage generators. The control circuit is activated by reducing the supply voltage in a first embodiment or, in a second embodiment, by an external control signal.

Abstract: In order to enable the control of plurality of receivers in CML technology comprising two or three levels of series gating by way of a transmitter whose maximum fanout is smaller than the total number of receivers, the emitter followers provided for level shifting of the control signal for a differential amplifier of the second or third series-gated switch level in each receiver are omitted and are replaced by a common emitter follower having increased performance capability for a respective group of n2 receivers. The invention finds application in 2-bit multiplexers and register stages.