Patents by Inventor Boris M. Seletsky

Boris M. Seletsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC PAD4 INHIBITORS
    Publication number: 20230167131
    Abstract: The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 1, 2023
    Inventors: Kumaravel Selvakumar, Venkatram Paidi, Srinivasan Thangathirupathy, Vijaya Kumar Cm, Tirupathi Rao Alajangi, Mallikarjun Reddy Sura, Krishna Mahadevu, Ramesh Kumar Sistla, Piyush Agarwal, Arul Mozhi Subbiah Karuppiah, Jalathi S. Nair, Ooha Morampudi, Manoranjan Panda, Joseph A. Tino, Robert J. Cherney, John V. Duncia, Daniel S. Gardner, T. G. Murali Dhar, Audrey Graham Ross, Paul E. Gormisky, Xiao Zhu, Boris M. Seletsky, Alyssa H. Antropow, Deqiang Niu, Zhengdong Zhu, Guobin Miao, Julio Herman Cuervo
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20140309174
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 16, 2014
    Applicant: Eisai Co., Ltd
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Deazapurines and uses thereof
    Patent number: 8691814
    Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: April 8, 2014
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jane Daun, Heather A. Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, André Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris M. Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 8633224
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: January 21, 2014
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20120309938
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 3, 2012
    Publication date: December 6, 2012
    Applicant: EISAI CO., LTD.
    Inventors: James J. KOWALCZYK, Galina KUZNETSOV, Shawn SCHILLER, Boris M. SELETSKY, Mark SPYVEE, Hu YANG
  • Methods and compositions for use in treating cancer
    Patent number: 8148554
    Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: April 3, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Boris M. Seletsky, Melvin J. Yu, Wanjun Zheng
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 8129407
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 6, 2012
    Assignee: Eisai Inc.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Methods and compositions for use in treating cancer
    Patent number: 8097648
    Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 17, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Bruce A. Littlefield, Murray J. Towle, Boris M. Seletsky, Melvin J. Yu, Wanjun Zheng
  • METHODS AND COMPOSITIONS FOR USE IN TREATING CANCER
    Publication number: 20110172446
    Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions.
    Type: Application
    Filed: August 12, 2010
    Publication date: July 14, 2011
    Inventors: Bruce A. Littlefield, Boris M. Seletsky, Murray J. Towle, Melvin J. Yu, Wanjun Zheng
  • DEAZAPURINES AND USES THEREOF
    Publication number: 20110105427
    Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 5, 2011
    Inventors: Jane Daun, Heather A. Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, André Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris M. Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • METHOD OF MAKING IMIDAZOAZEPINONE COMPOUNDS
    Publication number: 20110065916
    Abstract: A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.
    Type: Application
    Filed: November 26, 2008
    Publication date: March 17, 2011
    Inventors: Mark Spyvee, Boris M. Seletsky, Shawn Schiller, Francis Fang
  • Deazapurines and uses thereof
    Patent number: 7868002
    Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: January 11, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jane Daun, Heather A. Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, André Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris M. Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20100063095
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 11, 2010
    Inventors: James J. KOWALCZYK, Galina KUZNETSOV, Shawn SCHILLER, Boris M. SELETSKY, Mark SPYVEE, Hu YANG
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7585976
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: September 8, 2009
    Assignee: Eisai Co., Ltd.
    Inventors: Silvio A. Campagna, Francis G. Fang, James J. Kowalczyk, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • ENANTIOMERICALLY ENRICHED IMIDAZOAZEPINONE COMPOUNDS
    Publication number: 20090197867
    Abstract: The present invention provides an enantiomerically pure compound of Formula I: along with pharmaceutical formulations containing the same and methods of use thereof.
    Type: Application
    Filed: November 14, 2008
    Publication date: August 6, 2009
    Inventors: Mark Spyvee, Christina J. Shaffer, Boris M. Seletsky, Shawn Schiller, Jia Liu, Xiang-Yi Li, Qian Chen, Roch Boivin
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 7528152
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: May 5, 2009
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin Derivatives and Uses Thereof
    Publication number: 20080108820
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: September 22, 2004
    Publication date: May 8, 2008
    Inventors: Silvio A. Campagna, Francis G. Fang, James J. Kowalczyk, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Deazapurines and uses thereof
    Patent number: 7314936
    Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: January 1, 2008
    Assignee: Eisai Co., Ltd.
    Inventors: Jane Daun, Heather A. Davis, Bruce DeCosta, Fabian Gusovsky, Ieharu Hishinuma, Yimin Jiang, Toshihiko Kaneko, Kouichi Kikuchi, Seiichi Kobayashi, André Lescarbeau, Xiang-Yi Li, Kenzo Muramoto, Norihito Ohi, Marc Pesant, Boris M. Seletsky, Motohiro Soejima, Mark Spyvee, Lynda Tremblay, Ye Yao, Hiromitsu Yokohama, Yan (Janet) Zhao, Wanjun Zheng
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7192972
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: March 20, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7064211
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: June 20, 2006
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang