Abstract: Embodiments of the present disclosure relate to multimedia processing method, apparatus, device and medium, wherein the method includes: presenting a first multimedia interface comprising first content; receiving an interface switching request of a user in the first multimedia interface; and switching from the first multimedia interface currently presented to a second multimedia interface, and presenting second content in the second multimedia interface, wherein the first content comprises the second content and other content associated with the second content, and the second content comprises a target audio and a target subtitle corresponding to the target audio.

Abstract: A unified platform including an exosome-based method has been developed that uses only immunogenic epitopes for nanovaccine production. By eliminating these nonessential sequences from the full-length antigen, this new type of nanovaccine is safer as compared to those of existing vaccines. In addition, careful selection of targeting epitopes and incorporation of multiple epitope repeats into nanovaccine will make it more potent and precise than the traditional vaccines.

Abstract: Disclosed are an oxa-azasipro derivative, a preparation method therefor and a pharmaceutical use thereof. In particular, disclosed are an oxa-azasipro derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use thereof as a therapeutic agent, especially the use thereof as a PI3K? inhibitor and the use thereof in the preparation of a drug for treating diseases or conditions improved by means of inhibiting PI3K?.

Abstract: Provided are a flexible insulated air duct and a modular flexible insulated air-duct system; the flexible insulated air duct includes an air-duct main body (1); the air-duct main body (1) includes an inner air-duct layer (5) and a heat-insulating layer (4) integrally formed on the inner air-duct layer (5); the inner air-duct layer (5) is arranged inside the heat-insulating layer (4), and the heat-insulating layer (4) is a rubber/plastic material. The modular flexible insulated air-duct system made by assembling a main air duct (7), a branched air duct (8), and a connecting air duct (9) may be rapidly connected on-site using a zip fastener to form an air-duct system having any configuration.

Abstract: Aerosol formulations of granisetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Aerosol formulations of ondansetron useful for pulmonary delivery are provided. The formulations are useful in the reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONY) using the inhalation formulations.

Abstract: The present invention discloses a multilayer composite rubber-plastic foam insulation material and a preparation method thereof. The composite rubber-plastic foam insulation material includes a two-layer structure; the two-layer structure includes an insulation layer and a first functional layer; the insulation layer and the first functional layer are both made of a rubber-plastic foam material; the first functional layer and the insulation layer are integrally molded by blending extrusion and vulcanization foaming, and the first functional layer and the insulation layer form an integral structure. The multilayer composite rubber-plastic foam insulation material provided by the present invention adopts a vulcanization foaming integral molding process, and not only ensures the thermal insulation property of the insulation layer, but also gives the functional layer corresponding functions by selecting different functional polymers, thereby satisfying a variety of personalized needs in engineering applications.

Abstract: The present disclosure provides for palonosetron formulations, such as aerosol formulations of palonosetron for pulmonary delivery. Also provided are uses of the formulation, such as reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, or surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONV) using the inhalation formulations.

Abstract: Provided are a flexible insulated air duct and a modular flexible insulated air-duct system; the flexible insulated air duct includes an air-duct main body (1); the air-duct main body (1) includes an inner air-duct layer (5) and a heat-insulating layer (4) integrally formed on the inner air-duct layer (5); the inner air-duct layer (5) is arranged inside the heat-insulating layer (4l), and the heat-insulating layer (4) is a rubber/plastic material. The modular flexible insulated air-duct system made by assembling a main air duct (7), a branched air duct (8), and a connecting air duct (9) may be rapidly connected on-site using a zip fastener to form an air-duct system having any configuration.

Abstract: A heteroaryl[4,3-c]pyrimidin-5-amine derivative, a preparation method therefor, and medical uses thereof are provided. Specifically, a heteroaryl[4,3-c]pyrimidin-5-amine derivative of formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and uses thereof as therapeutic agents are provided. In particular, the provided compounds can be used as A2a receptor antagonists and for treatment of conditions or symptoms that are ameliorated by inhibiting the A2a receptor. The various substituent groups in the formula (I) have the meanings as described in the specification.

Abstract: Provided are a flexible insulated air duct and a modular flexible insulated air-duct system; the flexible insulated air duct includes an air-duct main body (1); the air-duct main body (1) includes an inner air-duct layer (5) and a heat-insulating layer (4) integrally formed on the inner air-duct layer (5); the inner air-duct layer (5) is arranged inside the heat-insulating layer (4), and the heat-insulating layer (4) is a rubber/plastic material. The modular flexible insulated air-duct system made by assembling a main air duct (7), a branched air duct (8), and a connecting air duct (9) may be rapidly connected on-site using a zip fastener to form an air-duct system having any configuration.

Abstract: An apparatus is described. The apparatus comprises a downstream wavelength selective switch having an input port, an optical path operable to carry an optical signal, an optical source providing amplified spontaneous emission (ASE) light, an optical switch having a first input coupled to the optical path, a second input coupled to the optical source and receiving the ASE light, and an output coupled to the input port of the downstream wavelength selective switch. The optical switch couples either the first input or the second input to the output. Further included is a photodiode operable to monitor the optical signal, detect an optical loss of signal of the optical signal, and output a switch signal to the optical switch such that the optical switch couples the second input receiving the ASE light to the output whereby the ASE light is directed to the input port of the downstream wavelength selective switch.

Abstract: The present invention discloses a multilayer composite rubber-plastic foam insulation material and a preparation method thereof. The composite rubber-plastic foam insulation material includes a two-layer structure; the two-layer structure includes an insulation layer and a first functional layer; the insulation layer and the first functional layer are both made of a rubber-plastic foam material; the first functional layer and the insulation layer are integrally molded by blending extrusion and vulcanization foaming, and the first functional layer and the insulation layer form an integral structure. The multilayer composite rubber-plastic foam insulation material provided by the present invention adopts a vulcanization foaming integral molding process, and not only ensures the thermal insulation property of the insulation layer, but also gives the functional layer corresponding functions by selecting different functional polymers, thereby satisfying a variety of personalized needs in engineering applications.

Abstract: Methods and systems for secure autonomic optical transport networks are disclosed, including a method of adding a network element in an optical network, comprising: verifying, with a new network element, a first identifier certificate from a proxy network element; verifying, with the proxy network element, a second identifier certificate from the new network element; using a registrar for verifying the second identifier certificate from the proxy network element and sending domain specific parameters to the proxy network element for forwarding to the new network element; generating, on the new network element, a local certificate derived from a secure module and sending it to the proxy network element for forwarding to the registrar; enrolling, with the registrar, the new network element in the autonomic domain; and signing, with the registrar, the local certificate and sending the signed local certificate to the new network element.

Abstract: A 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine are provided. Specifically, a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, in particular as an A2a or A2b receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a or A2b receptor are provided. Each substituent in general formula (I) is defined in the description.

Abstract: A benzofuran derivative, a preparation method thereof and a use thereof in medicine are described. In particular, a benzofuran derivative as shown by general formula (I), the preparation method thereof, a pharmaceutical composition containing the derivative, and uses thereof as an EZH2 inhibitor and in the prevention and/or treatment of diseases such as tumours and cancers, etc., and in particular, uses thereof in the prevention and/or treatment of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and synovial sarcoma, are described.

Abstract: A 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine are provided. Specifically, a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, in particular as an A2a or A2b receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a or A2b receptor are provided. Each substituent in general formula (I) is defined in the description.

Abstract: The present disclosure provides for palonosetron formulations, such as aerosol formulations of palonosetron for pulmonary delivery. Also provided are uses of the formulation, such as reduction, elimination or prevention of nausea and vomiting associated with chemotherapy, radiation therapy, or surgery. Also provided are novel methods to treat chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and post-operative nausea and vomiting (PONY) using the inhalation formulations.