Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.

Abstract: Methods and apparatuses are provided for video coding. The method includes: partitioning a picture into a plurality of coding units; partitioning a coding unit of the plurality of coding units into two geometric partitions; and performing a predetermined number of motion vector comparison operations during a process of constructing a merging candidate list for either of the two geometric partitions.

Abstract: A method, apparatus, and a non-transitory computer-readable storage medium for decoding a video signal are provided. In one method, a decoder may receive constraint flags, and at least one of the constraint flags indicates whether a slice is an intra slice. The decoder may obtain prediction samples based on the at least one of the constraint flags.

Abstract: Provided herein are linkers, linker-drug groups and anti-body-drug conjugates comprising hydrophilic groups.

Abstract: The present invention relates to the technical field of mobile terminals. Disclosed are an audio signal processing method and apparatus, a device, and a storage medium. The method comprises: when detecting that 3.5 mm earphones are connected by means of a type-C plug of a transfer cable, a mobile terminal determines whether states of audio channels of an audio ground GND and a microphone MIC of the type-C plug are correct. When determining that the states of the audio channels of the GND and the MIC of the type-C plug are correct, the mobile terminal decides whether to enter an audio mode. If the mobile terminal decides to enter the audio mode, a low-resistance network for reducing channel impedance is controlled to connect in parallel to the GND.

Abstract: Anti-CD74 antibody-drug conjugates are disclosed. The anti-CD74 antibody-drug conjugates comprise an Mcl-1 inhibitor drug moiety and an anti-CD74 antibody or antigen-binding fragment thereof that binds an antigen target, e.g., an antigen expressed on a tumor or other cancer cell. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising an Mcl-1 inhibitor drug moiety and methods of making same are also disclosed.

Abstract: A microelectromechanical systems (MEMS) die includes a first diaphragm and a second diaphragm, wherein the first diaphragm and the second diaphragm bound a sealed chamber. A stationary electrode is disposed within the sealed chamber between the first diaphragm and the second diaphragm. A tunnel passes through the first diaphragm and the second diaphragm without passing through the stationary electrode, wherein the tunnel is sealed off from the chamber. The MEMS die further includes a substrate having an opening formed therethrough, wherein the tunnel provides fluid communication from the opening, through the second diaphragm, and through the first diaphragm.

Abstract: Methods and devices are provided for reducing the decoding latency introduced by luma mapping with chroma scaling (LMCS). In one method, during decoding of a coding unit (CU) that is coded by an inter mode or Combined Inter and Intra Prediction (CIIP) mode under LMCS framework, a plurality of reconstructed samples of luma component is obtained in a mapped domain, a plurality of converted samples of luma component is obtained in an original domain by converting the plurality of reconstructed samples of luma component from the mapped domain into the original domain, and the plurality of converted samples of luma component is used in the original domain, without clipping, in deriving chroma scaling factors for decoding the chroma samples of the CU.

Abstract: An electronic apparatus performs a method of decoding video data.

Abstract: Methods and devices are provided for reducing the decoding latency introduced by LMCS. In one method, during decoding of a coding unit (CU), a plurality of reconstructed luma samples is selected from a first pre-determined region neighboring to a second pre-determined region where the CU is located, an average of the plurality of reconstructed luma samples is calculated, and the average of the plurality of reconstructed luma samples is used directly, without any clipping, in deriving a chroma residual scaling factor for decoding the CU.

Abstract: Methods and apparatuses for video coding are provided. The method includes that a decoder determines whether a disable flag is present in a picture header (PH) associated with a picture, wherein the disable flag specifies whether a coding tool is disabled in one or more slices associated with the PH. Additionally, the method includes that the decoder infers value of the disable flag according to one or more enable flags signaled in a sequence parameter set (SPS) of the picture in response to determining that the disable flag is not present in the PH, inferring, by the decoder.

Abstract: Disclosed are a method and device for determining an icon position. The method includes: detecting a target object in a target image and determining the reference position of the target object in the target image, and detecting a salient position in the target image, thereby obtaining the reference position of a key target or object in the target image, and a salient position possibly requiring more attention in the target image; and selecting, according to the distance between the reference position or salient position and preset candidate positions, an icon position from the candidate positions.

Abstract: Methods, apparatuses, and non-transitory computer-readable storage medium are provided for decoding video signals. A decoder receives a bitstream that includes a sequence parameter set (SPS) for video data. The decoder obtains arranged partition constraint syntax elements in sequence parameter set (SPS) level, and the arranged partition constraint syntax elements include intra prediction related syntax elements and inter prediction related syntax elements, and the arranged partition constraint syntax elements are arranged so that the intra prediction related syntax elements are defined before the inter prediction related syntax elements. The decoder decodes the video data based on the arranged partition constraint syntax elements.

Abstract: Methods and apparatuses for video coding are provided. The method includes that a decoder determines whether one or more reference picture lists are signaled in a picture header (PH) associated with a picture and whether the one or more reference picture lists indicate that one or more slices associated with the picture are bi-predictive. The method further includes that the decoder adds one or more constraints to one or more syntax elements in the PH in response to determining that the one or more reference picture lists are signaled in the PH and the one or more reference picture lists indicate that the one or more slices are not bi-predictive.

Abstract: Methods, apparatuses, and non-transitory computer-readable storage mediums are provided for decoding a video signal. A decoder obtains a reference picture I associated with a video block within the video signal. The decoder may further obtain reference samples I(i,j) of the video block from a reference block in the reference picture I. The decoder may also obtain a first down-sampling filter and a second down-sampling filter to respectively generate luma and chroma inter prediction samples of the video block. The decoder may further obtain a third down-sampling filter and a fourth down-sampling filter to respectively generate the luma and chroma inter prediction samples of the video block when the video block is coded by affine mode. The decoder may also obtain inter prediction samples of the video block based on the third and fourth down-sampling filters being applied to the reference samples I(i,j).

Abstract: An electronic apparatus performs a method of decoding video data. The method comprises: receiving, from the bitstream, a plurality of syntax elements associated with a coding unit, wherein the plurality of syntax elements indicate the coding tree type of the coding unit, and whether the local dual tree mode is enabled for the coding unit; and in accordance with the determination that the coding tree type of the coding unit is a single tree, and the local dual tree mode is enabled for the coding unit: disabling the palette mode for the coding unit when the coding unit has the size equal to or less than a predefined threshold. In some embodiments, disabling palette mode for the coding unit includes: disabling the palette mode for both the luma component and chroma component of the coding unit, or disabling the palette mode for only the chroma component of the coding unit.

Abstract: A method for treating a skin wound of a subject is described. The method includes contacting the skin wound with a therapeutically effective amount of a wound healing composition comprising glycoprotein nonmelanoma clone B (GPNMB) protein, an active peptide fragment thereof, a GPNMB analog, a GPNMB potentiating agent, or a combination thereof.

Abstract: An electronic apparatus performs a method of coding video data. The method includes receiving, from a bitstream of the video data, a first syntax that indicates an affine motion model enabled for a current coding block, estimating parameters of the affine motion model using gradients of motion vectors of multiple spatial neighboring blocks of the current coding block, and constructing motion vectors of the affine motion model for the current coding block by using the estimated parameters. In some embodiments, constructing motion vectors further includes converting the estimated parameters into control point motion vectors (CPMVs), and adding the CPMVs into a current affine merge candidate list. In some embodiments, constructing motion vectors further includes deriving a motion vector predictor for an affine mode.

Abstract: The present disclosure relates to a method and device for adjusting a bit rate during live streaming. In the method for adjusting the bit rate during live streaming includes: a parameter of a network used by an anchor terminal for transmitting live streaming data is acquired, an adjustment range of the bit rate for uploading the live streaming data is determined based on the parameter of the network used by the anchor terminal for transmitting the live streaming data, and the bit rate for uploading the live streaming data by the anchor terminal is adjusted based on a determined adjustment range.

Abstract: The present disclosure relates to a method and device for adjusting a bit rate during live streaming. In the method for adjusting the bit rate during live streaming includes: a parameter of a network used by an anchor terminal for transmitting live streaming data is acquired, an adjustment range of the bit rate for uploading the live streaming data is determined based on the parameter of the network used by the anchor terminal for transmitting the live streaming data, and the bit rate for uploading the live streaming data by the anchor terminal is adjusted based on a determined adjustment range.