Abstract: A nano-composite includes a thermoplastic copolymer includes a polycarbonate copolymer including repeating siloxane units and a plurality of quantum dots. A method of making a polymer film includes forming a masterbatch composition by combining (1) a first thermoplastic copolymer including a polycarbonate copolymer including repeating siloxane units and (2) a plurality of quantum dots; combining the masterbatch composition with a second thermoplastic polymer to form a mixture; and forming the polymer film from the mixture. The polycarbonate copolymer has a siloxane content of from 15 wt % to 65 wt %.

Abstract: Thermoplastic compositions include: (a) from about 30 wt % to about 95 wt % poly(methyl methacrylate) (PMMA); and (b) from about 5 wt % to about 70 wt % of a poly(carbonate-siloxane) copolymer having a siloxane content of from about 25 wt % to about 45 wt %. Methods for making a molded article, include: (a) combining from about 30 wt % to about 95 wt % PMMA and from about 5 wt % to about 70 wt % of a poly(carbonate-siloxane) copolymer having a siloxane content of from about 25 wt % to about 45 wt % to form a blend; (b) melt processing and pelletizing the blend; and (c) injection molding the article from the melt processed and pelletized blend.

Abstract: The present disclosure provides compounds represented by Formula I and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

Abstract: A composite material includes: a substrate layer; a first layer including a thermoplastic material applied to the substrate layer, the first layer having a refractive index greater than 1.2 resulting from application of at least one secondary process to the first layer; and a surface coating including a transparent polymer applied to the first layer. The surface coating has a refractive index of from 1 to 2. Methods for making the composite material and articles including the composite material are also described.

Abstract: An object mapping system and method associated with expedient determination of a location of one or more coordinate points of interest (POI) in a bounded 3D environment is disclosed. The system performs various operations that include creating an initial map comprising unique characteristics associated with a bounded physical environment in response to a request by a user via a computing device. Object recognition analysis is performed in order to determine labels associated with objects using image recognition processing based at least on a user command to locate one or more objects of interest and the unique characteristics associated with the bounded physical environment. A world map representation is generated with editable object tags associated with the one or more objects of interest and the unique characteristics associated with the bounded physical environment.

Abstract: The present disclosure provides fused 1,4-oxazepines and related analogs represented by Formula (I) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, A, and Y are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer.

Abstract: Obtain access to a three-dimensional point cloud representation of an object including poses of a scanning digital camera and corresponding video frames. Down-sample the three-dimensional point cloud representation to obtain a set of region-of-interest candidates. Filter the region-of-interest candidates to select those of the region-of-interest candidates having appearance changes, which distinguish different visual states, as selected regions of interest, based at least in part on the poses of the camera. Generate region of interest images for the selected regions of interest from corresponding ones of the video frames; and train a deep learning recognition model based on the region of interest images. the trained deep learning recognition model can be used, for example, to determine a visual state of the object for repair instructions.

Abstract: The present invention provides a compound represented by formula I, pharmaceutically acceptable salts, enantiomers, diastereomers or racemates thereof, the preparation method thereof, the pharmaceutical composition comprising the same, and the use thereof in the preparation of a medicament for treating a disease or condition mediated by EED and/or PRC2. The compound of the present invention can be used treating PRC2-mediated diseases or conditions.

Abstract: A polycarbonate copolymer contains aromatic carbonate units; optionally siloxane units; and resorcinol arylate ester units. The resorcinol arylate ester units of the polycarbonate copolymer are derived from a resorcinol composition having a hydroquinone content of 50 to 1200 parts per million, a catechol content of 5 to 29 parts per million, and a phenol content of 0 to 2400, each as determined by high performance liquid chromatography, and further comprising an acid stabilizer.

Abstract: A method to detect chromatin-interacting RNAs in any given state of a cell or tissue by examining global RNA interactions with DNA by deep sequencing. A method to generate a global view of chromatin-RNA interactome by mapping the binding locations on the genome of each detected chromatin interacting RNA.

Abstract: The present disclosure provides compounds represented by Formula I: I, and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

Abstract: Disclosed is a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by the general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereoisomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising same and use thereof in the treatment of various HAT-related diseases or conditions.

Abstract: An air conditioning system, including a compressor, two outdoor heat exchange units, a liquid pipe used for communicating with indoor units, a high-pressure gas tube and a low-pressure gas tube; the air conditioning system further includes a valve assembly. One outdoor heat exchange unit has a first state in which one end thereof communicates with the high-pressure gas tube and another end thereof communicates with the liquid pipe, and has a second state in which one end thereof communicates with the low-pressure gas tube and the other end thereof communicates with the liquid pipe. Further disclosed is a control method for the air conditioning system.

Abstract: A computer system, non-transitory computer storage medium, and a computer-implemented method of assessing technical risk using visual pattern recognition in an Information Technology (IT) Service Management System. A data visualization engine and a time series generation engine receive the operational data, respectively. A first representation of the data is generated by the data visualization engine, and a second representation of the data is generated by the time series generation engine. Anomaly patterns are identified by a pattern recognition engine configured to perform feature extraction and data transformation. An ensembler is configured to accept the outputs from two AI anomaly engines and make a final decision of whether anomaly patterns are captured. Risk scores based on the identified anomaly patterns are output by a pattern recognition engine to an automated management system. The anomalies includes information regarding vulnerabilities of devices or components of the IT Service Management System.

Abstract: A method, computer system, and a computer program product for intelligently generating an augmented reality (AR)-assisted repair guidance for a user is provided. The present invention may include detecting a scan of an object. The present invention may then include filtering one or more pose-controlled video frames. The present invention may also include extracting at least one new image feature by utilizing a convolutional neural network (CNN) based on the filtered one or more pose-controlled video frames. The present invention may also include aggregating a plurality of visual information associated with the object by utilizing the CNN, wherein the extracted at least one new image feature is included in the aggregated plurality of visual information. The present invention may further include presenting three dimensional (3D) animated instructions to the user, wherein the 3D animated instructions include an AR-assisted repair guidance for the object.

Abstract: A device for making polybutylene terephthalate includes (1) a slurry paste vessel; (2) a tower reactor to which a mixture of 1,4-butane diol and terephthalic acid from vessel (1) is supplied, the tower reactor having a plurality of reactor zones wherein the lower third of the tower reactor is in the form of a hydrocyclone with attached heat exchanger, and the hydrocyclone has a supply line from vessel (1), the hydrocyclone being connected to the top side of the tower reactor; (3) a first continuously stirred tank reactor to which the product from tower reactor (2) is supplied; (4) an optional second continuously stirred tank reactor to which the product from (3) is supplied; (5) a dual shaft ring reactor to which the product from stirred tank reactor (3) or (4), is supplied; and (6) a pelletizer where the product from dual shaft ring reactor (5) is continuously fed and pelletized.

Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.

Abstract: A multi-layer film may comprise a first quantum dot layer comprising a first polymer matrix and a plurality of first quantum dots disposed therein. A second quantum dot layer may be disposed adjacent the first quantum dot layer and may comprise a second polymer matrix and a plurality of second quantum dots disposed therein. The plurality of first quantum dots may be spaced from each other within the first polymer matrix to define gaps there between. The plurality of first quantum dots may emit a first secondary light upon excitation by light produced from a light source. At least a portion of the plurality of second quantum dots may be positioned to align with the gaps defined in the first polymer matrix along an axis that is orthogonal to the first quantum dot layer and the second quantum dot layer.

Abstract: A polycarbonate copolymer comprises aromatic carbonate units; optionally siloxane units; and resorcinol arylate ester units derived from a resorcinol composition having a hydroquinone content of 50 to 1200 parts per million, a catechol content of 5 to 29 parts per million, and a phenol content of 0 to 2400, each as determined by high performance liquid chromatography, and further comprising an acid stabilizer.

Abstract: The present invention relates to a bromodomain inhibitor. Provided are a compound represented by general formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, atropisomer, racemate, polymorph, solvate, or isotopically labeled compound (including deuterium substitution) thereof, a preparation method of the same, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof.