Abstract: The present disclosure provides for a micro-needle device (100, 200, 300, 400) that includes a micro-needle array (102, 202, 302, 402) and a liquid connection port (104, 204, 304, 404). The micro-needle array includes a base (106, 206, 306, 406), a sidewall (108, 208, 308, 408) and a top (110, 210, 310, 410), where the base includes two or more of an elongate micro-needle (112, 212, 312, 412) having an interior surface (114, 214, 314, 414) defining an opening 8116, 216, 316, 416) through the elongate micro-needle. The base has a first major surface (118, 218, 318, 418) and a second major surface (120, 220, 320, 420) through which the opening of the elongate micro-needle passes to provide a passage across the base. The top has an interior surface (122, 222, 322, 422) and the sidewall has an interior surface (126, 226, 326, 426), where the interior surface of the side wall, the interior surface of the top and the first major surface of the base define a volume (130, 230, 330, 430).

Abstract: A microneedle applicator. The applicator can include a microneedle array, a microneedle array holder, and an actuator movable between a first position and a second position to cause the microneedle array holder to move, respectively, between a retracted position and an extended position. The applicator can further include a first biasing element configured to bias the actuator in the first position, and a counter assembly, or mechanism, configured to count a number of times the microneedle array holder is moved between the retracted position and the extended position (or the number of times the actuator is moved from the first position to the second position). In some embodiments, the counter assembly can include the actuator and first biasing element.

Abstract: A hybrid electro-optics correlator comprises a first spatial light modulator for displaying a number of reference images, and a second spatial light modulator for separately displaying a target image. The target and reference images are optically jointly Fourier transformed to produce a joint power spectrum that is detected by a first detector and stored in a computer. Target-only and reference-only power spectra, corresponding to Fourier transforms of the target and reference images, respectively, are digitally subtracted from the joint power spectrum by the computer. The result is a modified power spectrum. The modified power spectrum is displayed by the first spatial light modulator, and is optically Fourier transformed to produce a cross-correlation pattern that is detected by the first detector. Cross-correlation peaks are identified within the cross-correlation pattern, and maximum cross-correlation peak values are compared with verification values in a uniqueness comparison scheme.