Patents by Inventor Bhausaheb Pandharinath Khadangale

Bhausaheb Pandharinath Khadangale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of cefoxitin
    Patent number: 7662955
    Abstract: A process for the preparation of cefoxitin of formula (I) The process includes treating the compound of formula (II) with a halogenating agent in an organic solvent, followed by treatment with alkali/alkaline earth metal methoxide at a temperature in the range of ?100° C. to 0° C. The product formed is then isolated as an organic amine salt of the formula (III), The salt of formula (III) is treated with a base in the presence of solvent at a temperature in the range of ?75 to 10° C., the product formed is isolated as an organic amine salt of the formula (IV) The compound of formula (IV) is carbamoylated with isocyanate of formula (V) RNCO??(V) in the presence of a solvent at a temperature in the range of ?60° C. to 10° C., and isolating to get cefoxitin of the formula (I).
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: February 16, 2010
    Assignee: Orchid Chemicals and Pharmaceuticals Ltd.
    Inventors: Pandurang Balwant Deshpande, Bhausaheb Pandharinath Khadangale
  • Amorphous hydrate of a cephalosporin antibiotic
    Patent number: 7244842
    Abstract: A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: July 17, 2007
    Assignee: Orchid Chemicals & Pharmaceuticals Ltd.
    Inventors: Pandurang Balwant Desphande, Bhausaheb Pandharinath Khadangale, Chandrasekaran Ramasubbu
  • Process for the preparation of 3-propenyl cephalosporin DMF solvate
    Patent number: 6903211
    Abstract: The present invention relates to an improved process for the preparation of cefprozil DMF solvate of formula (I), which is useful for the preparation of cefprozil, comprising: i) reacting a compound of formula (VIII) with acetaldehyde to produce a compound of formula (IX), ii) deesterifying the carboxy protecting group of the compound of formula (IX) using an acid to yield a compound of formula (X), iii) converting the compound of formula (X) to a compound of formula (XI), iv) neutralizing the compound of formula (XI) followed by enzymatic hydrolysis to produce an APCA of formula (V), v) silylating the APCA using a mixture of trimethylsilylchloride and hexamethyldisilazane to produce silylated APCA of formula (XII), and vi) condensing the silylated APCA with a mixed anhydride to produce the DMF solvate compound of formula (I).
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: June 7, 2005
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Bhausaheb Pandharinath Khadangale, Kumar Gurusamy, Ramesh Athmaram Konda
  • Synthesis of ceftiofur intermediate
    Patent number: 6803461
    Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: October 12, 2004
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Process for the preparation of cefuroxime sodium
    Publication number: 20040092735
    Abstract: The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).
    Type: Application
    Filed: December 5, 2002
    Publication date: May 13, 2004
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Gautam Kumar Das, John Muthiah Raja Jeyakumar
  • Process for the preparation of 3-propenyl cephalosporin DMF solvate
    Publication number: 20040087786
    Abstract: The present invention relates to an improved process for the preparation of 3-propenyl cephalosporin DMF solvate, more particularly, the present invention relates to an improved process for the preparation of cefprozil DMF solvate of the formula (I), which is useful for the preparation of cefprozil of the formula (XIV).
    Type: Application
    Filed: December 10, 2002
    Publication date: May 6, 2004
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Pandurang Balwant Deshpande, Bhausaheb Pandharinath Khadangale, Kumar Gurusamy, Ramesh Athmaram Konda
  • Synthesis of ceftiofur intermediate
    Publication number: 20030135041
    Abstract: The present invention provides an improved process for the preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid represented by formula (I) 1
    Type: Application
    Filed: January 4, 2002
    Publication date: July 17, 2003
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das
  • Synthesis of ceftiofur intermediate
    Publication number: 20030130502
    Abstract: The present invention relates to a process for preparation of 7-amino-3-[2-(furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid (I) by the condensation of 7-aminocephalosporanic acid (II) with furyl-2-carbonylthiol (III) in the presence of borontrifluoride or its complex, in an organic solvent or mixture of solvents at 0-50° C.
    Type: Application
    Filed: August 1, 2002
    Publication date: July 10, 2003
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pramod Narayan Deshpande, Bhausaheb Pandharinath Khadangale, Surulichamy Senthil Kumar, Gautam Kumar Das