Patents by Inventor Binquan Luan
Binquan Luan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150160159Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: ApplicationFiled: February 18, 2015Publication date: June 11, 2015Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
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Publication number: 20150153309Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Inventors: Binquan Luan, Ruhong Zhou
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Publication number: 20150153305Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Inventors: Binquan Luan, Ruhong Zhou
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Patent number: 8986524Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: GrantFiled: January 27, 2012Date of Patent: March 24, 2015Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
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Publication number: 20150068902Abstract: The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.Type: ApplicationFiled: November 17, 2014Publication date: March 12, 2015Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Glenn J. Martyna, Dennis M. Newns, Hongbo Peng, Stanislav Polonsky, Stephen Rossnagel, Gustavo Stolovitzky
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Publication number: 20150037843Abstract: A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.Type: ApplicationFiled: August 28, 2013Publication date: February 5, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ajay K. Royyuru, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
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Publication number: 20150037787Abstract: A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.Type: ApplicationFiled: July 31, 2013Publication date: February 5, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ajay K. Royyuru, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
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Publication number: 20150038691Abstract: A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.Type: ApplicationFiled: August 28, 2013Publication date: February 5, 2015Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ajay K. Royyuru, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
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Patent number: 8945404Abstract: A mechanism is provided for fabricating nanochannels for a nanodevice. Insulating film is deposited on a substrate. A nanowire is patterned on the film. Insulating material is deposited on the nanowire and film. A first circular hole is formed in the insulating material as an inlet, over a first tip of the nanowire to expose the first tip. A second circular hole is formed as an outlet, over a second tip of the nanowire opposite the first tip to expose the second tip. A nanochannel connects the first and second holes by etching away the nanowire via an etchant in the first and the second holes. A first reservoir is attached over the first hole in connection with the nanochannel at a previous location of the first tip. A second reservoir is attached over the second hole in connection with the nanochannel at a previous location of the second tip.Type: GrantFiled: January 10, 2013Date of Patent: February 3, 2015Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Binquan Luan, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
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Patent number: 8940148Abstract: The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.Type: GrantFiled: June 22, 2010Date of Patent: January 27, 2015Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Glenn J. Martyna, Dennis M. Newns, Hongbo Peng, Stanislav Polonsky, Stephen Rossnagel, Gustavo Stolovitzky
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Publication number: 20140318971Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: ApplicationFiled: August 15, 2013Publication date: October 30, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Publication number: 20140318970Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged molecule through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged molecules passing into the opening. The current changes are employed to trigger a bias field increase to cause separation between the ligand and the protein to infer an interaction strength.Type: ApplicationFiled: August 14, 2013Publication date: October 30, 2014Applicant: International Business Machines CorporationInventors: BINQUAN LUAN, RUHONG ZHOU
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Publication number: 20140318962Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged molecule through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged molecules passing into the opening. The current changes are employed to trigger a bias field increase to cause separation between the ligand and the protein to infer an interaction strength.Type: ApplicationFiled: April 30, 2013Publication date: October 30, 2014Applicant: INTERNATIONAL BUSINESS CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Publication number: 20140190932Abstract: A mechanism is provided for fabricating nanochannels for a nanodevice. Insulating film is deposited on a substrate. A nanowire is patterned on the film. Insulating material is deposited on the nanowire and film. A first circular hole is formed in the insulating material as an inlet, over a first tip of the nanowire to expose the first tip. A second circular hole is formed as an outlet, over a second tip of the nanowire opposite the first tip to expose the second tip. A nanochannel connects the first and second holes by etching away the nanowire via an etchant in the first and the second holes. A first reservoir is attached over the first hole in connection with the nanochannel at a previous location of the first tip. A second reservoir is attached over the second hole in connection with the nanochannel at a previous location of the second tip.Type: ApplicationFiled: January 10, 2013Publication date: July 10, 2014Applicant: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Binquan Luan, Gustavo A. Stolovitzky, Chao Wang, Deqiang Wang
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Patent number: 8764968Abstract: A technique for nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.Type: GrantFiled: September 7, 2012Date of Patent: July 1, 2014Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Glenn J. Martyna, Hongbo Peng, Stephen M. Rossnagel, Gustavo A. Stolovitzky, Philip S. Waggoner, George F. Walker
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Patent number: 8767447Abstract: A method of storing a bit at a memory device is disclosed. A memory cell the memory device is formed of a germanium-deficient chalcogenide glass configured to alternate between an amorphous phase and a crystalline phase upon application of a selected voltage, wherein a drift coefficient of the germanium-deficient chalcogenide glass is less than a drift coefficient of an undoped chalcogenide glass. A voltage is applied to the formed memory cell to select one of the amorphous phase and the crystalline phase to store the bit.Type: GrantFiled: June 19, 2012Date of Patent: July 1, 2014Assignee: International Business Machines CorporationInventors: Chung H. Lam, Jing Li, Binquan Luan, Glenn J. Martyna, Dennis M. Newns
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Publication number: 20140174930Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: August 20, 2013Publication date: June 26, 2014Applicant: International Business Machines CorporationInventors: Binquan Luan, Ruhong Zhou
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Publication number: 20140174929Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: December 21, 2012Publication date: June 26, 2014Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 8737121Abstract: A method of storing a bit at a memory device is disclosed. A memory cell the memory device is formed of a germanium-deficient chalcogenide glass configured to alternate between an amorphous phase and a crystalline phase upon application of a selected voltage, wherein a drift coefficient of the germanium-deficient chalcogenide glass is less than a drift coefficient of an undoped chalcogenide glass. A voltage is applied to the formed memory cell to select one of the amorphous phase and the crystalline phase to store the bit.Type: GrantFiled: May 23, 2012Date of Patent: May 27, 2014Assignee: International Business Machines CorporationInventors: Chung H. Lam, Jing Li, Binquan Luan, Glenn J. Martyna, Dennis M. Newns
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Patent number: 8691067Abstract: A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.Type: GrantFiled: September 16, 2011Date of Patent: April 8, 2014Assignee: International Business Machines CorporationInventors: Stefan Harrer, Binquan Luan, Glenn J. Martyna, Hongbo Peng, Stanislav Polonsky, Stephen M. Rossnagel, Ajay k. Royyuru, Gustavo A. Stolovitzky, George F. Walker