Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: The invention relates to a head module for a rail vehicle, said head module being suitable to be detachably fixed to the front face of a subsequent railcar unit without additional underframe. The head module consists of an inner and an outer shell and includes three systems which convert, in the event of a crash, the collision energy into a deformation one after the other or simultaneously and substantially independently of another.

Abstract: The disclosure provides a seat mounting structure and a train having same. The seat mounting structure includes a seat body (10), a side wall mounting member (20) and a suspension mounting rod (40), wherein a first end of the seat body is connected to a carriage side wall (30) by the side wall mounting member; one end of the suspension mounting rod is connected to a carriage roof, and the other end of the suspension mounting rod is connected to a second end of the seat body; wherein the first end of the seat body is one end, close to the carriage side wall, of the seat body, and the second end of the seat body is one end, away from the carriage side wall, of the seat body. The seat mounting structure provides an effective support for a suspension seat to improve a structural strength of the suspension seat.

Abstract: The invention relates to a head module for a rail vehicle, said head module being suitable to be detachably fixed to the front face of a subsequent railcar unit without additional underframe. The head module consists of an inner and an outer shell and includes three systems which convert, in the event of a crash, the collision energy into a deformation one after the other or simultaneously and substantially independently of another.

Abstract: Provided are a sunshade device and a railway vehicle with the sunshade device. The sunshade device includes: a main sunshading board, the main sunshading board being provided with an avoiding space; and an auxiliary sunshading board, the auxiliary sunshading board being mounted on the main sunshading board in a position adjustable manner, so as to shield or avoid the avoiding space.

Abstract: A securing system for a freight wagon and a freight wagon are provided. The securing system includes an entrance area floor and non-entrance area floor in the freight wagon, multiple first rolling mechanisms and multiple turn position-limiting mechanisms are provided on the entrance area floor, multiple second rolling mechanisms, multiple turn position-limiting mechanisms, multiple lateral position-limiting mechanisms and multiple end position-limiting mechanisms are provided on the non-entrance area floor. With the technical solutions of the present application, loading, conveying and securing of cargo can be achieved in the shortest time on the basis of ensuring the safety and reliability of the transportation, and compared with the conventional cargo loading, the transport efficiency of the cargo is significantly increased and the cost is reduced efficiently.

Abstract: A securing system for a freight wagon and a freight wagon are provided. The securing system includes an entrance area floor and non-entrance area floor in the freight wagon, multiple first rolling mechanisms and multiple turn position-limiting mechanisms are provided on the entrance area floor, multiple second rolling mechanisms, multiple turn position-limiting mechanisms, multiple lateral position-limiting mechanisms and multiple end position-limiting mechanisms are provided on the non-entrance area floor. With the technical solutions of the present application, loading, conveying and securing of cargo can be achieved in the shortest time on the basis of ensuring the safety and reliability of the transportation, and compared with the conventional cargo loading, the transport efficiency of the cargo is significantly increased and the cost is reduced efficiently.