Abstract: The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.

Abstract: The invention relates to a process for the preparation of bone cements comprising active compound and to bone replacement materials or implantable drug depots produced therefrom. The bone cement is composed of a solid component and a liquid component. The liquid component is dissolved in an organic solvent whose proportion does not exceed 50% by weight based on the liquid component, and this solution is mixed with the solid component.

Abstract: The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity.

Abstract: The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.

Abstract: The present invention relates to porous implant materials which are loaded with an excipient/active compound combination, the excipient components used being oligomeric esters of polyhydric alcohols and .alpha.-hydroxy acids.

Abstract: A process and device for producing sterile-packed bone cement, wherein the powder component is gas-sterilized in containers that are used for packing.

Abstract: The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity. The invention also relates to a method of treating wounds, burns, skin ulcers, diabetic gangrene, mucosal ulcers and lesions, skin donation and transplantation sites, or surgical wounds by administering a peptide having FGF activity with an amount of cationic polyelectrolyte which is effective to decrease non-specific binding of the peptide having FGF activity.

Abstract: The invention relates to a process for the preparation of bone cements comprising active compounds and bone replacement materials or implantable drug depots produced therefrom. The bone cement is composed of a solid component and a liquid component. The active compound is dissolved in an organic solvent, the content of which does not exceed 50% by weight, based on the liquid component, and this solution is mixed with the liquid component or with the solid component.

Abstract: The invention relates to a process for the production of spongiosa bone ceramic shaped articles with geometrically irregular shapes and rounded angles and edges, which have no mechanically unstable or inhomogeneous regions. The shaped articles are obtained by treating spongiosa bone ceramic pieces in a ball mill.

Abstract: A solvent for the salt of gentamicin with 3-p-methoxybenzylidene-6-hydroxy-4 '-methoxyflavanone-6-phosphate which is a mixture of from 6 to 9.75 parts by volume of tetrahydrofuran and from 4 to 0.25 parts by volume of water. In these solvents the active compound is soluble up to about 60% by weight. Such a solution is particularly suitable for loading pharmaceutical carriers with this active compound.

Abstract: A process for the preparation of porous bone replacement materials which have a partly or completely interconnecting pore system with a volume content of 5 to 60%. The bone replacement material is prepared from a mixture of a solid component, a liquid component based on acrylate/methacrylate and coarse-particled granules of a biocompatible material with an average particle diameter of 0.5 to 10 mm.

Abstract: The invention relates to the use of clindamycin palmitate for the production of pharmaceutical administration forms having a protracted release of the antibiotic active compound clindamycin, and corresponding administration forms which are preferably used in the form of shaped implants.

Abstract: A femoral prosthesis for implantation by cementation, has the stem with a longitudinal borehole extending proximally to distally for the transprosthetic application of the bone cement. The prosthesis stem is surrounded by an elastic sheath of a biocompatible polymeric material in such a way that, on application of the cement, the sheath is filled advancing distally to proximally and, when the space between stem and bone bed is completely filled, pressed flush against the bone bed.

Abstract: A device for mixing and discharging bone cement has a mixing cylinder which consists of two cylinder parts and in which an openworked mixing plunger can be moved axially. The lower cylinder part is sealed off by a discharging plunger. A separating plunger is arranged axially displaceably in the mixing cylinder between the mixing plunger and the discharging plunger, which separating plunger seals off the one cylinder part before the two cylinder parts are connected. The separating plunger has through-flow channels through which a liquid monomer can flow from the lower cylinder part to a pulverulent polymer in the upper cylinder part at the start of the mixing procedure.