Patents by Inventor Birgit Kuter-Luks

Birgit Kuter-Luks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHRNA AND SIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE
    Publication number: 20090210955
    Abstract: The present invention relates to a biological entity carrying a regulator construct comprising a specific repressor gene and a responder construct comprising at least one segment corresponding to a short hairpin RNA (shRNA) or corresponding to complementary short interfering RNA (siRNA) strands, said at least one segment being under control of a promoter which contains an operator sequence corresponding to the repressor. The invention further relates to a method for preparing said biological entity and its use.
    Type: Application
    Filed: June 8, 2006
    Publication date: August 20, 2009
    Applicant: ARTEMIS PHARMACEUTICALS GMBH
    Inventors: Jost Seibler, Frieder Schwenk, Birgit Küter-Luks
  • SHRNA AND SIRNA AND MIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE
    Publication number: 20090025097
    Abstract: The present invention relates to a biological entity, notably a rat, carrying a regulator construct comprising a specific repressor gene and a responder construct comprising at least one segment corresponding to a short hairpin RNA (shRNA) or corresponding to complementary short interfering RNA (siRNA) strands or corresponding to miRNA, said at least one segment being under control of a promoter which contains an operator sequence corresponding to the repressor. The invention further relates to a method for preparing said biological entity and its use.
    Type: Application
    Filed: May 9, 2008
    Publication date: January 22, 2009
    Applicant: ARTEMIS PHARMACEUTICALS GMBH
    Inventors: Jost SEIBLER, Frieder SCHWENK, Birgit KUTER-LUKS, Michael BADER, Katarina KOTNIK
  • Sirna mediated gene silencing in transgenic animals
    Publication number: 20060218654
    Abstract: The present invention relates to a process that enables constitutive and inducible gene knock down in living organisms using a short hairpin RNA expression vector integrated into the genome of the organism.
    Type: Application
    Filed: October 10, 2003
    Publication date: September 28, 2006
    Applicant: Artemis Pharmaceuticals GmbH
    Inventors: Jost Seibler, Frieder Schwenk, Ralf Kühn, Birgit Küter-Luks
  • SiRNA mediated gene silencing in transgenic animals
    Publication number: 20050071893
    Abstract: The present invention relates to a process that enables constitutive and inducible gene knock down in living organisms using a short hairpin RNA expression vector integrated into the genome of the organism.
    Type: Application
    Filed: October 15, 2003
    Publication date: March 31, 2005
    Inventors: Jost Seibler, Frieder Schwenk, Ralf Kuhn, Birgit Kuter-Luks
  • Modified recombinase
    Publication number: 20040003420
    Abstract: The present invention concerns a fusion protein comprising a recombinase protein, preferably the site-specific DNA recombinase C31-Int of phage &phgr;C31, and a peptide sequence which directs the nuclear uptake of the fusion protein in eucaryotic cells, and the use of this fusion protein to recombine, invert or delete DNA molecules containing recognition sequences for said recombinase in eucaryotic cells at high efficiency. In addition the invention relates to a cell, preferably a mammalian cell which contains recognition sequences for said recombinase in its genome and wherein the genome is recombined by the action of said fusion protein. Moreover, the invention relates to the use of said cell to study the function of genes and for the creation of transgenic organisms to study gene function at various developmental stages, including the adult.
    Type: Application
    Filed: November 12, 2001
    Publication date: January 1, 2004
    Inventors: Ralf Kuhn, Susanne Felder, Frieder Schwenk, Birgit Kuter-Luks, Nicole Faust