Patents by Inventor Bo Damgaard
Bo Damgaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120289450Abstract: The present invention relates to cellulase variants, i.e., endo-beta-1,4-glucanase variants, derived from a parental cellulase, i.e., endo-beta-1,4-glucanase, by substitution, insertion and/or deletion, which variant has a catalytic core domain, in which the variant at position 5 holds an alanine residue (A), a serine residue (S), or a threonine residue (T); at position 8 holds a phenylalanine residue (F), or a tyrosine residue (Y); at position 9 holds a phenylalanine residue (F), a tryptophan residue (W), or a tyrosine residue (Y); at position 10 holds an aspartic acid residue (D); and at position 121 holds an aspartic acid residue (D).Type: ApplicationFiled: May 15, 2012Publication date: November 15, 2012Applicant: NOVOZYMES A/SInventors: Kim Vilbour Andersen, Martin Schülein, Lars Christiansen, Bo Damgaard, Claus Von der Osten
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Publication number: 20110250674Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: ApplicationFiled: June 17, 2011Publication date: October 13, 2011Applicant: Novozymes A/SInventors: Kim Vilbour Andersen, Martin Schülein, Torben Henriksen, Lars Christiansen, Bo Damgaard, Claus Von der Osten
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Patent number: 8017372Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: GrantFiled: July 30, 2007Date of Patent: September 13, 2011Assignee: Novozymes A/SInventors: Kim Vilbour Andersen, Martin Schulein, Torben Henriksen, legal representative, Lars Christiansen, Bo Damgaard, Claus Von der Osten
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Patent number: 7993898Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: GrantFiled: February 27, 2009Date of Patent: August 9, 2011Assignee: Novozymes A/SInventors: Kim Vilbour Andersen, Martin Schulein, Torben Henriksen, legal representative, Lars Christensen, Bo Damgaard, Claus Von der Osten
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Publication number: 20090170747Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: ApplicationFiled: February 27, 2009Publication date: July 2, 2009Applicant: Novozymes A/SInventors: Kim Vilbour Andersen, Martin Schulein, Torben Henriksen, Lars Christensen, Bo Damgaard, Claus Von der Osten
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Publication number: 20080206836Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: ApplicationFiled: July 30, 2007Publication date: August 28, 2008Applicant: Novozymes A/SInventors: Kim Vilbour Andersen, Martin Schulein, Torben Henriksen, Lars Christiansen, Bo Damgaard, Claus Von der Osten
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Publication number: 20050009166Abstract: The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of: a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 ?; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g.Type: ApplicationFiled: August 16, 2004Publication date: January 13, 2005Applicant: Novozymes A/SInventors: Kim Andersen, Martin Schulein, Hanne Dela, Lars Christiansen, Bo Damgaard, Claus Von der Osten
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Publication number: 20030092097Abstract: Described is a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of:Type: ApplicationFiled: March 3, 1999Publication date: May 15, 2003Applicant: NOVOZYME A/SInventors: KIM VILBOUR ANDERSEN, MARTIN SCHULEIN, LARS CHRISTIANSEN, BO DAMGAARD, CLAUS VON DER OSTEN
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Patent number: 5997584Abstract: This invention relates to a method of reducing the pilling propensity or colour clarity of polyester fabrics and/or garments, which method comprises treating the fabric with a polyester hydrolytic enzyme and a detergent.Type: GrantFiled: July 15, 1998Date of Patent: December 7, 1999Assignee: Novo Nordisk A/SInventors: Bente Konggaard Andersen, Kim Borch, Masanobu Abo, Bo Damgaard