Patents by Inventor Bhalchandra Lele
Bhalchandra Lele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9777069Abstract: Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP.Type: GrantFiled: April 4, 2014Date of Patent: October 3, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Bhalchandra Lele
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Publication number: 20160376464Abstract: A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.Type: ApplicationFiled: September 8, 2016Publication date: December 29, 2016Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Bhalchandra Lele, Pratap Singh, Raphael Bartz, Jason A. Kellogg
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Publication number: 20140221626Abstract: Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP.Type: ApplicationFiled: April 4, 2014Publication date: August 7, 2014Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventor: Bhalchandra LELE
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Patent number: 8771964Abstract: Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly (amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP.Type: GrantFiled: February 2, 2012Date of Patent: July 8, 2014Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Bhalchandra Lele
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Publication number: 20130345357Abstract: A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.Type: ApplicationFiled: August 22, 2013Publication date: December 26, 2013Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Bhalchandra Lele, Pratap Singh, Raphael Bartz, Jason A. Kellogg
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Patent number: 8546148Abstract: A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.Type: GrantFiled: April 9, 2012Date of Patent: October 1, 2013Assignee: Siemens Healthcare Diagnostics IncInventors: Bhalchandra Lele, Pratap Singh, Raphael Bartz, Jason A. Kellogg
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Publication number: 20130203076Abstract: Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly(amino acid) label moieties, poly(amino acid) immunogenic carriers, non-poly(amino acid) immunogenic carriers, non-label poly(amino acid) moieties, and non-immunogenic carrier poly(amino acid) moieties linked to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine at the 3-position of one of the phenyl rings. Antibodies produced from immunogenic EDDP conjugates and labeled EDDP conjugates are employed in assays for determining the presence and/or amount of EDDP in samples suspected of containing EDDP.Type: ApplicationFiled: February 2, 2012Publication date: August 8, 2013Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventor: Bhalchandra Lele
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Patent number: 8394647Abstract: Methods and reagents are disclosed for reducing an amount of non-covalently bound polysaccharide on a support. The method comprises contacting a support comprising both covalently bound polysaccharide and non-covalently bound polysaccharide with an aqueous solution comprising an amount of a chaotropic agent effective to remove non-covalently bound polysaccharide from the support.Type: GrantFiled: February 17, 2011Date of Patent: March 12, 2013Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Bhalchandra Lele, Pratap Singh, Asoke Chatterjee
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Publication number: 20120214978Abstract: Methods and reagents are disclosed for reducing an amount of non-covalently bound polysaccharide on a support. The method comprises contacting a support comprising both covalently bound polysaccharide and non-covalently bound polysaccharide with an aqueous solution comprising an amount of a chaotropic agent effective to remove non-covalently bound polysaccharide from the support.Type: ApplicationFiled: February 17, 2011Publication date: August 23, 2012Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Bhalchandra Lele, Pratap Singh, Asoke Chatterjee
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Publication number: 20120208297Abstract: A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.Type: ApplicationFiled: April 9, 2012Publication date: August 16, 2012Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Bhalchandra Lele, Pratap Singh, Raphael Bartz, Jason A. Kellogg
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Publication number: 20110306148Abstract: A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.Type: ApplicationFiled: June 14, 2010Publication date: December 15, 2011Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Bhalchandra Lele, Pratap Singh, Raphael Bartz, Jason A. Kellogg
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Publication number: 20070123646Abstract: A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator composition; and mixing the protein-initiator composition with at least one monomer which undergoes controlled radical polymerization in the presence of the protein-initiator composition under conditions suitable to initiate the controlled radical polymerization.Type: ApplicationFiled: September 13, 2006Publication date: May 31, 2007Inventors: Bhalchandra Lele, Alan Russell
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Publication number: 20060116451Abstract: A composition includes at least one antioxidant moiety and at least one UV-absorbing moiety. The antioxidant moiety and the UV-absorbing moiety are maintained in proximity to each other. The UV-absorbing moiety and the antioxidant moiety can, for example, be attached to a common entity. The antioxidant moiety and the UV-absorbing moiety can, for example, be covalently attached within a single molecule. The UV-absorbing moiety can be attached sufficiently closely to the antioxidant moiety to enhance the stability of the antioxidant in an environment in which photooxidation can occur. In one embodiment, the UV-absorbing moiety is attached to the molecule to be juxtapositioned to the antioxidant moiety.Type: ApplicationFiled: November 29, 2005Publication date: June 1, 2006Inventors: Bhalchandra Lele, Alan Russell
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Publication number: 20050130867Abstract: The present invention provides novel thermoprecipitating polymers of formula 1 containing novel enzyme sensitive ligands of the formula 4, processes for the preparation thereof respectively, and to the use thereof for the separation of enzymes. In formula 1 R is hydrogen or methyl, 1 is an integer in the range of from 1 to 10, m and n are either 0 or 1, x and y are integers greater than 1.Type: ApplicationFiled: January 31, 2005Publication date: June 16, 2005Inventors: Alankar Vaidya, Bhalchandra Lele, Mohan Kulkarni, Raghunath Mashelkar