Patents by Inventor Beth P. Goldstein

Beth P. Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020006406
    Abstract: Lysostaphin is demonstrated to be a powerful anti-staphylococcal agent suitable for parenteral administration to mammals including humans. Low dosages, on the order of 0.5 - 45 mg/kg/day are sufficient to eradicate most staphylococcal infections. Lysostaphin is also effective against bacteria of this type which have developed resistance to conventional antibiotics such as penicillins and vancomycin. Lysostaphin analogues, such as variants and related enzymes, show similar activity.
    Type: Application
    Filed: July 21, 1998
    Publication date: January 17, 2002
    Inventors: BETH P GOLDSTEIN, MICHAEL W CLIMO, RICHARD P NOVICK, GORDON L ARCHER
  • Patent number: 6028051
    Abstract: Lysostaphin is an effective antibiotic in the treatment of staphylococcal infection. Large doses of lysostaphin or lysostaphin analogues are effective in short course, or even one dose administrations, in treating and eradicating staphylococcal infections, including those resistant to conventional antibiotics.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: February 22, 2000
    Assignee: Ambi Inc.
    Inventors: Michael W. Climo, Gordon L. Archer, Beth P. Goldstein
  • Patent number: 5985823
    Abstract: The invention is directed to methods of treating diseases brought on by infection of the colon by C. difficile and also by colonization of vancomycin-resistant enterococci; the methods employ nisin and other lanthionine-containing bacteriocins (lanthocins) as active agents.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: November 16, 1999
    Assignee: Ambi Inc.
    Inventor: Beth P. Goldstein
  • Patent number: 5910479
    Abstract: The invention concerns methods for killing antibiotic-resistant pathogenic bacteria which cause disease in humans and animals. In particular, the methods are directed to the killing of antibiotic-resistant or multi-drug resistant Streptococcus pneumoniae bacterial strains. The methods employ a lanthocin such as nisin or a variant thereof as bactericidal agent.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 8, 1999
    Assignee: AMBI Inc.
    Inventor: Beth P. Goldstein
  • Patent number: 5866539
    Abstract: The invention concerns methods for killing antibiotic-resistant pathogenic bacteria responsible for disease in humans and animals. The methods employ a lanthocin such as nisin as bactericidal agent.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: February 2, 1999
    Assignee: AMBI Inc.
    Inventors: Peter Blackburn, Beth P. Goldstein
  • Patent number: 5804549
    Abstract: Disclosed are compositions of nisin and GML as active ingredients for the killing of Helicobacter, as well as methods for eradicating Helicobacter colonization and treatment of Helicobacter infection which employ the GML/nisin compositions.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: September 8, 1998
    Assignee: AMBI Inc.
    Inventors: Peter Blackburn, Beth P. Goldstein, Debra J. Cook
  • Patent number: 5752941
    Abstract: The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: May 19, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Gabriella Romano', Beth P. Goldstein, Rosamund Jean Williams, Maurizio Denaro
  • Patent number: 5322777
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: June 21, 1994
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Patent number: 5202241
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 13, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Patent number: 5141953
    Abstract: Use of the antibiotic purpuromycin for the topical treatment of infectious vaginitis and topical dosage forms containing said product. The antibiotic purpuromycin is simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: August 25, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Francesco Parenti, Beth P. Goldstein, Luigi Simioni
  • Patent number: 5118705
    Abstract: Water soluble salts of purpuromycin, their use for the topical treatment of infectious vaginitis and topical dosage forms containing said products. Oral and parenteral formulations for administration of the water soluble purpuromycin salts. The water soluble salts of purpuromycin are simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: June 2, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Aldo Trani, Sergio Bellini, Beth P. Goldstein, Luigi Simioni
  • Patent number: 4935238
    Abstract: The present invention concerns a new antibiotic substance arbitrarily denominated antibiotic A 40926 complex and its factors antibiotic A 40926 factor A, antibiotic A 40926 factor B, antibiotic A 40926 factor B.sub.0, antibiotic A 40926 factor PA and antibiotic A 40926 factor PB, a process for producing them by culturing the new strain Actinomadura sp. ATCC 39727 or an A 40926 producing variant or mutant thereof and the use of these new antibiotic substances in the treatment of infectious diseases involving microorganisms susceptible to them. The antibiotic substances of the invention are glycopeptidic substances belonging to the vancomycin class of antibiotics which have binding capacity to Acyl-D-Alanyl-D-Alanine.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: June 19, 1990
    Assignee: Gruppo Lepetit, S.p.A.
    Inventors: Enrico Selva, Grazia Beretta, Luciano Gastaldo, Angelo Borghi, Beth P. Goldstein, Giovanni Cassani, Vittorio Arioli, Francesco Parenti
  • Patent number: 4782042
    Abstract: The present invention concerns a new antibiotic substance denominated antibiotic A 40926 mannosyl aglycon and the addition salts thereof, a process for preparing it from antibiotic A 40926 complex or a factor thereof, and its use in the treatment of infectious disease involving microorganisms susceptible to it.
    Type: Grant
    Filed: December 23, 1986
    Date of Patent: November 1, 1988
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Beth P. Goldstein, Pietro Ferrari, Giovanni Cassani, Francesco Parenti