Patents by Inventor Bevin Engelward
Bevin Engelward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9589173Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: GrantFiled: May 5, 2014Date of Patent: March 7, 2017Assignee: Massachusetts Institute of TechnologyInventors: Peter T. C. So, Bevin Engelward, Timothy Ragan, Karsten Bahlman, Ki-Hean Kim, Lily Hsu Laiho, Hayden Huang
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Publication number: 20140355862Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: May 5, 2014Publication date: December 4, 2014Inventors: Peter T.C. So, Bevin Engelward, Timothy Ragan, Karsten Bahlman, Ki-Hean Kim, Lily Hsu Laiho, Hayden Huang
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Patent number: 8718351Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: GrantFiled: December 26, 2012Date of Patent: May 6, 2014Assignee: Massachusetts Institute of TechnologyInventors: Peter T. c. So, Bevin Engelward, Timothy Ragan, Karsten Bahlman, Ki-Hean Kim, Lily Hsu Laiho, Hayden Huang
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Publication number: 20130142413Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: December 26, 2012Publication date: June 6, 2013Inventors: Peter T.c. So, Bevin Engelward, Timothy Ragan, Karsten Bahlman, Ki-Hean Kim, Lily Hsu Laiho, Hayden Huang
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Patent number: 8351675Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: GrantFiled: April 9, 2010Date of Patent: January 8, 2013Assignee: Massachusetts Institute of TechnologyInventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Hean Kim, Lily Hsu-Laiho, Hayden Huang
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Publication number: 20100259605Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: April 9, 2010Publication date: October 14, 2010Inventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Hean Kim, Lily Hsu Laiho, Hayden Huang
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Patent number: 7724937Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: GrantFiled: May 12, 2008Date of Patent: May 25, 2010Assignee: Massachusetts Institute of TechnologyInventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Hean Kim, Lily Hsu Laiho, Hayden Huang
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Publication number: 20090072171Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: May 12, 2008Publication date: March 19, 2009Applicant: Massachusetts Institute of TechnologyInventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Hean Kim, Lily Hsu Laiho, Hayden Huang
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Patent number: 7372985Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: GrantFiled: August 15, 2003Date of Patent: May 13, 2008Assignee: Massachusetts Institute of TechnologyInventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Hean Kim, Lily Hsu, Hayden Huang
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Publication number: 20060056589Abstract: One aspect of the present invention relates to a method for determining an adaptive response of a tumor during radiation therapy. A second aspect of the present invention relates to a method for determining a substantially optimal dose of radiation therapy based on a cells ability to undergo an adaptive response. Another aspect of the present invention relates to a method for identifying small molecule compounds that are effective chemotherapeutic agents for use during and after radiation therapy.Type: ApplicationFiled: August 23, 2005Publication date: March 16, 2006Applicant: Massachusetts Institute of TechnologyInventor: Bevin Engelward
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Publication number: 20050036667Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: August 15, 2003Publication date: February 17, 2005Applicant: Massachusetts Institute of TechnologyInventors: Peter So, Bevin Engelward, Timothy Ragan, Karsten Bahlmann, Ki Kim, Lily Hsu, Hayden Huang