Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.

Abstract: A smart gas emergency gas supply equipment is provided. The smart gas emergency gas supply equipment may be an emergency vehicle including a skid-mounted vehicle, a gas storage tank, an extensible pipeline group, a pressure regulating device, a gasification device, and a control module. The control module may be configured to determine, based on an emergency gas supply plan of the smart gas emergency gas supply device, operating parameters of the pressure regulating device and the gasification device. The emergency gas supply plan at least includes a gas source selection plan and a gas demand, the gas source selection plan may at least include a gas pipeline network crossover and a gas tank direct supply.

Abstract: A semiconductor structure includes: an etch-stop dielectric layer overlying a substrate and including a first opening therethrough; a silicon oxide plate overlying the etch-stop dielectric layer and including a second opening therethrough; a first conductive structure including a first electrode and extending through the second opening and the first opening; a memory film contacting a top surface of the first conductive structure and including a material that provides at least two resistive states having different electrical resistivity; and a second conductive structure including a second electrode and contacting a top surface of the memory film.

Abstract: Provided is a display panel. The display panel includes: a base substrate, a light shielding layer, a buffer layer, an active layer, a gate insulative layer, a gate layer, a first interlayer dielectric layer, and a first conductive layer that are sequentially laminated; wherein the light shielding layer includes a first electrode; the active layer includes a second electrode connected to the first electrode; the gate layer includes a third electrode; and the first conductive layer includes a fourth electrode.

Abstract: Embodiments of this application disclose a three-dimensional audio signal processing method and apparatus, to implement bit allocation of a signal. The method includes: performing spatial coding on a to-be-coded three-dimensional audio signal, to obtain a transmission channel signal and transmission channel attribute information, where the transmission channel signal includes at least one virtual speaker signal group and at least one residual signal group; and determining a bit allocation ratio of the virtual speaker signal group and a bit allocation ratio of the residual signal group based on the transmission channel attribute information.

Abstract: The invention relates to a method for preparing high-stability liquid blueberry anthocyanins, belonging to the field of food processing. A method for preparing high-stability liquid blueberry anthocyanins comprises the following process steps: adding graphene oxide and chitosan to an MES buffer solution at room temperature, mixing homogeneously and adding EDC and NHS sequentially, reacting to obtain a first solution; adding dry blueberry anthocyanin powder in the first solution, adjusting pH to 4.5 to 5.0 and mixing homogeneously to obtain a second solution, and treating the second solution at 350 to 420 MPa and 2 to 4° C. to obtain the product. The method for increasing the stability of blueberry anthocyanins provided by the present invention uses dry blueberry anthocyanin powder as a raw material and adds graphene oxide combined with chitosan compound as an anthocyanin stabilizer, thereby increasing the stability of blueberry anthocyanins during processing and production.

Abstract: A stable dispersant and an application thereof in preparing copolymer polyols, the preparation method for the stable dispersant including the steps of 1) contacting a polyol with a dianhydride compound for reaction so as to prepare an adduct; 2) performing a ring-opening addition reaction on the adduct obtained in step 1) and an epoxy compound to prepare a stable dispersant; the dianhydride compound does not contain a double bond that may copolymerize with an olefinically unsaturated monomer, while the epoxy compound contains a double bond that may copolymerize with an olefinically unsaturated monomer, the polyol is a polyester polyol and/or a polyether polyol, preferably being a polyether polyol. The stable dispersant obtained by means of the described preparation method has a multi-active site anchoring function, and is applied to the synthesis of copolymer polyols to obtain copolymer polyols having relatively uniform particle size.

Abstract: A method, an apparatus for real-time multimedia communications using a software-defined network (SDN) are provided. The method includes receiving, in a periodic manner, a path metric associated with a first service node in the SDN and a second service node in the SDN, wherein the path metric comprises at least one of: a load status of at least one of the first service node or the second service node, or a transmission metric between the first service node and the second service node; and in response to receiving the path metric, updating a cascade network topology comprising an optimal path for transmitting multimedia data between a first edge node and a second edge node.

Abstract: A method for making a spatio-temporal combined optimal scheduling strategy of a mobile energy storage (MES) system includes: inputting data of a power system, a traffic system, and an MES system; setting a time interval, and initializing a time interval counter; inputting real-time fault, traffic, and MES data; and performing rolling optimization and solving, and delivering regulation decision instructions of the MES system, till a fault is removed. The core of the present disclosure is to propose a spatio-temporal combined optimal model of the MES system to describe spatio-temporal coupling statuses of an energy storage vehicle, a traffic network, and a power distribution network. The present disclosure provides guidance for an optimal scheduling decision of the MES system by properly regulating a traveling path and charging and discharging power of the MES system, thereby supporting high-reliability operation of the power distribution network.

Abstract: A device for removing unwanted objects from cut tobacco in a cut tobacco production line is disclosed, which includes: a raw cut tobacco feeding and conveying unit (N1), a heavy unwanted object removal unit (N2), a cut tobacco dispersion and recovery unit (N3), a moderate unwanted object removal unit (N4), a cut tobacco humidification unit (N5) and a light unwanted object removal unit (N6). An unwanted object removal method using the cut tobacco unwanted object removal device is also disclosed. The device and method of the disclosure can effectively remove unwanted objects from cut tobacco.

Abstract: Disclosed is a tricyclic ubiquitin specific protease 1 inhibitor compound, a pharmaceutically acceptable salt thereof, an ester thereof, a deuterated compound or a stereoisomer thereof; a pharmaceutical composition and a formulation containing the compound, the pharmaceutically acceptable salt thereof, the ester thereof, the deuterated compound or the stereoisomer thereof; a method for preparing the compound, the pharmaceutically acceptable salt thereof, the ester thereof, the deuterated compound or the stereoisomer thereof; and use of the compound, the pharmaceutically acceptable salt thereof, the ester thereof, the deuterated compound or the stereoisomer thereof in the manufacture of a medicament for treating and/or preventing a disease mediated by USP1 and a disease related thereto.

Abstract: Block data load with transpose techniques are described. In one example, an input is received, at a control unit, specifying an instruction to load a block of data to at least one memory module using a transpose operation. Responsive to the receiving the input by the control unit, the block of data is caused to be loaded to the at least one memory module by transposing the block of data to form a transposed block of data and storing the transposed block of data in the at least one memory.

Abstract: A switched-mode power supply (SMPS) chip and system are disclosed, which are used for determining a maximum power output of a solar photovoltaic panel connected to the SMPS chip. The SMPS chip includes a sampled current comparator module, a logic control module connected to the sampled current comparator module, and a charge/discharge control module connected to the logic control module. According to the present invention, an output current from the SMPS system to an external load is detected and serves as a basis for incrementally adjusting a minimum input voltage of the SMPS chip and hence an output voltage of the solar photovoltaic panel. In this way, an output voltage level of solar photovoltaic panel corresponding to the maximum power output thereof under a given condition can be determined. Through keeping the solar photovoltaic panel operating at that output voltage level, it is ensured that the solar photovoltaic panel provides the maximum power output under the given condition.

Abstract: A method to upregulate CD46 cell surface expression and combination therapies for various cancers employing an anti-CD46 antibody and an immunomodulatory imide drug (IMiD) or a Signal Transducer And Activator of Transcription 3 (STAT3) inhibitor or both are provided.

Abstract: Embodiments of this application disclose a three-dimensional audio signal processing method and apparatus, to implement sound field classification of a three-dimensional audio signal, to accurately identify the three-dimensional audio signal. An embodiment of this application provides a three-dimensional audio signal processing method, including: performing linear decomposition on a current frame of a three-dimensional audio signal, to obtain a linear decomposition result; obtaining, based on the linear decomposition result, a sound field classification parameter corresponding to the current frame; and determining a sound field classification result of the current frame based on the sound field classification parameter.

Abstract: The embodiments of the present disclosure provide a method and smart gas Internet of Things (IoT) system for determining a gas abnormity for a safe gas use. The method is implemented by a smart gas IoT system including a smart gas user platform, a smart gas service platform, a smart gas safety management platform, a smart gas indoor device sensing network platform, and a smart gas indoor device object platform. The method is performed by the smart gas safety management platform, including: receiving request information of a target user, the request information including a request of the target user for analyzing a gas abnormity cause; extracting user data based on the request information, and extracting gas data based on the user data; and determining, based on the user data and the gas data, analysis information of the gas abnormity cause.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.

Abstract: This application discloses a downmixed signal calculation method and apparatus. The method includes: when a current frame or a previous frame of the current frame of a stereo signal is not a switching frame and a residual signal in the current frame or the previous frame does not need to be encoded, obtaining a second downmixed signal in the current frame and a downmix compensation factor of the current frame, correcting the second downmixed signal in the current frame based on the downmix compensation factor of the current frame, to obtain the first downmixed signal in the current frame and determining the first downmixed signal in the current frame as a downmixed signal in the current frame in a preset frequency band.

Abstract: A condensation-recovery device for overpressure gas based on liquefied natural gas (LNG) cold energy, including a tank body and a condensation cavity provided on a bottom thereof. LNG is stored in the condensation cavity to condense boil-off gas (BOG). The condensation cavity includes a vertical hollow tube arranged in the tank body, and an engagement mechanism is provided on a bottom of the vertical hollow tube. The vertical hollow tube is configured such that the gas can experience preliminary contact with the LNG when flowing therein, and the gas will continuously enter the vertical hollow tube under the action of pressure difference. After entering the conical tube, the gas will be distributed along the cavity of the conical tube to spread downward, so as to increase a contact time of the gas and the LNG while avoiding expanding diffusion area of the gas after entering the LNG.