Abstract: Aspects of the methods include volumetrically imaging testicular tissue by optical coherence tomography to identify a testicular tissue location that is likely to contain sperm; and m-mode scanning using optical coherence tomography the identified testicular location to determine whether sperm are at least likely to be present at the location. Methods may further include harvesting sperm from the location, e.g., for use in in vitro fertilization. Also provided are devices and systems for practicing the methods.

Abstract: A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electro-magnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information of the portion of the sample, may be obtained. At least one weight function can be applied to the depth information and/or the lateral information so as to generate resulting information. Further, a surface position, a lateral position and/or a depth position of the portion of the sample may be ascertained based on the resulting information.

Abstract: A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electro-magnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information of the portion of the sample, may be obtained. At least one weight function can be applied to the depth information and/or the lateral information so as to generate resulting information. Further, a surface position, a lateral position and/or a depth position of the portion of the sample may be ascertained based on the resulting information.

Abstract: Exemplary embodiments of apparatus, methods and systems according to the present disclosure can be provided for optical frequency domain imaging (e.g., partially fiber-based) to obtain information associated with an anatomical structure or a sample. For example, it is possible to provide at least one first electro-magnetic radiation, where a frequency of radiation associated with the first electro-magnetic radiation(s) varies over time. In addition, it is possible to separate at least one portion of a radiation which is (i) the first electro-magnetic radiation(s) and/or (ii) at least one further radiation into second and third radiations having difference orthogonal states, and to apply at least one first characteristic to the second radiation and at least one second characteristic to at least one third radiation. The first and second characteristics can be different from one another.

Abstract: A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electromagnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information of the portion of the sample, may be obtained. At least one weight function can be applied to the depth information and/or the lateral information so as to generate resulting information. Further, a surface position, a lateral position and/or a depth position of the portion of the sample may be ascertained based on the resulting information.