Patents by Inventor Bianca Bethan
Bianca Bethan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10436798Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: GrantFiled: July 27, 2012Date of Patent: October 8, 2019Assignees: Metanomics GmbH, Ruprecht-Karls-Universität HeidelbergInventors: Regina Reszka, Jens Fuhrmann, Jürgen Kastler, Bianca Bethan, Martin Kluttig, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Publication number: 20160209433Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject based on a group of biomarkers. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: September 1, 2014Publication date: July 21, 2016Inventors: Henning Witt, Juergen Kastler, Bianca Bethan, Erik Peter, Philipp Schatz, Hans Dirk Duengen, Tobias Daniel Trippel, Elvis Tahirovic, Hugo A. Katus, Norbert Frey, Tanja Weis
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Publication number: 20150241406Abstract: The present invention concerns means and methods for cancer diagnosis and, in particular, diagnosis of prostate cancer. Specifically, it relates to a method for diagnosing whether a subject is at risk for recunent prostate carcinoma after prostatectomy comprising determining the amount of at least one metabolite selected from Table 2 in a test sample of a subject after prostatectomy, and comparing the determined amount to a reference, whereby it is diagnosed whether the subject is at risk for recurrent prostate carcinoma after prostatectomy. Further methods provided in accordance with the present invention relate to differentiating between a malignant prostate carcinoma tissue and a non-malignant tissue and diagnosing metastasizing prostate carcinoma in a subject. Also provided are devices for carrying out the aforementioned methods.Type: ApplicationFiled: October 2, 2013Publication date: August 27, 2015Applicants: Charité Universitätsmedizin Berlin, Metanomics Health GmbHInventors: Regina Reszka, Beate Kamlage, Bianca Bethan, Klaus Jung, Michael Lein, Glen Kristiansen, Carsten Stephan
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Publication number: 20150160238Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject and a method for monitoring progression or regression of heart failure in a subject. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.Type: ApplicationFiled: July 27, 2012Publication date: June 11, 2015Applicants: RUPRECHT-KARLS-UNIVERISTÄT HEIDELBERG, METANOMICS GMBHInventors: Regina Reszka, Jens Fuhrmann, Jürgen Kastler, Bianca Bethan, Martin Kluttig, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
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Patent number: 8216847Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes, comprising determining a metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing the metabolite to a reference to diagnose the, predisposition for diabetes. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising the data collection. The present invention also relates to a system comprising methods or devices for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Additionally, diagnostic methods or devices comprising a metabolite and its use for manufacture of the diagnostic method or device for diagnosing a predisposition for diabetes are provided, along with a method for identifying diabetes-related metabolites.Type: GrantFiled: March 21, 2007Date of Patent: July 10, 2012Assignee: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan C Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Patent number: 8216848Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof, comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing the metabolite to a reference to diagnose diabetes or a predisposition therefor. The present invention further encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising the data collection. The present invention also relates to a system comprising methods or devices for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. The present invention also encompasses diagnostic methods or devices comprising at least one metabolite and use of the metabolite for the manufacture of diagnostic methods and devices for diagnosing diabetes; and a method for identifying diabetes-related metabolites.Type: GrantFiled: March 21, 2007Date of Patent: July 10, 2012Assignee: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan C Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Publication number: 20120122243Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium.Type: ApplicationFiled: June 2, 2010Publication date: May 17, 2012Applicants: CHARITE UNIVERSITATSMEDIZIN BERLIN, METANOMICS HEALTH GMBHInventors: Beate Kamlage, Bianca Bethan, Regina Reszka, Edgar Leibold, Klaus Jung, Michael Lein, Glen Kristiansen
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Patent number: 7873481Abstract: A method for analyzing a test sample is disclosed, the test sample comprising at least one compound. A test sample comprising at least one compound is provided. Next, the at least one compound in the test sample is determined, thereby generating raw results. The generated raw results are analyzed, wherein the analysis of the test sample is accompanied by an analysis of at least one reference sample. The test sample and the reference sample are analyzed in an identical sequence in each step of the method. A system for carrying out the method is also disclosed.Type: GrantFiled: July 25, 2006Date of Patent: January 18, 2011Assignee: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Bianca Bethan, Michael Manfred Herold, Beate Kamlage, Oliver Schmitz, Jan C. Wiemer, Alexandre Prokoudine, Bennard Van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Thomas Ehrhardt, Gerhard Krennrich
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Publication number: 20100236321Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes.Type: ApplicationFiled: March 21, 2007Publication date: September 23, 2010Applicant: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Publication number: 20100163720Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes.Type: ApplicationFiled: March 21, 2007Publication date: July 1, 2010Applicant: Metanomics GmbHInventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
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Publication number: 20080234945Abstract: The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method.Type: ApplicationFiled: July 25, 2006Publication date: September 25, 2008Applicant: METANOMICS GMBHInventors: Tilmann B. Walk, Ralf Looser, Bianca Bethan, Michael Manfred Herold, Beate Kamlage, Oliver Schmitz, Jan C Wiemer, Alexandre Prokoudine, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunba, Thomas Ehrhardt, Gerhard Krennrich