Patents by Inventor Bobby Lee Barnett
Bobby Lee Barnett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6599730Abstract: The present invention relates to subtilisin 309 variants having a modified amino acid sequence of wild-type subtilisin 309 amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin 309 (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the subtilisin 309 variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin 309. The present invention also relates to DNA sequence encoding such subtilisin 309 variants. The present invention also relates to compositions comprising such subtilisin 309 variants for cleaning a variety of surfaces.Type: GrantFiled: March 7, 1995Date of Patent: July 29, 2003Assignee: Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh, Chanchal Kamur Ghosh
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Patent number: 6475765Abstract: The present invention relates to Subtilisin DY variants having a modified amino acid sequence of wild-type Subtilisin DY amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Subtilisin DY (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the Subtilisin DY variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Subtilisin DY. The present invention also relates to DNA sequences encoding such Subtilisin DY variants. The present invention also relates to compositions comprising such Subtilisin DY variants for cleaning a variety of surfaces.Type: GrantFiled: March 9, 1995Date of Patent: November 5, 2002Assignee: Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh
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Patent number: 6455295Abstract: The present invention relates to subtilisin Carlsberg variants having a modified amino acid sequence of wild-type subtilisin Carlsberg amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin Carlsberg (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the subtilisin Carlsberg variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin Carlsberg. The present invention also relates to the genes encoding such subtilisin Carlsberg variants. The present invention also relates to compositions comprising such subtilisin Carlsberg variants for cleaning a variety of surfaces.Type: GrantFiled: March 8, 1995Date of Patent: September 24, 2002Assignee: The Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh
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Patent number: 6451574Abstract: The present invention relates to Proteinase K variants having a modified amino acid sequence of wild-type Proteinase K amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Proteinase K (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the Proteinase K variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Proteinase K. The present invention also relates to DNA sequences encoding such Proteinase K variants. The present invention also relates to compositions comprising such Proteinase K variants for cleaning a variety of surfaces.Type: GrantFiled: September 23, 1997Date of Patent: September 17, 2002Assignee: The Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh
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Patent number: 6440717Abstract: The present invention relates to subtilisin BPN′ variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions, whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN′. The present invention further relates to various cleaning compositions comprising such BPN′ variants.Type: GrantFiled: March 2, 1995Date of Patent: August 27, 2002Assignee: The Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh, Chanchal Kumar Ghosh
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Patent number: 6436690Abstract: The present invention relates to subtilisin BPN′ variants having a modified amino acid sequence of wild-type BPN′ amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPN′. The present invention also relates to the genes encoding such subtilisin BPN′ variants. The present invention also relates to compositions comprising such subtilisin BPN′ variants for cleaning a variety of surfaces.Type: GrantFiled: March 3, 1995Date of Patent: August 20, 2002Assignee: The Procter & Gamble CompanyInventors: Philip Frederick Brode, III, Bobby Lee Barnett, Donn Nelton Rubingh, Chanchal Kumar Ghosh
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Patent number: 6017871Abstract: The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).Type: GrantFiled: July 22, 1997Date of Patent: January 25, 2000Assignee: The Procter & Gamble CompanyInventors: Andre Baeck, Chanchal Kumar Ghosh, Thomas Paul Graycar, Richard Ray Bott, Lori Jean Wilson, Philip Frederick Brode, Bobby Lee Barnett, Donn Nelton Rubingh
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Patent number: 5679630Abstract: The present invention relates to cleaning compositions comprising subtilisin proteases from Bacillus lentus having the following alterations: N76D, S103A and V104I, where the numbering is based on the corresponding positions in the subtilisin from Bacillus amyloliquefaciens.Type: GrantFiled: October 13, 1994Date of Patent: October 21, 1997Assignee: The Procter & Gamble CompanyInventors: Andre Baeck, Chanchal Kumar Ghosh, Thomas Paul Graycar, Richard Ray Bott, Lori Jean Wilson, Philip Frederick Brode, Bobby Lee Barnett, Donn Nelton Rubingh