Patents by Inventor Bettina Rosner

Bettina Rosner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8017355
    Abstract: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention provides bacterial cells that have been genetically altered to inhibit the metabolism or degradation of mannitol, glucitol, or arabitol, or derivatives or analogues thereof. The present invention utilizes mannitol, arabitol, glucitol, or glycerol to induce expression of a target polypeptide from an inducible promoter, allowing for the use of an inexpensive and stable carbon source inducer in the fermentation processes for the production of recombinant peptides.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: September 13, 2011
    Assignee: Pfenex, Inc.
    Inventors: J. Carrie Schneider, Bettina Rosner
  • Publication number: 20090162899
    Abstract: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention provides bacterial cells that have been genetically altered to inhibit the metabolism or degradation of mannitol, glucitol, or arabitol, or derivatives or analogues thereof. The present invention utilizes mannitol, arabitol, glucitol, or glycerol to induce expression of a target polypeptide from an inducible promoter, allowing for the use of an inexpensive and stable carbon source inducer in the fermentation processes for the production of recombinant peptides.
    Type: Application
    Filed: December 9, 2008
    Publication date: June 25, 2009
    Applicant: Dow Global Technologies Inc.
    Inventors: J. Carrie Schneider, Bettina Rosner
  • Patent number: 7476532
    Abstract: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention provides bacterial cells that have been genetically altered to inhibit the metabolism or degradation of mannitol, glucitol, or arabitol, or derivatives or analogues thereof. The present invention utilizes mannitol, arabitol, glucitol, or glycerol to induce expression of a target polypeptide from an inducible promoter, allowing for the use of an inexpensive and stable carbon source inducer in the fermentation processes for the production of recombinant peptides.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: January 13, 2009
    Assignee: Dow Global Technologies Inc.
    Inventors: J. Carrie Schneider, Bettina Rosner
  • Publication number: 20080004542
    Abstract: A medical apparatus (10) for detecting a predetermined component of breath and producing a breath-component signal over a measurement time. Such breath-component signal may be related to a fat metabolism indicator.
    Type: Application
    Filed: July 23, 2007
    Publication date: January 3, 2008
    Inventors: Jeffrey Allen, Paul Cranley, Kristine Danowski, James McIntyre, Reed Shick, Bettina Rosner, Larry Sun
  • Publication number: 20060289640
    Abstract: A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that t
    Type: Application
    Filed: May 18, 2006
    Publication date: December 28, 2006
    Inventors: Peter Mercure, Kristine Danowski, Larry Sun, Robert Haley, Douglas White, Michelle Pressler, Susan Babinec, Flor Castillo, Jahne Simon, Paul Cranley, Malcolm Warren, Diedre Strand, Bettina Rosner, Robert Fletcher, Christopher Jones, Thomas Kalantar, Mark Bernius, W. McDougall, Mark Felix
  • Publication number: 20060292671
    Abstract: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention provides bacterial cells that have been genetically altered to inhibit the metabolism or degradation of mannitol, glucitol, or arabitol, or derivatives or analogues thereof. The present invention utilizes mannitol, arabitol, glucitol, or glycerol to induce expression of a target polypeptide from an inducible promoter, allowing for the use of an inexpensive and stable carbon source inducer in the fermentation processes for the production of recombinant peptides.
    Type: Application
    Filed: June 6, 2006
    Publication date: December 28, 2006
    Inventors: J. Schneider, Bettina Rosner
  • Publication number: 20050084921
    Abstract: Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.
    Type: Application
    Filed: May 5, 2004
    Publication date: April 21, 2005
    Inventors: Paul Cranley, Jeffrey Allen, Kristine Danowski, James McIntyre, Theodore Miller Jr, Bettina Rosner, Alan Strickland, Venkiteswaran Subramanian, Larry Sun