Patents by Inventor Boning Gao

Boning Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue factor compositions and kits for coagulation and tumor treatment
    Patent number: 7951356
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: May 31, 2011
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao
  • Combined tissue factor methods for coagulation and tumor treatment
    Patent number: 7101557
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: September 5, 2006
    Assignee: Board of Regents The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao
  • Calcium channel proteins
    Patent number: 6979724
    Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (?2?) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: December 27, 2005
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, The Board of Regents of the University of Texas System
    Inventors: Michael Isaac Lerman, Farida Latif, Ming-Hui Wei, Fuh-Mei Duh, John Dorrance Minna, Yoshitaka Sekido, Boning Gao
  • Combined tissue factor methods for coagulation and tumor treatment
    Publication number: 20030232753
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
    Type: Application
    Filed: February 27, 2003
    Publication date: December 18, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao
  • Calcium channel compositions and methods of use thereof
    Publication number: 20030044911
    Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (&agr;2&dgr;) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.
    Type: Application
    Filed: April 5, 2002
    Publication date: March 6, 2003
    Inventors: Michael Isaac Lerman, Farida Latif, Ming-Hui Wei, Fuh-Mei Duh, John Dorrance Minna, Yoshitaka Sekido, Boning Gao
  • Calcium channel compositions and methods of use thereof
    Patent number: 6441156
    Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (&agr;2&dgr;) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: August 27, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Isaac Lerman, Farida Latif, Ming-Hui Wei, Fuh-Mei Duh, John Dorrance Minna, Yoshitaka Sekido, Boning Gao
  • Tissue factor methods and compositions for coagulation and tumor treatment
    Patent number: 6156321
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVIIa activators.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: December 5, 2000
    Assignee: Board Of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao
  • Combined tissue factor and chemotherapeutic methods and compositions for coagulation and tumor treatment
    Patent number: 6132729
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulation-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVII activators.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: October 17, 2000
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao
  • Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment
    Patent number: 6132730
    Abstract: The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulation-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa (FVIIa) or FVII activators.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: October 17, 2000
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip E. Thorpe, Steven W. King, Boning Gao