Patents by Inventor Bo Shen

Bo Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230151338
    Abstract: Provided are compositions comprising polynucleotides encoding modified diacylglycerol acyltransferase-1 (DGAT1) polypeptides having improved properties, such as increased enzymatic activity and/or increased stability. Plants, plant cells, seed, grain and comprising the polynucleotides are provided which have one or more of increased fatty acid or protein content. Methods of generating the polynucleotides in plant cells include transformation and genetic modification. Methods of employing the polynucleotides in plants, methods for increasing DGAT1 activity in a plant, and methods for increasing fatty acid content or protein content in a plant are provided.
    Type: Application
    Filed: September 19, 2022
    Publication date: May 18, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: KAYLA S FLYCKT, KRISTIN HAUG COLLET, ZHAN-BIN LIU, KEITH R ROESLER, BO SHEN, LAURA L WAYNE
  • Publication number: 20230146129
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Application
    Filed: December 27, 2022
    Publication date: May 11, 2023
    Inventors: Liangxing Wu, Bo Shen, Meizhong Xu, Wenqing Yao
  • Patent number: 11566026
    Abstract: Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: January 31, 2023
    Assignee: Incyte Corporation
    Inventors: Liangxing Wu, Bo Shen, Meizhong Xu, Wenqing Yao
  • Patent number: 11567753
    Abstract: Systems and methods are provided to recommend software patches based on task operation mapping. In embodiments, a method includes abstracting test cases for a software patch into a sequence of task operations and parameters associated with each task operation; encoding the task operations and the parameters associated with each task operation based on predetermined rules, thereby generating encoded task operations with unique identifiers assigned thereto and associated encoded parameters with numeric values assigned thereto; generating, using machine learning, a list of frequent operation items, based on the encoded task operations and the associated encoded parameters; generating, using clustering, clusters of parameters for each frequent operation item in the list of frequent operation items; and sending a software patch package including the list of frequent operation items, the clusters of parameters and the software patch to a remote server for distribution to one or more user devices.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: January 31, 2023
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Lei Gao, Yan Liu, Bo Shen, Zhen Liu, Kai Li, Jin Wang, A Peng Zhang
  • Patent number: 11570082
    Abstract: A computer-implemented method, system and computer program product for accurately identifying an execution time of a performance test. Network latency data is grouped into clustered groups of network latency data. Furthermore, the performance test execution times for the same group of performance tests run in the local and remote cluster environments are obtained. The test execution times impacted by network latency (compensation times) are then determined based on such obtained performance test execution times in the local and remote cluster environments. Such compensation times are then grouped into clustered groups of compensation times. A regression model is built to predict a performance test execution time impacted by network latency (compensation time) using the clustered groups of network latency data and compensation times.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 31, 2023
    Assignee: International Business Machines Corporation
    Inventors: Bo Shen, Yao Dong Liu, Jing James Xu, Lei Gao, Yan Liu
  • Publication number: 20230024164
    Abstract: Provided are compositions comprising polynucleotides encoding BG1 polypeptides. Also provided are recombinant DNA constructs, plants, plant cells, seed, grain comprising the polynucleotides, and plants, plant cells, seed, grain comprising a genetic modification at a genomic locus encoding a BG1 polypeptide. Additionally, various methods of employing the polynucleotides and genetic modifications in plants, such as methods for increasing BG1 level in a plant and methods for increasing yield of a plant and/or drought tolerance, are also provided herein.
    Type: Application
    Filed: December 17, 2020
    Publication date: January 26, 2023
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Bo SHEN, Carl SIMMONS
  • Publication number: 20220380794
    Abstract: The compositions and methods disclosed relate to DNA compositions, plant cells, seeds, plant parts that relate to maize plants with increased grain yield trait. Also provided are assays for detecting the presence of the maize DP-202216-6 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Application
    Filed: June 21, 2022
    Publication date: December 1, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HEATHER MARIE CHRISTENSEN, NATHAN DAVID COLES, OLGA DANILEVSKAYA, JEFFREY HABBEN, MARY A RUPE, JEFFREY R SCHUSSLER, BO SHEN, BENJAMIN P WEERS, JINGRUI WU
  • Publication number: 20220351525
    Abstract: Disclosed herein are systems and methods for alleviating traffic congestion within an enforcement zone. In some embodiments, a system for alleviating traffic congestion within an enforcement zone comprises a server and a plurality of edge devices coupled to carrier vehicles deployed within the enforcement zone. The edge devices can be configured to capture videos of vehicles that may be subject to the traffic congestion pricing policy and to determine their locations, license plate numbers, and certain vehicle attributes using certain sensors on the edge devices and deep learning models running on the edge devices. The edge devices can also be configured to transmit evidence packages to the server concerning such vehicles. The server can be configured to evaluate the evidence packages received from the edge devices and prepare final evidence packages concerning the vehicles for further review and processing.
    Type: Application
    Filed: April 8, 2022
    Publication date: November 3, 2022
    Applicant: Hayden Al Technologies, Inc.
    Inventors: Christopher CARSON, Vaibhav GHADIOK, Bo SHEN
  • Publication number: 20220340923
    Abstract: Soybean plants producing soybean seeds comprising leghemoglobin are produced by modifying the genome of the soybean plant. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin are provided. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin and additionally one or more of high oleic acid, low linolenic acid, high protein, low stachyose, low raffinose and low protease inhibitors are provided. Protein compositions comprising leghemoglobin, such as soy isolates and concentrates can be made from the soybean seeds. Additionally, methods for generating and using plants, seeds and protein compositions comprising leghemoglobin are disclosed.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 27, 2022
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: HYEON-JE CHO, JOHN D EVERARD, ANTHONY J. KINNEY, ZHAN-BIN LIU, KNUT MEYER, THOMAS G PATTERSON, KEVIN G RIPP, BO SHEN
  • Patent number: 11479759
    Abstract: Provided are compositions comprising polynucleotides encoding modified diacylglycerol acyltransferase-1 (DGAT1) polypeptides having improved properties, such as increased enzymatic activity and/or increased stability. Plants, plant cells, seed, grain and comprising the polynucleotides are provided which have one or more of increased fatty acid or protein content. Methods of generating the polynucleotides in plant cells include transformation and genetic modification. Methods of employing the polynucleotides in plants, methods for increasing DGAT1 activity in a plant, and methods for increasing fatty acid content or protein content in a plant are provided.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: October 25, 2022
    Inventors: Kayla S Flyckt, Kristin Haug Collet, Zhan-Bin Liu, Keith R Roesler, Bo Shen, Laura L Wayne
  • Publication number: 20220335824
    Abstract: Disclosed herein are methods and systems that allow users to report traffic violations and obtain information concerning reported violations using mobile devices. In one embodiment, a method comprises receiving, at a server, one or more images or videos captured by a mobile device of an offending vehicle committing a potential traffic violation and an extended metadata tag; storing the one or more images or videos and the extended metadata tag as unstructured content in a content lake; generating database tables on top of the content lake; receiving a request from another mobile device to view traffic violation content; querying the database tables and retrieving at least one of the one or more images or videos of the offending vehicle committing the potential traffic violation from the content lake; and generating a GUI to be displayed via the other mobile device showing the traffic violation content.
    Type: Application
    Filed: October 19, 2021
    Publication date: October 20, 2022
    Applicant: Hayden AI Technologies, Inc.
    Inventors: Christopher Carson, Vaibhav Ghadiok, Bo Shen
  • Patent number: 11475766
    Abstract: Disclosed herein are methods and systems that allow users to report traffic violations and obtain information concerning reported violations using mobile devices. In one embodiment, a method comprises receiving, at a server, one or more images or videos captured by a mobile device of an offending vehicle committing a potential traffic violation and an extended metadata tag; storing the one or more images or videos and the extended metadata tag as unstructured content in a content lake; generating database tables on top of the content lake; receiving a request from another mobile device to view traffic violation content; querying the database tables and retrieving at least one of the one or more images or videos of the offending vehicle committing the potential traffic violation from the content lake; and generating a GUI to be displayed via the other mobile device showing the traffic violation content.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: October 18, 2022
    Assignee: Hayden AI Technologies, Inc.
    Inventors: Christopher Carson, Vaibhav Ghadiok, Bo Shen
  • Patent number: 11421242
    Abstract: The compositions and methods disclosed relate to DNA compositions, plant cells, seeds, plant parts that relate to maize plants with increased grain yield trait. Also provided are assays for detecting the presence of the maize DP-202216-6 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: August 23, 2022
    Inventors: Heather Marie Christensen, Nathan David Coles, Olga Danilevskaya, Jeffrey Habben, Mary A Rupe, Jeffrey R Schussler, Bo Shen, Benjamin P Weers, Jingrui Wu
  • Patent number: 11407749
    Abstract: Disclosed are compounds of Formula (I?), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: August 9, 2022
    Assignee: Incyte Corporation
    Inventors: Liangxing Wu, Bo Shen, Jingwei Li, Zhenwu Li, Kai Liu, Fenglei Zhang, Wenqing Yao
  • Publication number: 20220238012
    Abstract: Disclosed herein are systems and methods for managing traffic rules. In one embodiment, a method of managing traffic rules can comprise generating or updating a semantic map layer based in part on positioning data obtained from one or more edge devices and videos captured by the one or more edge devices. The method can also comprise generating or updating a traffic enforcement layer on top of the semantic map layer. A plurality of traffic rules can be saved as part of the traffic enforcement layer. The method can further comprise generating or updating a traffic insight layer based in part on traffic violations or traffic conditions determined by the one or more edge devices or the server. The traffic insight layer can adjust or provide a suggestion to adjust at least one of the traffic rules based on an impact analysis conducted by the traffic insight layer concerning the traffic rule.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 28, 2022
    Applicant: Hayden AI Technologies, Inc.
    Inventors: Vaibhav GHADIOK, Christopher CARSON, Bo SHEN
  • Patent number: 11359206
    Abstract: Soybean plants producing soybean seeds comprising leghemoglobin are produced by modifying the genome of the soybean plant. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin are provided. Soybean plants, soybean seeds and soy protein compositions comprising leghemoglobin and additionally one or more of high oleic acid, low linolenic acid, high protein, low stachyose, low raffinose and low protease inhibitors are provided. Protein compositions comprising leghemoglobin, such as soy isolates and concentrates can be made from the soybean seeds. Additionally, methods for generating and using plants, seeds and protein compositions comprising leghemoglobin are disclosed.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: June 14, 2022
    Inventors: Hyeon-Je Cho, John D Everard, Anthony J Kinney, Zhan-Bin Liu, Knut Meyer, Thomas G Patterson, Kevin G Ripp, Bo Shen
  • Publication number: 20220147745
    Abstract: Disclosed herein are systems, methods, and devices for detecting traffic lane violations. In one embodiment, a method for detecting a potential traffic violation is disclosed comprising bounding a vehicle detected from one or more video frames of a video in a vehicle bounding box. The vehicle can be detected and bounded using a first convolutional neural network. The method can also comprise bounding, using the one or more processors of the edge device, a plurality of lanes of a roadway detected from the one or more video frames in a plurality of polygons. The plurality of lanes can be detected and bounded using multiple heads of a multi-headed second convolutional neural network. The method can further comprise detecting a potential traffic violation based in part on an overlap of at least part of the vehicle bounding box and at least part of one of the polygons.
    Type: Application
    Filed: October 5, 2021
    Publication date: May 12, 2022
    Applicant: Hayden Al Technologies, Inc.
    Inventors: Vaibhav GHADIOK, Christopher CARSON, Bo SHEN
  • Publication number: 20220144831
    Abstract: This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2?-dimethyl-[1,1?-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Dengjin Wang, Daniel Carper, Zhongjiang Jia, Bo Shen, Joseph A. Sclafani, Robert Wilson, Jiacheng Zhou, Osama Suleiman, Mark Wright
  • Publication number: 20220144830
    Abstract: The present invention relates to processes of preparing PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2?-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, or salts thereof, related synthetic intermediates, and salts of the intermediates, where the PD-1/PD-L1 inhibitor is useful in the treatment of various diseases including infectious diseases and cancer.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Jiacheng Zhou, Shili Chen, Zhongjiang Jia, Yi Li, Qiyan Lin, Pingli Liu, Yongchun Pan, Timothy Martin, Bo Shen, Chongsheng Eric Shi, Naijing Su, Yongzhong Wu, Michael Xia
  • Patent number: 11322017
    Abstract: Disclosed herein are systems and methods for managing traffic rules. In one embodiment, a method of managing traffic rules can comprise generating or updating a semantic map layer based in part on positioning data obtained from one or more edge devices and videos captured by the one or more edge devices. The method can also comprise generating or updating a traffic enforcement layer on top of the semantic map layer. A plurality of traffic rules can be saved as part of the traffic enforcement layer. The method can further comprise generating or updating a traffic insight layer based in part on traffic violations or traffic conditions determined by the one or more edge devices or the server. The traffic insight layer can adjust or provide a suggestion to adjust at least one of the traffic rules based on an impact analysis conducted by the traffic insight layer concerning the traffic rule.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: May 3, 2022
    Assignee: Hayden AI Technologies, Inc.
    Inventors: Vaibhav Ghadiok, Christopher Carson, Bo Shen