Abstract: The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.

Abstract: An asymmetric sensor having asymmetric electrodes and/or being asymmetrically anchored provides enhanced sensitivity. In example embodiments, part of the electrode on a sensor is etched or removed resulting in enhanced mass-change sensitive resonant modes. In another example embodiment, a sensor is anchored asymmetrically, also resulting in enhanced mass-change sensitive resonant modes. By asymmetrically anchoring a piezoelectric portion of a sensor, resonant bending modes of the sensor can be measured electrically without external instrumentation. Modifying the electrode of a piezoelectric cantilever enables expression of mass-change sensitive resonant modes that normally do not lend themselves to electrical measurement.

Abstract: The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.

Abstract: A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA).

Abstract: A novel dual mode sensor may combine mass-sensing measurements of dynamic-mode cantilevers with electrochemical impedance spectroscopy employed for transduction in sensitive electrochemical biosensors. The integrated design of the sensor may provide simultaneous and continuous measurement of resonant frequency shift and charge transfer resistance of a target analyte bound to a surface of the sensor. Binding of a target analyte to the surface of the sensor may cause charge transfer resistance to increase and the resonant frequency of the sensor to decrease. These simultaneous dynamic modes of the sensor may be utilized to measure an amount of mass of the target analyte accumulated on the surface of the sensor and to reduce and/or eliminate false negative measurement results.

Abstract: Cantilever Sensors made of piezoelectric material may be structured with various configurations of asymmetric anchors as well as asymmetric electrodes. Such asymmetry enables measurement of resonant properties of the cantilever that are otherwise unmeasurable electrically, resulting in significant advantages for ease of measurement. In addition the asymmetry enables expression of torsional and/or lateral modes that are otherwise absent, and these modes also exhibit excellent mass-change sensitivity. The asymmetries may enable resonant mode impedance-coupling.

Abstract: A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA).

Abstract: A change in impedance of a electromechanical resonating sensor is utilized to detect and/or measure a change in mass accumulated on the sensor. The impedance is monitored at a fixed frequency. The fixed frequency may be at or near the resonance frequency of the sensor. In various configurations, the sensor comprises a quartz crystal microbalance sensor or a piezoelectric cantilever sensor.

Abstract: An asymmetric sensor having asymmetric electrodes and/or being asymmetrically anchored provides enhanced sensitivity. In example embodiments, part of the electrode on a sensor is etched or removed resulting in enhanced mass-change sensitive resonant modes. In another example embodiment, a sensor is anchored asymmetrically, also resulting in enhanced mass-change sensitive resonant modes. By asymmetrically anchoring a piezoelectric portion of a sensor, resonant bending modes of the sensor can be measured electrically without external instrumentation. Modifying the electrode of a piezoelectric cantilever enables expression of mass-change sensitive resonant modes that normally do not lend themselves to electrical measurement.

Abstract: A change in impedance of a electromechanical resonating sensor is utilized to detect and/or measure a change in mass accumulated on the sensor. The impedance is monitored at a fixed frequency. The fixed frequency may be at or near the resonance frequency of the sensor. In various configurations, the sensor comprises a quartz crystal microbalance sensor or a piezoelectric cantilever sensor.