Patents by Inventor Boke Zhang
Boke Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230321071Abstract: An eye-soothing externally-applied liquid medicine includes a phase A, a phase B, an adjuvant and purified water. The phase A includes a western medicine component and a traditional Chinese medicine component by mass. The western medicine component includes at least one of 0.1 g of atropine, 0,1 g of homatropine, and 0.1 g of tropicamide. The traditional Chinese medicine component includes at least one of 0.5 g of a cassia seed extract, 0.5 g of a mulberry leaf extract, 0.2 g of a marigold flower extract, 0.5 g of a fibs albiziae extract, 0.5 g of an eyebright extract, and 0.2 g of a common foxglove leaf extract. The phase B includes 1 g of vitamin A, 0.5 g of vitamin B1, 0.005 g of vitamin B2, 0.001 g of vitamin B12, 0.5 g of adenosine triphosphate, 1 g of vaccinium myrtillus seed oil, and 0.001 g of lutein.Type: ApplicationFiled: November 8, 2022Publication date: October 12, 2023Inventor: Boke Zhang
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Publication number: 20210346292Abstract: The main aspect of present invention is to provide a pharmaceutical composition to increase the stability of liquid formulation of botulinum toxin and related proteins. The present invention provides a method to stabilize toxin in liquid formulation. Lipid based drug delivery system is known to increase the bioavailability of drugs (Amidon et al., 1995; Jannin et al., 2008). We investigated the stability of BoNT/A toxin and complex. We used two formulations in liquid phase: combination of lipids and liposomes, with two different storage conditions: 4° C. and 25° C. The present invention also provides a method for efficient delivery of botulinum toxin through skin as a topical application.Type: ApplicationFiled: May 6, 2020Publication date: November 11, 2021Applicant: Prime Bio, Inc.Inventors: Bal Ram Singh, Raj Kumar, Boke Zhang
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Patent number: 10961523Abstract: A multilayer nano-cell includes an innermost water phase core including biomolecules in an aqueous solution; a first layer, including an oil phase layer encapsulating the innermost water phase core, thereby forming a water-in-oil structure, the oil phase layer including caprylic/capric triglyceride and macrogol-35-glycerol-rizinoleat; a second layer, including a water phase layer encapsulating the first layer, the water phase layer including hyaluronic acid, Cu-GHK tripeptide, palmitoyl-KTTKS pentapeptide, and hexapeptide argireline; a third layer, including another oil phase layer encapsulating the second layer; a fourth layer, including another water phase layer encapsulating the third layer; a fifth layer, including another oil phase layer encapsulating the fourth layer; and a sixth layer, including an outmost cream layer encapsulating the fifth layer.Type: GrantFiled: August 18, 2020Date of Patent: March 30, 2021Inventor: Boke Zhang
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Publication number: 20200392476Abstract: A multilayer nano-cell includes an innermost water phase core including biomolecules in an aqueous solution; a first layer, including an oil phase layer encapsulating the innermost water phase core, thereby forming a water-in-oil structure, the oil phase layer including caprylic/capric triglyceride and macrogol-35-glycerol-rizinoleat; a second layer, including a water phase layer encapsulating the first layer, the water phase layer including hyaluronic acid, Cu-GHK tripeptide, palmitoyl-KTTKS pentapeptide, and hexapeptide argireline; a third layer, including another oil phase layer encapsulating the second layer; a fourth layer, including another water phase layer encapsulating the third layer; a fifth layer, including another oil phase layer encapsulating the fourth layer; and a sixth layer, including an outmost cream layer encapsulating the fifth layer.Type: ApplicationFiled: August 18, 2020Publication date: December 17, 2020Inventor: Boke Zhang
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Patent number: 10851363Abstract: Method for preparing botulinum neurotoxin and nanoparticle thereof are provided. The method includes fermenting bacteria Clostridium botulinum in a fermentation media free of animal-derived ingredients and contacting the fermentation media with an anion exchange media slurry and obtaining a supernatant including the botulinum neurotoxin by centrifugation. The method further includes dialyzing the supernatant and collecting a dialyzed solution including the botulinum neurotoxin, contacting the dialyzed solution with an anion exchange chromatography column, contacting an elute collected from the anion exchange chromatography column with a cation exchange chromatography column, and collecting an elute. The nanoparticle includes multi-layer including an innermost water phase core including biomolecules encapsulated by an oil phase layer, thereby forming a water-in-oil structure, water phase layers; oil phase layers; and an outmost cream layer.Type: GrantFiled: May 22, 2019Date of Patent: December 1, 2020Assignee: Boke ZHANGInventor: Boke Zhang
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Publication number: 20200370031Abstract: Method for preparing botulinum neurotoxin and nanoparticle thereof are provided. The method includes fermenting bacteria Clostridium botulinum in a fermentation media free of animal-derived ingredients and contacting the fermentation media with an anion exchange media slurry and obtaining a supernatant including the botulinum neurotoxin by centrifugation. The method further includes dialyzing the supernatant and collecting a dialyzed solution including the botulinum neurotoxin, contacting the dialyzed solution with an anion exchange chromatography column, contacting an elute collected from the anion exchange chromatography column with a cation exchange chromatography column, and collecting an elute. The nanoparticle includes multi-layer including an innermost water phase core including biomolecules encapsulated by an oil phase layer, thereby forming a water-in-oil structure, water phase layers; oil phase layers; and an outmost cream layer.Type: ApplicationFiled: May 22, 2019Publication date: November 26, 2020Inventor: Boke ZHANG
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Patent number: 10016451Abstract: The present invention provides nanoparticle compositions including one or more nucleic acids. The present invention achieves delivery (particularly transdermal delivery) of such nucleic acids without the need for nucleic acid modification, or for use of chemical or mechanical abrasion or disruption of skin.Type: GrantFiled: May 30, 2008Date of Patent: July 10, 2018Assignee: Anterios, Inc.Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
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Patent number: 9833403Abstract: The invention described herein is related to the preparation and usage of nanoemulsions and nanoparticles which containing biological active ingredients including cosmetic, medical and pharmaceutical active ingredients to pass skin barriers and promote cell growth with evident clinical effects. Also, the present invention contains a cosmetic formulation that can be used for skin rejuvenation, wrinkle removal, scar treatment and wounds healing.Type: GrantFiled: December 31, 2013Date of Patent: December 5, 2017Inventors: Huiwen Liu, Boke Zhang
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Patent number: 9814239Abstract: The invention generally relates to certain antimicrobial, antibacterial, antifungal or antiviral compounds. More particularly, the invention relates to certain antimicrobial antibacterial, antifungal and/or antiviral compounds, their syntheses and compositions, and methods of use thereof.Type: GrantFiled: June 16, 2011Date of Patent: November 14, 2017Inventors: Huiwen Liu, Boke Zhang
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Publication number: 20160213757Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.Type: ApplicationFiled: August 26, 2015Publication date: July 28, 2016Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
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Publication number: 20160120794Abstract: The invention described herein is related to the preparation and usage of nanoemulsions and nanoparticles which containing biological active ingredients including cosmetic, medical and pharmaceutical active ingredients to pass skin barriers and promote cell growth with evident clinical effects. Also, the present invention contains a cosmetic formulation that can be used for skin rejuvenation, wrinkle removal, scar treatment and wounds healing.Type: ApplicationFiled: December 31, 2013Publication date: May 5, 2016Inventors: Huiwen LIU, Boke ZHANG
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Publication number: 20160073636Abstract: The invention generally relates to certain antimicrobial, antibacterial, antifungal or antiviral compounds. More particularly, the invention relates to certain antimicrobial antibacterial, antifungal and/or antiviral compounds, their syntheses and compositions, and methods of use thereof.Type: ApplicationFiled: June 16, 2011Publication date: March 17, 2016Inventors: Huiwen Liu, Boke Zhang
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Publication number: 20110305734Abstract: The present invention provides nanoparticle compositions including one or more nucleic acids. The present invention achieves delivery (particularly transdermal delivery) of such nucleic acids without the need for nucleic acid modification, or for use of chemical or mechanical abrasion or disruption of skin.Type: ApplicationFiled: May 30, 2008Publication date: December 15, 2011Applicant: ANTERIOS, INC.Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
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Publication number: 20110212157Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.Type: ApplicationFiled: June 26, 2009Publication date: September 1, 2011Applicant: ANTERIOS, INC.Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang