Patents by Inventor Bong Hyun Chung

Bong Hyun Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11982619
    Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: May 14, 2024
    Assignees: BIONANO HEALTH GUARD RESEARCH CENTER, KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sehoon Kim, Bong Hyun Chung, Youngsun Kim, Kyung Mi Park, Young Hun Seo
  • Publication number: 20210041359
    Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
    Type: Application
    Filed: July 22, 2020
    Publication date: February 11, 2021
    Inventors: Sehoon KIM, Bong Hyun CHUNG, Youngsun KIM, Kyung Mi PARK, Young Hun SEO
  • Patent number: 10761025
    Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: September 1, 2020
    Assignees: BIONANO HEALTH GUARD RESEARCH CENTER, KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sehoon Kim, Bong Hyun Chung, Youngsun Kim, Kyung Mi Park, Young Hun Seo
  • Patent number: 10663459
    Abstract: The present invention relates to a composition for detecting microbial contamination comprising a preparation for detecting nucleases, and a use thereof. A probe for measuring nucleic acid double-stranded nucleases, according to the present invention, may detect the comprehensive nucleic acid degradation capability of nucleases, whereby it is possible to quickly and precisely detect and quantify live microorganisms in a sample in a simple manner. Moreover, since the probe of the present invention is characterized in that signals of fluorescence consistently increase; is capable of measuring live microorganisms; and consists of a double-stranded nucleic acid, the probe is excellent for storage in a kit or a cartridge. As such, it is expected that the probe of the present invention may be used to easily and simply measure and compare the degree of contamination of microorganisms in an environment.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: May 26, 2020
    Assignee: Haesung Bio Co., Ltd.
    Inventors: Kyoung Sook Park, Bong Hyun Chung, Kyung Jin Lee, Byung Kwon Kim, So Yeon Yi, Jung Sun Kwon, Ui Jin Lee, Seong U. Kim, Ho Jae Lee
  • Patent number: 10634674
    Abstract: The present invention relates to a probe for detecting bacteria using a peptidoglycan-binding protein, and a method for preparing the same. Also, the present invention relates to a method for detecting bacteria using the probe. The probe for detecting bacteria according to the present invention can specifically detect bacteria. That is, the probe according to the present invention can clearly distinguish between yeast and bacteria and can detect both Gram-negative and Gram-positive bacteria, and thus is expected to be usable in various fields as a universal probe for detecting bacteria. Further, use of the probe allows bacteria to be detected by identifying only fluorescence development without an additional enzymatic treatment, thereby enabling a simple and quick bacterial detection. In particular, the probe is expected to be effectively usable in the food industry where quick bacterial detection is required.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: April 28, 2020
    Assignee: Haesung Bio Co., Ltd.
    Inventors: Bong Hyun Chung, Eun Kyung Lim, Kyoung Sook Park, Jong Min Choi, Seong U. Kim, Heejun Lee
  • Publication number: 20190033302
    Abstract: The present invention relates to a composition for detecting microbial contamination comprising a preparation for detecting nucleases, and a use thereof. A probe for measuring nucleic acid double-stranded nucleases, according to the present invention, may detect the comprehensive nucleic acid degradation capability of nucleases, whereby it is possible to quickly and precisely detect and quantify live microorganisms in a sample in a simple manner. Moreover, since the probe of the present invention is characterized in that signals of fluorescence consistently increase; is capable of measuring live microorganisms; and consists of a double-stranded nucleic acid, the probe is excellent for storage in a kit or a cartridge. As such, it is expected that the probe of the present invention may be used to easily and simply measure and compare the degree of contamination of microorganisms in an environment.
    Type: Application
    Filed: April 7, 2016
    Publication date: January 31, 2019
    Inventors: Kyoung Sook Park, Bong Hyun Chung, Kyung Jin Lee, Byung Kwon Kim, So Yeon Yi, Jung Sun Kwon, Ui Jin Lee
  • Publication number: 20180292317
    Abstract: A method for detecting biomaterial by means of a dye having a linear upconversion fluorescent property is provided. The method includes the steps of: i) preparing a fluorophore having a linear upconversion fluorescent property; ii) reacting the fluorophore and biomaterial to obtain a reaction complex thereof; iii) exciting the reaction complex by means of a light source having a longer wavelength than the maximum light-emitting wavelength of the fluorophore; and iv) detecting and measuring the light-emitting signal having a shorter wavelength than the wavelength of the excited light emitted from the excited reaction complex. A system and a kit for detecting biomaterial using a dye having a linear upconversion fluorescent property are also provided.
    Type: Application
    Filed: May 16, 2016
    Publication date: October 11, 2018
    Inventors: Sehoon KIM, Bong Hyun CHUNG, Youngsun KIM, Kyung Mi PARK, Young Hun SEO
  • Publication number: 20180080933
    Abstract: The present invention relates to a probe for detecting bacteria using a peptidoglycan-binding protein, and a method for preparing the same. Also, the present invention relates to a method for detecting bacteria using the probe. The probe for detecting bacteria according to the present invention can specifically detect bacteria. That is, the probe according to the present invention can clearly distinguish between yeast and bacteria and can detect both Gram-negative and Gram-positive bacteria, and thus is expected to be usable in various fields as a universal probe for detecting bacteria. Further, use of the probe allows bacteria to be detected by identifying only fluorescence development without an additional enzymatic treatment, thereby enabling a simple and quick bacterial detection. In particular, the probe is expected to be effectively usable in the food industry where quick bacterial detection is required.
    Type: Application
    Filed: April 7, 2016
    Publication date: March 22, 2018
    Inventors: Bong Hyun Chung, Eun Kyung Lim, Kyoung Sook Park, Jong Min Choi
  • Patent number: 9914757
    Abstract: Provided is a methionyl tRNA synthase (MRS) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein G variant using same and, more particularly, to an MRS variant in which alanine at the position of 12th is substituted with glycine, leucine at the position of 13th by serine, tyrosine at the position of 260th by phenylalanine, isoleucine at the position of 297th by valine, and histidine at the position of 301st by leucine from the N-terminal of the amino acid sequence of a wild-type Escherichia coli methionyl tRNA synthase. The MRS variant effectively confirms the biosynthesis of a photomethionine (pM)-labeled target protein and thus can be utilized for the biosynthesis of a pM-labeled target protein.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: March 13, 2018
    Assignee: Korean Research Institute of Bioscience and Biotechnology
    Inventors: Myung Kyu Lee, Bong Hyun Chung, Jeong Hee Moon, Ga Bi Lee
  • Patent number: 9617543
    Abstract: A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a carrier for an anionic substance useful fix therapy and the like; are provided. The polymer is a sugar chain-containing polymer which is a cationic polymer comprising an amine, which polymer comprises N-acetylglucosamine bound thereto. The polymer preferably has a disulfide bond. The polymer preferably has a structure in which polyethyleneimine is linked via a disulfide bond.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: April 11, 2017
    Assignees: SOMAR CORP., KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun Chung, Hirohiko Ise, Toshihiro Akaike, Sun-Jung Kim
  • Patent number: 9487596
    Abstract: The present invention relates to a novel compound isolated from Quamoclit sp., and more particularly to a novel compound isolated from Quamoclit sp. and a composition for preventing or treating diabetes and its complications comprising the compound as an active ingredient. The novel compound isolated from Quamoclit sp. according to the present invention has excellent effects on lowering blood sugar, promoting insulin secretion, inhibiting VEGF expression, and so on. Thus, the present invention not only functions to prevent or treat diabetes and its complications, but also functions to promote treatment effects when treated together with conventional diabetes medicines.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: November 8, 2016
    Assignee: NANOBIOTECH CO., LTD.
    Inventors: Bong Hyun Chung, So Yeon Yi, Ui Jin Lee
  • Publication number: 20160200777
    Abstract: Provided is a methionyl tRNA synthase (MRS) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein G variant using same and, more particularly, to an MRS variant in which alanine at the position of 12th is substituted with glycine, leucine at the position of 13th by serine, tyrosine at the position of 260th by phenylalanine, isoleucine at the position of 297th by valine, and histidine at the position of 301st by leucine from the N-terminal of the amino acid sequence of a wild-type Escherichia coli methionyl tRNA synthase. The MRS variant effectively confirms the biosynthesis of a photomethionine (pM)-labeled target protein and thus can be utilized for the biosynthesis of a pM-labeled target protein.
    Type: Application
    Filed: May 29, 2014
    Publication date: July 14, 2016
    Applicant: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Myung Kyu Lee, Bong Hyun Chung, Jeong Hee Moon, Ga Bi Lee
  • Publication number: 20160130293
    Abstract: The present invention provides a novel compound isolated from a plant of the genus Quamoclit and a method for preparing a novel compound isolated from a plant of the genus Quamoclit through chemical synthesis, and relates to a novel compound and a composition containing the novel compound as an active ingredient for preventing or treating diabetes and diabetic complications. The compound derived from a plant of the genus Quamoclit and the composition containing the compound as an active ingredient according to the present invention have an excellent effect of promoting insulin secretion, thereby exhibiting efficacies in preventing or treating diabetes and the resulting various complications.
    Type: Application
    Filed: May 26, 2014
    Publication date: May 12, 2016
    Applicant: KOREA RESEARCH INSTITUTE BIOSCIENCE
    Inventors: Bong Hyun CHUNG, Ui Jin LEE, So Yeon YI
  • Patent number: 9326940
    Abstract: The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 3, 2016
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Myung Kyu Lee, Abbas Mokhtarieh Amir, Bong Hyun Chung, Jong Min Choi
  • Publication number: 20150246088
    Abstract: Disclosed are a pharmaceutical composition for treating diabetes and its complications, containing a Quamoclit angulata extract, and more particularly to a Quamoclit angulata extract, a pharmaceutical composition for preventing or treating diabetes and its complications, a pharmaceutical composition for preventing or delaying aging, and a pharmaceutical composition for preventing or treating cancer, which contain the Quamoclit angulata extract. The compositions of the invention exhibit excellent effects on blood glucose lowering, promotion of insulin secretion, reduction of proteinuria, and reduction of lenticular opacity. Thus, the pharmaceutical compositions have excellent effects on the prevention or treatment of diabetes and its complications.
    Type: Application
    Filed: May 14, 2015
    Publication date: September 3, 2015
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun CHUNG, Moon II KIM, So Yeon YI, Ui Jin LEE, Kyoungsook PARK, Pan Kee BAE
  • Patent number: 9079837
    Abstract: A simple and easy method is described for preparing a water-soluble fluorescent fullerene derivative with strong fluorescence and hydrophilicity, by mixing fullerene and a ligand containing a terminal hydroxyl group in a first solvent and reacting the mixture in the presence of a catalyst. Such preparation method enables the intensity and wavelength of fluorescence to be easily controlled depending on the amount of fullerene and the type of catalyst that are utilized. The prepared fluorescent fullerene derivative contains a biocompatible ligand, and thus is useful as a biological fluorescent dye. As a result of its fluorescence and excellent solubility in solvent, the fluorescent fullerene derivative is useful in biological, medical, nanotechnology, and other fields.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: July 14, 2015
    Assignee: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun Chung, Jin Young Jeong
  • Publication number: 20150148527
    Abstract: A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a carrier for an anionic substance useful fix therapy and the like; are provided. The polymer is a sugar chain-containing polymer which is a cationic polymer comprising an amine, which polymer comprises N-acetylglucosamine bound thereto. The polymer preferably has a disulfide bond. The polymer preferably has a structure in which polyethyleneimine is linked via a disulfide bond.
    Type: Application
    Filed: May 27, 2014
    Publication date: May 28, 2015
    Applicants: SOMAR Corp., KOREAN RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Bong Hyun CHUNG, Hirohiko ISE, Toshihiro AKAIKE, Sun-Jung KIM
  • Patent number: 9022997
    Abstract: Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: May 5, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Nyeon Sik Eum
  • Publication number: 20140295567
    Abstract: The present invention relates to a method for detecting nucleic acid using intercalator-conjugated metal nanoparticles. More particularly, the present invention relates to a method which involves applying a sample containing a target nucleic acid to a DNA chip having a substrate with a DNA probe fixed thereon, reacting metal nanoparticles in which intercalators coupled with a double helix nucleic acid are conjugated, and reacting a metal enhancing solution to thereby amplify the sizes of the metal nanoparticles and detect the target nucleic acid using the unaided eye. The method for detecting nucleic acid according to the present invention uses intercalator-conjugated metal nanoparticles, and thus enables detection of nucleic acid using the unaided eye without any other equipment.
    Type: Application
    Filed: July 26, 2012
    Publication date: October 2, 2014
    Applicant: INTELLECTUAL DISCOVERY CO., LTD.
    Inventors: Bong Hyun Chung, Sang Gyu Kim, Hyeon Min Jo
  • Patent number: 8785598
    Abstract: Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a water-miscible organic solvent, and easily made into a nano-sized particle and solubilized under a low energy condition, for example, by simple stirring. The coenzyme Q10 may be dispersion-stabilized by an amino acid or protein. The coenzyme Q10 is formed in a nano-sized particle and solubilized, an absorption rate may be increased and simultaneously deliver the amino acid and protein with the nanoparticle. Thus, the coenzyme Q10 nanoparticle can be effectively used in food, cosmetics and medicine.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 22, 2014
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Bong Hyun Chung, Jung Hyun Han