Patents by Inventor Bing Shi

Bing Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Co-crystals, salts and solid forms of tenofovir alafenamide
    Patent number: 10155781
    Abstract: The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: December 18, 2018
    Assignee: Gilead Sciences, Inc.
    Inventors: Bing Shi, Zhuoyi Su, Fang Wang
  • CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20180265530
    Abstract: The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: January 29, 2018
    Publication date: September 20, 2018
    Inventors: Chiajen Lai, Bing Shi, Robert G. Strickley
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20180251464
    Abstract: Provided are forms of 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one, compositions thereof, methods for their preparation, and methods for their use.
    Type: Application
    Filed: February 23, 2018
    Publication date: September 6, 2018
    Inventor: Bing Shi
  • CRYSTALLINE FORMS OF DARUNAVIR
    Publication number: 20180170945
    Abstract: The present invention relates to novel crystalline forms of darunavir, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
    Type: Application
    Filed: October 25, 2017
    Publication date: June 21, 2018
    Inventors: Chiajen Lai, Bing Shi
  • CO-CRYSTALS, SALTS AND SOLID FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20180127446
    Abstract: The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds
    Type: Application
    Filed: September 5, 2017
    Publication date: May 10, 2018
    Inventors: Bing Shi, Zhuoyi Su, Fang Wang
  • Solid forms of an antiviral compound
    Patent number: 9884873
    Abstract: Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4?,3?:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using these crystalline forms.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: February 6, 2018
    Assignee: Gilead Pharmasset LLC
    Inventors: Olga Viktorovna Lapina, Bing Shi, Fang Wang, Scott Alan Wolckenhauer
  • SOLID FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20170327488
    Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 16, 2017
    Inventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
  • (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
    Patent number: 9809559
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 7, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Co-crystals, salts and solid forms of tenofovir alafenamide
    Patent number: 9777028
    Abstract: The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 3, 2017
    Assignee: Gilead Sciences, Inc.
    Inventors: Bing Shi, Zhuoyi Su, Fang Wang
  • SOLID FORMS OF AN ANTIVIRAL COMPOUND
    Publication number: 20170247386
    Abstract: Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4?,3?:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using these crystalline forms.
    Type: Application
    Filed: March 15, 2017
    Publication date: August 31, 2017
    Inventors: Olga Viktorovna Lapina, Bing Shi, Fang Wang, Scott Alan Wolckenhauer
  • Solid forms of an antiviral compound
    Patent number: 9682987
    Abstract: Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the amorphous and crystalline forms.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: June 20, 2017
    Assignee: GILEAD PHARMASSET LLC
    Inventors: Erik Mogalian, Robert William Scott, Bing Shi, Fang Wang
  • Solid forms of an antiviral compound
    Patent number: 9630972
    Abstract: Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4?,3?:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using these crystalline forms.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: April 25, 2017
    Assignee: Gilead Pharmasset LLC
    Inventors: Olga Viktorovna Lapina, Bing Shi, Fang Wang, Scott Alan Wolckenhauer
  • SOLID FORMS OF TENOFOVIR
    Publication number: 20170056424
    Abstract: The present invention relates to solid forms of tenofovir and methods for preparation, use and isolation of such forms.
    Type: Application
    Filed: October 5, 2016
    Publication date: March 2, 2017
    Inventors: Paul Bernard HURLEY, Olga Viktorovna LAPINA, Bing SHI, Fang WANG, Zhi Xian WANG, Jacqueline Ching-See WOO
  • POLYMORPHIC FORMS OF (S)-2-(1-(9H-PURIN-6-YLAMINO)PROPYL)-5-FLUORO-3-PHENYLQUINAZOLIN-4(3H)-ONE
    Publication number: 20160376274
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 29, 2016
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry Evarts
  • CO-CRYSTALS, SALTS AND SOLID FORMS OF TENOFOVIR ALAFENAMIDE
    Publication number: 20160368938
    Abstract: The present invention relates to co-crystals, salts and crystalline forms of tenofovir alafenamide and methods for preparation, use and isolation of such compounds
    Type: Application
    Filed: June 13, 2016
    Publication date: December 22, 2016
    Inventors: Bing Shi, Zhuoyi Su, Fang Wang
  • (N-(CYANOMETHYL)-4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE
    Publication number: 20160347719
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Application
    Filed: August 8, 2016
    Publication date: December 1, 2016
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Solid forms of tenofovir
    Patent number: 9487546
    Abstract: The present invention relates to solid forms of tenofovir and methods for preparation, use and isolation of such forms.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: November 8, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Paul Bernard Hurley, Olga Viktorovna Lapina, Bing Shi, Fang Wang, Zhi Xian Wang, Jacqueline Ching-See Woo
  • Polymorphic forms of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
    Patent number: 9469643
    Abstract: Polymorphs of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, compositions thereof, methods for their preparation, and methods for their use are disclosed.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: October 18, 2016
    Assignee: Gilead Calistoga, LLC.
    Inventors: Ernest Carra, Michael Gerber, Bing Shi, Keiko Sujino, Duong Tran, Fang Wang, Jerry B. Evarts
  • (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
    Patent number: 9469613
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 18, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Solid forms of an antiviral compound
    Patent number: 9409891
    Abstract: Crystalline solid forms and the amorphous form of the anti-HCV compound 5-(3,3-dimethylbutyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydrofuran-3-yloxy]methyl}cyclohexyl){[(1R)-4-methylcyclohex-3-en-1-yl]carbonyl}amino]thiophene-2-carboxylic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: August 9, 2016
    Assignee: GILEAD PHARMASSET LLC
    Inventors: Ahmad Hashash, Scott Wolckenhauer, Bing Shi