Abstract: Disclosed is a Flammlina filiformis with a fruiting body of a golden cap and a white stipe. The Flammlina filiformis has a strain number of “Jin Jin No. 1” and has been preserved on Jun. 16, 2022 at the China General Microbiological Culture Collection Center with a registration number of CGMCC No. 40222. Colors of the cap and the stipe of the Flammlina filiformis “Jin Jin No. 1” have obvious differences. Compared with a parent white Flammlina filiformis strain F0012, the Flammlina filiformis “Jin Jin No. 1” has an equivalent average yield, an initial harvest period 1-2 days late, and a golden cap.

Abstract: A configurable electrical connector. The electrical connector includes conductors held by a housing. Contact tails of the conductors extend from a mounting face of the housing therethrough. The mounting face of the housing includes a slot. In some embodiments, the slot exposes portions of ground conductors of the connector and receives a member coupled with the exposed portions of the ground conductors such that the electrical connector can meet high performance requirements. The member may be inserted into or molded in the slot. In some embodiments, the slot may or may not receive a member that is insulative when the electrical connector does not need to meet the high performance requirements. Such a configuration enables the same connector to be compatible with multiple performance protocols.

Abstract: The present disclosure provides anti-CD24 antibody, and anti-CD24/CD47 bispecific antibody molecules, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof

Abstract: The present disclosure relates to novel compounds useful as inhibitors of ATR kinase, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical compositions.

Abstract: The present disclosure relates to novel compounds useful as inhibitors of ATR kinase, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical compositions.

Abstract: Provided are novel compounds useful as inhibitors of the KRAS protein, as well as pharmaceutical compositions comprising these compounds and methods of treatment by administration of these compounds or the pharmaceutical compositions.

Abstract: A shared electronic device management method is implemented in a shared electronic device management device. The method includes receiving a function instruction, obtaining verification information, linking the obtained verification information to verification information in a database, determining whether the obtained verification information meets a first preset condition, implementing the function instruction if the obtained verification information meets the first preset condition, and outputting a prompt if the obtained verification information does not meet the first preset condition. The function instruction includes any one of retrieving, depositing, and repairing a shared electronic device. The verification information includes user verification information and shared electronic device verification information.

Abstract: A correction method for a microseism interpretation fracturing fracture parameter result. The method includes classifying the communication modes of a block sampling fractured wells to be corrected according to the matching degree of micro seismic monitoring result and sand adding amount; correcting the volume coefficient of each said classified fractured well single well, and the volume correction coefficient By of each said fractured well is: B v = [ L 5 / 4 ? H ] T [ L 5 / 4 ? H ] W , wherein, [L5/4H]W is a calculation value of a micro seismic monitoring interpretation result; [L5/4H]T is a theoretical calculation value obtained by using field construction parameters; C, calculating the classification volume correction coefficient of each class of fractured wells according to the calculated single well volume correction coefficient of each said fractured well.

Abstract: A modeling method is provided. The modeling method includes: extracting multiple pieces of logging data corresponding to a plurality of logging characteristic parameters at different drilling depths of a sample well, based on a logging information of the sample well; marking the different drilling depths based on a lost circulation information of the sample well to distinguish lost circulation points and non-lost circulation points; and classifying the lost circulation points and the non-lost circulation points by adopting a random forest algorithm, based on the plurality of logging characteristic parameters and the multiple pieces of marked logging data at the different drilling depths, to establish a plurality of corresponding relations between the logging characteristic parameters and a lost circulation or non-lost circulation result, so as to obtain a diagnosis model.

Abstract: Antibodies having binding specificity to CD44 v7/8, (a.k.a. CD44 variant 7/8) and antibody-drug conjugates (ADCs) or chimeric antigen receptors comprising such. Also provided herein are uses the anti-CD44 v7/8 antibodies, the ADCs, or immune cells expressing the chimeric antigen receptors for therapeutic and diagnostic purposes.

Abstract: Antibodies specific to MUC18 (a.k.a. MCAM or CD146) and uses thereof for therapeutic and diagnostic purposes are provided. Also provided herein are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds MUC18 and immune cells expressing such.

Abstract: Antibodies specific to MUC18 (a.k.a. MCAM or CD146) and antibody-drug conjugates (ADCs) comprising such. Also provided herein are uses the the anti-MUC18 antibodies or ADCs for therapeutic and diagnostic purposes.

Abstract: Antibodies specific to folate receptor alpha (a.k.a. folate receptor 1 or FOLR1) and uses thereof for therapeutic and diagnostic purposes. Also provided herein are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds FOLR1 and immune cells expressing such.

Abstract: Antibodies specific to trophoblast antigen 2 (TROP2) and uses thereof for therapeutic and diagnostic purposes. Also provided are chimeric antigen receptors (CARs) comprising an extracellular antigen-binding fragment that binds TROP2 and immune cells expressing such.

Abstract: The invention described herein provides antibodies or antigen-binding fragment thereof specific for an epitope within the variant exon v6 or v9 of the CD44 gene (CD44v6 or CD44v9), antibody-drug-conjugate (ADC) thereof, and other derivative comprising the antibodies or antigen-binding fragment thereof. The invention also provides nucleic acid molecules encoding the same, and methods of making the same. The invention further provides pharmaceutical compositions comprising the same, and the use of the same in treating diseases or in the manufacture of a medicament for the treatment of the diseases, such as cancer.

Abstract: A shared electronic device management method is implemented in a shared electronic device management device. The method includes receiving a function instruction, obtaining verification information, linking the obtained verification information to verification information in a database, determining whether the obtained verification information meets a first preset condition, implementing the function instruction if the obtained verification information meets the first preset condition, and outputting a prompt if the obtained verification information does not meet the first preset condition. The function instruction includes any one of retrieving, depositing, and repairing a shared electronic device. The verification information includes user verification information and shared electronic device verification information.

Abstract: A modeling method is provided. The modeling method includes: extracting multiple pieces of logging data corresponding to a plurality of logging characteristic parameters at different drilling depths of a sample well, based on a logging information of the sample well; marking the different drilling depths based on a lost circulation information of the sample well to distinguish lost circulation points and non-lost circulation points; and classifying the lost circulation points and the non-lost circulation points by adopting a random forest algorithm, based on the plurality of logging characteristic parameters and the multiple pieces of marked logging data at the different drilling depths, to establish a plurality of corresponding relations between the logging characteristic parameters and a lost circulation or non-lost circulation result, so as to obtain a diagnosis model.

Abstract: Apparatus and method for a physical simulation experiment of fracturing an unconventional oil and gas reservoir layer by layer by spiral perforation via a horizontal well bore. The apparatus includes an outer wellbore provided with at least three layers of spiral perforations, and an inner wellbore provided with at least three layers of through-holes. The method includes injecting fracturing fluid into the inner wellbore, and opening a first layer cracks of a stratum by the fracturing fluid passing the first through-hole layer and the first spiral perforation layer, opening a second layer cracks of the stratum by the fracturing fluid passing second through-hole layer and second spiral perforation layer and opening a third layer cracks of the stratum by the fracturing fluid passing third through-hole layer and third spiral perforation layer.

Abstract: Apparatus and method for a physical simulation experiment of fracturing an unconventional oil and gas reservoir layer by layer by spiral perforation via a horizontal well bore. The apparatus includes an outer wellbore provided with at least three layers of spiral perforations, and an inner wellbore provided with at least three layers of through-holes. The method includes injecting fracturing fluid into the inner wellbore, and opening a first layer cracks of a stratum by the fracturing fluid passing the first through-hole layer and the first spiral perforation layer, opening a second layer cracks of the stratum by the fracturing fluid passing second through-hole layer and second spiral perforation layer and opening a third layer cracks of the stratum by the fracturing fluid passing third through-hole layer and third spiral perforation layer.