Patents by Inventor Birger Lindberg Möller
Birger Lindberg Möller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10900056Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: GrantFiled: July 9, 2019Date of Patent: January 26, 2021Assignees: Danmarks Tekniske Universitet, Københavns UniversitetInventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Patent number: 10724012Abstract: An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.Type: GrantFiled: October 15, 2018Date of Patent: July 28, 2020Assignees: Københavns Universitet, Danmarks Tekniske UniversitetInventors: Rubini Maya Kannangara, Mads Bennedsen, Bjørn Madsen, Kim Binderup, Ulf Thrane, Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Birger Lindberg Møller, Finn Thyge Okkels
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Patent number: 10689672Abstract: The invention relates to methods for producing vanillin and related compounds. The methods involve use of a vanillin synthase capable of catalyzing side chain cleavage of ferulic acid to form vanillin. The invention also relates to host organisms expressing such vanillin synthases useful in the methods.Type: GrantFiled: November 5, 2013Date of Patent: June 23, 2020Assignees: EVOLVA SA, UNIVERSITY OF COPENHAGENInventors: Birger Lindberg Møller, Esben Halkjaer Hansen, Jørgen Hansen, Nethaji Janeshawari Gallage
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Publication number: 20200040367Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: ApplicationFiled: July 9, 2019Publication date: February 6, 2020Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Patent number: 10519460Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.Type: GrantFiled: June 10, 2016Date of Patent: December 31, 2019Assignees: DANMARKS TENISKE UNIVESITET, KØBENHAVNS UNIVERSITET, CHR. HANSEN NATURAL COLORS A/SInventors: Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Hilde Cornelijne Coumou, Rubini Maya Kannangara, Bjørn Madsen, Majse Nafisi, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Finn Thyge Okkels, Paiman Khorsand-Jamal, Dan Stærk, Birger Lindberg Møller
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Patent number: 10415066Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: GrantFiled: June 10, 2016Date of Patent: September 17, 2019Assignees: Danmarks Tekniske Universitet, Københavns UniversitetInventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Publication number: 20190127767Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).Type: ApplicationFiled: June 10, 2016Publication date: May 2, 2019Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
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Patent number: 10240173Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.Type: GrantFiled: July 10, 2018Date of Patent: March 26, 2019Assignees: University of Copenhagen, Danmarks Tekniske Universitet, Evolva SAInventors: Björn Hamberger, Birger Lindberg Møller, Eirini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen
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Publication number: 20190048328Abstract: An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Applicants: Københavns Universitet, Danmarks Tekniske UniversitetInventors: Rubini Maya Kannangara, Mads Bennedsen, Bjørn Madsen, Kim Binderup, Ulf Thrane, Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Birger Lindberg Møller, Finn Thyge Okkels
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Publication number: 20190010527Abstract: The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.Type: ApplicationFiled: July 10, 2018Publication date: January 10, 2019Inventors: Björn Hamberger, Birger Lindberg Møller, Eirini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen
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Publication number: 20180305709Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.Type: ApplicationFiled: June 10, 2016Publication date: October 25, 2018Applicants: DANMARKS TEKNISKE UNIVERSITET, KØBENHAVNS UNIVERSITET, KØBENHAVNS UNIVERSITETInventors: Rasmus John Normand FRANDSEN, Uffe Hasbro MORTENSEN, Hilde Cornelijne COUMOU, Rubini Maya KANNANGARA, Bjørn MADSEN, Majse NAFISI, Johan ANDERSEN-RANBERG, Kenneth Thermann KONGSTAD, Finn Thyge OKKELS, Paiman KHORSAND-JAMAL, Dan STÆRK, Birger Lindberg MØLLER
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Patent number: 10100290Abstract: An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.Type: GrantFiled: December 18, 2014Date of Patent: October 16, 2018Assignees: Københavns Universitet, Danmarks Tekniske UniversitetInventors: Rubini Maya Kannangara, Mads Bennedsen, Bjørn Madsen, Kim Binderup, Ulf Thrane, Rasmus John Normand Frandsen, Uffe Hasbro Mortensen, Birger Lindberg Møller, Finn Thyge Okkels
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Publication number: 20180265897Abstract: The invention relates to recombinant microorganisms and methods for producing macrocyclic diterpene or oxidized macrocyclic diterpene.Type: ApplicationFiled: December 30, 2015Publication date: September 20, 2018Inventors: Birger Lindberg Møller, Bjorn Hamberger, Roberta Callari, Dan Luo, Morten Thrane Nielsen
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Patent number: 10053717Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.Type: GrantFiled: January 30, 2015Date of Patent: August 21, 2018Assignees: University of Copenhagen, Danmarks Tekniske Universitet, Evolva SAInventors: Björn Hamberger, Birger Lindberg Møller, Eirini Pateraki, Johan Andersen-Ranberg, Niels Bjerg Jensen
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Publication number: 20180112243Abstract: The invention relates to recombinant microorganisms and methods for producing acetylated diterpenes, including oxidized and/or acetylated oxidized diterpenes such as forskolin.Type: ApplicationFiled: April 14, 2016Publication date: April 26, 2018Inventors: Björn Hamberger, Johan Andersen-Ranberg, Niels Bjerg Jensen, Eirini Pateraki, Birger Lindberg Møller
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Publication number: 20160326557Abstract: The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.Type: ApplicationFiled: January 30, 2015Publication date: November 10, 2016Inventors: Björn HAMBERGER, Birger Lindberg MØLLER, Eirini PATERAKI, Johan ANDERSEN-RANBERG, Niels BJERG JENSEN
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Publication number: 20150267227Abstract: The invention relates to methods for producing vanillin and related compounds. The methods involve use of a vanillin synthase capable of catalyzing side chain cleavage of ferulic acid to form vanillin. The invention also relates to host organisms expressing such vanillin synthases useful in the methods.Type: ApplicationFiled: November 5, 2013Publication date: September 24, 2015Inventors: Birger Lindberg Møller, Esben Halkjaer Hansen, Jørgen Hansen, Nethaji Janeshawari Gallage
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Patent number: 7122657Abstract: The present invention provides DNA molecules coding for a UDP-glucose:alycon-glucosyltransferase conjugating cyanohydrins, terpenoids, phenylderivatives or hexanolderivatives to glucose. Trangenic expression of corresponding genes in plants can be used to influence the biosynthesis of the corresponding glucosides.Type: GrantFiled: November 29, 2000Date of Patent: October 17, 2006Inventors: Birger Lindberg Möller, Peter Höj, Patrik Raymond Jones
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Patent number: 6649814Abstract: Cytochrome P450II dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthethic conversion of aldoximes to nitrils and the conversion of said nitrils to the corresponding cyanohydrins, which are the presursors of cyanogenic glycosides. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.Type: GrantFiled: July 5, 2001Date of Patent: November 18, 2003Assignees: Syngenta Participations AG, Royal Veterinary and Agricultural UniversityInventors: Barbara Ann Halkier, Sören Bak, Rachel Alice Kahn, Birger Lindberg Möller
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Patent number: 6300544Abstract: Cytochrome P450II dependent monooxygenases and DNA molecules encoding these monooxygenases are provided, which are able to catalyze the biosynthetic conversion of aldoximes to nitrils and the conversion of said nitrils to the corresponding cyanohydrins, which are the precursors of cyanogenic glycosides. Moreover, the invention provides methods for obtaining DNA molecules according to the invention and methods for obtaining transgenic plants resistant to insects, acarids, or nematodes or plants with improved nutritive value.Type: GrantFiled: November 12, 1999Date of Patent: October 9, 2001Assignees: Syngenta Participations AG, Royal Veterinary and Agricultural UniversityInventors: Barbara Ann Halkier, Sören Bak, Rachel Alice Kahn, Birger Lindberg Möller
