Patents by Inventor Bertrand Goument
Bertrand Goument has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9809553Abstract: A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.Type: GrantFiled: February 20, 2015Date of Patent: November 7, 2017Assignee: LES LABORATOIRES SERVIERInventors: Stéfano Chimenti, Christine Courchay, Aimee Dessinges, Françoise Gellibert, Bertrand Goument, Marc Konnert, Jean-Louis Peglion, Christophe Poitevin, Jean-Paul Vilaine, Nicole Villeneuve
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Publication number: 20170137385Abstract: A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.Type: ApplicationFiled: February 20, 2015Publication date: May 18, 2017Inventors: Stéfano CHIMENTI, Christine COURCHAY, Aimee DESSINGES, Françoise GELLIBERT, Bertrand GOUMENT, Marc KONNERT, Jean-Louis PEGLION, Christophe POITEVIN, Jean-Paul VILAINE, Nicole VILLENEUVE
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Patent number: 8076325Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, —OSO2R10, —OCOR10 or optionally substituted alkoxy group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group —O—(CH2)q—O—, —O—CH?CH—O— or —O—CH?CH—, R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group —O—(CH2)q—O—, R10 represents a group selected from linear or branched C1-C6alkoxy, NR11R?11 and optionally substituted alkyl, R11 and R?11 each represent a hydrogen atom or an alkyl group, or R11 and R?11 together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle, X represents O, NH or CH2, m and p each represent 0 or 1, n and q each represent 1 or 2, in racemic form or in the form of optical isomers, and also addition salts thereType: GrantFiled: September 9, 2008Date of Patent: December 13, 2011Assignee: Les Laboratoires ServierInventors: Jean-Louis Peglion, Bertrand Goument, Aimee Dessinges, Pascal Caignard, Jean-Paul Vilaine, Catherine Thollon, Nicole Villeneuve, Stefano Chimenti
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Patent number: 7612061Abstract: A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.Type: GrantFiled: November 10, 2008Date of Patent: November 3, 2009Assignee: Les Laboratoires ServierInventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Clotilde Mannoury La Cour
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Publication number: 20090076030Abstract: A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.Type: ApplicationFiled: November 10, 2008Publication date: March 19, 2009Applicant: LES LABORATOIRES SERVIERInventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Clotilde Mannoury La Cour
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Publication number: 20090075982Abstract: A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.Type: ApplicationFiled: November 12, 2008Publication date: March 19, 2009Applicant: LES LABORATOIRES SERVIERInventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Clotilde Mannoury La Cour
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Publication number: 20090069296Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, —OSO2R10, —OCOR10 or optionally substituted alkoxy group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group —O—(CH2)q—O—, —O—CH?CH—O— or —O—CH?CH—, R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group —O—(CH2)q—O—-, R10 represents a group selected from linear or branched C1-C6alkoxy, NR11R?11 and optionally substituted alkyl, R11 and R?11 each represent a hydrogen atom or an alkyl group, or R11 and R?1 together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle, X represents O, NH or CH2, m and p each represent 0 or 1, n and q each represent 1 or 2, in racemic form or in the form of optical isomers,and also addition salts thereoType: ApplicationFiled: September 9, 2008Publication date: March 12, 2009Applicant: LES LABORATOIRES SERVIERInventors: Jean-Louis Peglion, Bertrand Goument, Aimee Dessinges, Pascal Caignard, Jean-Paul Vilaine, Catherine Thollon, Nicole Villeneuve, Stefano Chimenti
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Patent number: 7465733Abstract: A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.Type: GrantFiled: March 31, 2006Date of Patent: December 16, 2008Assignee: Les Laboratoires ServierInventors: Jean-Louis Peglion, Aimée Dessinges, Bertrand Goument, Mark Millan, Clotilde Mannoury La Cour
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Publication number: 20060229318Abstract: A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.Type: ApplicationFiled: March 31, 2006Publication date: October 12, 2006Inventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Clotilde La Cour
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Patent number: 6743818Abstract: A compound selected from those of formula (I): wherein: n represents integer from 0 to 6, R1 represents a group selected from hydrogen, hydroxy, cyano, alkoxy, alkoxycarbonyl, carboxy, optionally substituted aminocarbonyl, and NR4R5 wherein R4, and R5 are as defined in the description, R2 represents a group selected from hydrogen, alkyl, hydroxymethyl, and —U—V—W wherein T, U, V, and W are as defined in the description, and R3 represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl, and, heteroaryl, its isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful in the treatment of CNS disorders.Type: GrantFiled: July 12, 2002Date of Patent: June 1, 2004Assignee: Les Laboratoires ServierInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Françoise Lejeune, Didier Cussac
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Publication number: 20030032812Abstract: A compound selected from those of formula (I): 1Type: ApplicationFiled: July 12, 2002Publication date: February 13, 2003Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Francoise Lejeune, Didier Cussac
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Patent number: 6452015Abstract: A compound selected from those of formula (I): wherein: n represents integer from 0 to 6, R1 represents a group selected from hydrogen, hydroxy, cyano, alkoxy, alkoxycarbonyl, carboxy, optionally substituted aminocarbonyl, and NR4R5 wherein R4, and R5 are as defined in the description, R2 represents a group selected from hydrogen, alkyl, hydroxymethyl, and -U-V-W wherein T, U, V, and W are as defined in the description, and R3 represents a group selected from hydrogen, linear or branched (C1-C6)alkyl, aryl, and, heteroaryl, its isomers, and also addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful in the treatment of CNS disorders.Type: GrantFiled: April 12, 2001Date of Patent: September 17, 2002Assignee: Les Laboratoires ServierInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Françoise Lejeune, Didier Cussac
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Patent number: 6420413Abstract: A compound selected from those of formula (I): wherein: denotes single bond or double bond, n is integer from 1 to 6 inclusive, R1, and R2 represent a group selected from hydrogen, linear or branched (C1-C6)-alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, X represents a group selected from —CH═CH—, oxygen, S(O)m wherein m is integer from 0 to 2 inclusive, and NR3 wherein R3 represents a group as defined in the description, Y represents CH or CH2 depending on whether denotes single bond or double bond, or may have the additional meaning of oxygen when X represents oxygen, T represents monocyclic or polycyclic (C3-C10)cycloalkyl optionally containing within the ring system oxygen, selenium, S(O)p, NR3, or SiR4R5 wherein p, R3, R4, and R5 are as defined in the description, its isomers and addition salts thereof with a pharmaceutically-accepType: GrantFiled: April 12, 2001Date of Patent: July 16, 2002Assignee: Les Laboratories ServierInventors: Jean-Louis Peglion, Aimée Dessinges, Bertrand Goument, Mark Millan, Françoise Lejeune, Mauricette Brocco
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Publication number: 20020019380Abstract: A compound selected from those of formula (I): 1Type: ApplicationFiled: April 12, 2001Publication date: February 14, 2002Inventors: Jean-Louis Peglion, Aimee Dessinges, Bertrand Goument, Mark Millan, Francoise Lejeune, Mauricette Brocco
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Publication number: 20010044426Abstract: A compound selected from those of formula (I): 1Type: ApplicationFiled: April 12, 2001Publication date: November 22, 2001Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Francoise Lejeune, Didier Cussac
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Patent number: 6153640Abstract: A compound of formula (I): ##STR1## wherein: R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent a group as defined in the description,R.sub.4 represents hydrogen, alky, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl,R.sub.5 represents aryl, or heteroaryl, each optionally substituted,n is an integer from 1 to 3 inclusive,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are usefull in the treatment of disease like depression, panic attacks, obsessive-compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.Type: GrantFiled: March 23, 2000Date of Patent: November 28, 2000Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Aimee Dessinges, Mark Millan, Jean-Michel Rivet, Anne Dekeyne
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Patent number: 6153625Abstract: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, trihaloalkyl, or any pair may form a heterocycle,R.sub.5 represents hydrogen, alkyl, or arylalkyl,R.sub.6 represents hydrogen, halogen, alkyl, hydroxy, alkoxy, or trihaloalkyl,A, together with the carbons of the phenyl, represents a heterocycle,their isomers and addition pharmaceutically-acceptable acid or base salts thereof, and medicinal products containing the same which are useful in the treatment of pathologies in which 5HT.sub.1B receptors are involved.Type: GrantFiled: August 13, 1999Date of Patent: November 28, 2000Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Adrian Newman-Tancredi
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Patent number: 6060487Abstract: A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.Type: GrantFiled: March 22, 1999Date of Patent: May 9, 2000Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Adrian Newman-Tancredi, Anne Dekeyne
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Patent number: 5968954Abstract: New 2-aminoindan compounds of formula: ##STR1## wherein: n, Ar, R, E, X.sub.1, X.sub.2, X.sub.3, and X.sub.4 are as defined in the description, in the form of a racemic mixture and in the form of optical isomers, and physiologically-tolerable acid addition salts thereof. The products of the invention are useful as medicaments and exhibit selective binding affinity for the 5HT.sub.1B receptors.Type: GrantFiled: February 26, 1998Date of Patent: October 19, 1999Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Alain Gobert
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Patent number: 5965575Abstract: New N-arylpiperidine compounds of formula: ##STR1## wherein: A, m, R, E, n and Ar are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful in the treatment of disorders involving the serotininergic system.Type: GrantFiled: March 27, 1998Date of Patent: October 12, 1999Assignee: Adir Et CompagnieInventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Alain Gobert, Valerie Audinot