Abstract: The invention is an easy to fold sanitary toilet seat cover for preventing direct contact between an individual's skin and the top and the side surfaces of a toilet seat. When unfolded, the toilet seat cover is sufficiently large to not only cover the entire elongated toilet seat, but also cover the sides of the seat. The disposable toilet seat cover comprises a polygonal annulus that is comprised of a quilted multilayer sheet having a water impervious layer and an absorbent layer, a wipe that is a detachable inner oval section that provides an opening to the toilet, and an adhesive fastening means for temporarily securing the polygonal annulus toilet seat. The water impervious layer comprises a coated layer and/or a filmic layer. The wipe detaches from an inner ovalled edge of the annulus, and is functional as a sanitary wipe or towel.