Patents by Inventor Bertrand M. C. Plouvier

Bertrand M. C. Plouvier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9586899
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 7, 2017
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20160008322
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 14, 2016
    Inventors: Gregory N. Beatch, Bertrand M.C. Plouvier, Tao Sheng, Michael J.A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zoloty
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20150336887
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: August 4, 2015
    Publication date: November 26, 2015
    Inventors: Bertrand M.C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 9115081
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: August 25, 2015
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Crystalline form of pyrimido[6,1-A] isoquinolin-4-one compound
    Patent number: 9062047
    Abstract: The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: June 23, 2015
    Assignee: Verona Pharma plc
    Inventors: Michael J. A. Walker, Bertrand M. C. Plouvier, Julian S. Northen, Philippe Fernandes
  • ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20140314685
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 23, 2014
    Applicant: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M.C. Plouvier, Tao Sheng, Michael J.A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
  • Synthetic process for aminocyclohexyl ether compounds
    Patent number: 8692002
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: April 8, 2014
    Assignee: Cardiome Pharma Corp.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • Synthetic processes for the preparation of aminocyclohexyl ether compounds
    Patent number: 8618311
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: December 31, 2013
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
  • CRYSTALLINE FORM OF PYRIMIDIO[6,1-A] ISOQUINOLIN-4-ONE COMPOUND
    Publication number: 20130225616
    Abstract: The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.
    Type: Application
    Filed: August 9, 2011
    Publication date: August 29, 2013
    Applicant: VERONA PHARMA PLC
    Inventors: Michael J.A. Walker, Bertrand M.C. Plouvier, Julian S. Northen, Philippe Fernandes
  • SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20130102791
    Abstract: Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 25, 2013
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Bertrand M. C. Plouvier, Doug Ta Hung Chou, Grace Jung, Lewis Siu Leung Choi, Tao Sheng, Anthony G. M. Barrett, Marco S. Passafaro, Martin Kurz, Daniel Moeckli, Pirmin Ulmann, Alfred Hedinger
  • SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20130090483
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 11, 2013
    Applicant: Cardiome Pharma Corp.
    Inventors: Grace JUNG, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
  • Synthetic processes for the preparation of aminocyclohexyl ether compounds
    Patent number: 8344162
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: January 1, 2013
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
  • SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20120271057
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Application
    Filed: November 16, 2011
    Publication date: October 25, 2012
    Applicant: Cardiome Pharma Corp.
    Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M.C. Plouvier
  • Aminocyclohexyl ether compounds and uses thereof
    Patent number: 8163938
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 24, 2012
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
  • SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS
    Publication number: 20120065408
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Application
    Filed: November 16, 2011
    Publication date: March 15, 2012
    Applicant: Cardiome Pharma Corp.
    Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M.C. Plouvier
  • Synthetic processes for the preparation of aminocyclohexyl ether compounds
    Patent number: 8080673
    Abstract: This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R3, R4 and R5 are defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: December 20, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Grace Jung, James Gee Ken Yee, Doug Ta Hung Chou, Bertrand M. C. Plouvier
  • PRODRUGS OF ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF
    Publication number: 20110306649
    Abstract: Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 15, 2011
    Applicant: Cardiome Pharma Corp.
    Inventors: Doug Ta Hung Chou, Adewale Eniade, Bertrand M. C. Plouvier
  • Merged ion channel modulating compounds and uses thereof
    Patent number: 8058304
    Abstract: Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical compositions containing such merged compounds.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: November 15, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Lewis S. L. Choi, Doug Ta Hung Chou, Grace Jung, Bertrand M. C. Plouvier
  • Deuterated aminocyclohexyl ether compounds and processes for preparing same
    Patent number: 8022098
    Abstract: This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: September 20, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Doug Ta Hung Chou, Bertrand M. C. Plouvier, Peter Pang, James Gee Ken Yee, Jeffery Jerome Wheeler, Aregahegn S. Yifru, Allen W. Davidoff
  • Ion channel modulating compounds and uses thereof
    Patent number: 8008342
    Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: August 30, 2011
    Assignee: Cardiome Pharma Corp.
    Inventors: Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander R. Zolotoy