Abstract: Provided are an analytical method of providing an information for diagnosis of a patient who exhibits a response to preoperative chemoradiotherapy in a rectal cancer patient, wherein the expression levels of nine genes, i.e., FGFR3, GNA11, H3F3A, IL12A, IL1R1, IL2RB, NKD1, SGK2, and SPRY2 genes, is analyzed in combination, in carcinoma tissues of a rectal cancer patient, the response (susceptibility) to preoperative chemoradiotherapy can be predicted with high accuracy, and therefore the combination of said genes can be usefully applied as a biomarker for selecting a rectal cancer patient who exhibits a response to preoperative chemoradiotherapy.

Abstract: Systems and methods for monitoring, controlling, and/or reducing demurrage costs are disclosed. A method may comprise causing a computing device to receive and record shipping information for a plurality of shipments to and/or from a plurality of oil and gas wellsites using a plurality of ground transportation units, each shipment having an itinerary of one or more loading actions in one or more corresponding predetermined geographic loading zones and one or more unloading actions in one or more corresponding predetermined geographic unloading zones. The method may further comprise, for each shipment, calculating a loading time spent within each of the predetermined geographic loading zones and an unloading time spent within each of the predetermined geographic unloading zones, and suggesting changes to one or more future portions of a corresponding itinerary for one or more of the plurality of shipments to reduce loading time, unloading time, and/or demurrage costs.