Patents by Inventor Bhami C. Shenoy

Bhami C. Shenoy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20220133865
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: June 17, 2021
    Publication date: May 5, 2022
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20200129599
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: June 19, 2019
    Publication date: April 30, 2020
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • Crystallized oxalate decarboxylase and methods of use
    Patent number: 10369203
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: August 6, 2019
    Assignee: Allena Pharmaceuticals, Inc.
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20180250371
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: October 23, 2017
    Publication date: September 6, 2018
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20180214522
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: October 23, 2017
    Publication date: August 2, 2018
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • Crystallized oxalate decarboxylase and methods of use
    Patent number: 9821041
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: November 21, 2017
    Assignee: Allena Pharmaceuticals, Inc.
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20160051647
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: September 2, 2015
    Publication date: February 25, 2016
    Applicant: AJINOMOTO ALTHEA, INC.
    Inventors: BHAMI C. SHENOY, TERESA G. CACHERO, JOHN SHIN, LEKAI ZHANG, AFTAB RASHID, DANICA GRUJIC, REENA J. PATEL, MARGARET ELLEN MCGRATH
  • Crystallized oxalate decarboxylase and methods of use
    Patent number: 9155785
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: October 13, 2015
    Assignee: AJINOMOTO ALTHEA, INC.
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE
    Publication number: 20150004204
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: May 21, 2014
    Publication date: January 1, 2015
    Inventors: Bhami C. SHENOY, Teresa G. Cachero, John SHIN, Lekai ZHANG, Aftab RASHID, Danica GRUJIC, Reena J. Patel, Margaret Ellen MCGRATH
  • Crystallized oxalate decarboxylase and methods of use
    Patent number: 8741284
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: June 3, 2014
    Assignee: Althea Technologies, Inc.
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • Stabilized Protein Crystals, Formulations Containing Them and Methods of Making Them
    Publication number: 20140086988
    Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein crystals, formulations and compositions comprising them. Provided are methods and compositions for encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery.
    Type: Application
    Filed: September 9, 2013
    Publication date: March 27, 2014
    Applicant: Althea Technologies, Inc.
    Inventors: Alexey L. MARGOLIN, Nazar K. KHALAF, Nancy L. ST. CLAIR, Scott L. RAKESTRAW, Bhami C. SHENOY
  • Stabilized protein crystals, formulations comprising them and methods of making them
    Patent number: 8558048
    Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: October 15, 2013
    Assignee: Althea Technologies, Inc.
    Inventors: Alexey L. Margolin, Nazar K. Khalaf, Nancy L. St. Clair, Scott L. Rakestraw, Bhami C. Shenoy
  • Crystallized Oxalate Decarboxylase and Methods of Use
    Publication number: 20120308545
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Application
    Filed: February 13, 2012
    Publication date: December 6, 2012
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • Crystallized oxalate decarboxylase and methods of use
    Patent number: 8142775
    Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: March 27, 2012
    Assignee: Althea Technologies, Inc.
    Inventors: Bhami C. Shenoy, Teresa G. Cachero, John Shin, Lekai Zhang, Aftab Rashid, Danica Grujic, Reena J. Patel, Margaret Ellen McGrath
  • STABILIZED PROTEIN CRYSTALS, FORMULATIONS COMPRISING THEM AND METHODS OF MAKING THEM
    Publication number: 20100255100
    Abstract: This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition.
    Type: Application
    Filed: October 30, 2009
    Publication date: October 7, 2010
    Applicant: Altus Pharmaceuticals Inc.
    Inventors: Alexey J. Margolin, Nazar K. Khalaf, Nancy L. St. Clair, Scott L. Rakestraw, Bhami C. Shenoy
  • COMPOSITIONS AND METHODS FOR TREATING PANCREATIC INSUFFICIENCY
    Publication number: 20100196344
    Abstract: The present invention relates to compositions for the treatment of conditions, including pancreatic insufficiency. The compositions of the present invention comprise lipase, protease and amylase in a particular ratio that provides beneficial results in patients, such as those afflicted with pancreatic insufficiency. This invention also relates to methods using such compositions for the treatment of pancreatic insufficiency.
    Type: Application
    Filed: April 5, 2010
    Publication date: August 5, 2010
    Applicant: Cystic Fibrosis Foundation Therapeutics, Inc.
    Inventors: Alexey L. Margolin, Bhami C. Shenoy, Frederick T. Murray, Anthony Christopher Lee Stevens
  • Compositions and methods for treating pancreatic insufficiency
    Patent number: 7718169
    Abstract: The present invention relates to compositions for the treatment of conditions, including pancreatic insufficiency. The compositions of the present invention comprise lipase, protease and amylase in a particular ratio that provides beneficial results in patients, such as those afflicted with pancreatic insufficiency. This invention also relates to methods using such compositions for the treatment of pancreatic insufficiency. The compositions specifically comprise crosslinked Burkholderia cepacia lipase crystals, Aspergillus melleus protease crystals and amorphous Aspergillus oryzae amylase in a ratio of about 1:1:0.15 USP units.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: May 18, 2010
    Assignee: Cystic Fibrosis Foundations Therapeutics, Inc.
    Inventors: Alexey L. Margolin, Bhami C. Shenoy, Frederick T. Murray, Anthony Christopher Lee Stevens
  • NON-PANCREATIC PROTEASES FOR CONTROLLING PLASMA CHOLECYSTOKININ (CCK) CONCENTRATION AND FOR TREATING PAIN
    Publication number: 20090081184
    Abstract: This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.
    Type: Application
    Filed: October 24, 2008
    Publication date: March 26, 2009
    Applicant: Altus Pharmaceuticals Inc.
    Inventors: Alexey L. Margolin, Bhami C. Shenoy, Margaret McGrath
  • Method to Reduce Oxalate Concentration by Administration of Oxalate Oxidase Crystals
    Publication number: 20080311101
    Abstract: The invention relates to methods to prevent, treat, or slow the progression of a disorder associated with elevated oxalate concentration, the method comprising administering oxalate oxidase crystals, cross-linked crystals, or compositions containing those crystals to an individual. Oxalate oxidase crystals and compositions for administration to an individual are also provided, including stabilized crystals, such as cross-linked crystals of oxalate oxidase.
    Type: Application
    Filed: June 12, 2006
    Publication date: December 18, 2008
    Inventors: Bhami C. Shenoy, Mark X. Yang, Margaret Ellen McGrath, Alexey L. Margolin
  • Treating abdominal pain due to pancreatitis with seaprose
    Patent number: 7459155
    Abstract: This invention relates to methods for maintaining the basal level or reducing the level of cholecystokinin (CCK) in blood plasma of a mammal. Additionally, the invention provides methods for treating pain in a mammal and more particularly, methods for treating abdominal pain in a mammal. The methods include administering to the mammal a non-pancreatic protease or a composition comprising a non-pancreatic protease. The methods of this invention are particularly useful for treating abdominal pain in a mammal suffering from acute or chronic pancreatitis and related conditions.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: December 2, 2008
    Assignee: Altus Pharmaceuticals Inc.
    Inventors: Alexey L. Margolin, Bhami C. Shenoy, Margaret McGrath