Patents by Inventor Boris Steipe

Boris Steipe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining an analyte
    Patent number: 7700371
    Abstract: The present invention relates to a method for determining an analyte in a sample. According to the method of the present invention, a probe is transferred from a stamp member onto an analyte that is bound to a support member. The present invention is particularly suitable for microarrays.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: April 20, 2010
    Assignee: Arrowhead Research Corporation
    Inventors: Kerstin Blank, Katrin Spinnler, Thao Mai, Filipp Oesterhelt, Ilka Gilbert, Boris Steipe, Hermann Gaub, Christian Albrecht, Gunnar Brink
  • Method for determining an analyte
    Publication number: 20050084855
    Abstract: The present invention relates to a method for determining an analyte in a sample. According to said method, a probe is transferred from a stamp member onto an analyte that is bound to a support member. The invention is particularly suitable for microarrays. The invention also relates to an apparatus for performing said method.
    Type: Application
    Filed: May 31, 2002
    Publication date: April 21, 2005
    Inventors: Kerstin Blank, Katrin Spinnler, Thao Mai, Filipp Oesterhelt, Ilka Gilbert, Boris Steipe, Hermann Gaub, Christian Albrecht, Gunnar Brink
  • Process for modifying the stability of antibodies
    Patent number: 6262238
    Abstract: Process for the production of a functional immunoglobulin or functional derivative or fragment thereof with an improved stability in a eukaryotic or prokaryotic organism by transformation with an expression vector which contains a recombinant gene which codes for the said immunoglobulin derivative or fragment which is characterized in that a modified gene is used which contains at least one codon which is substituted compared to the unmodified gene and codes for a more frequent amino acid. In this way it is also possible to produce active antibodies free of disulfide bridges. In a modification of the process it is possible to selectively destabilize antibodies.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: July 17, 2001
    Assignee: Roche Diagnostic, GmbH
    Inventors: Boris Steipe, Stefan Steinbacher
  • Process for improving the stability of antibodies
    Patent number: 5854027
    Abstract: A process for improving the stability of an antibody or fragment thereof is disclosed. A gene encoding for an amino acid sequence of a variable domain of an antibody or fragment thereof to be modified is provided, and the amino acid sequence of the gene is compared with one of consensus tables 1-6. At least one codon of each pair of codons in the gene, which pair together code for disulfide bridge-forming cysteines, are modified so that all disulfide bridges present in the antibody as produced in a eukaryotic cell are absent from the modified antibody as produced in the method. At least one additional codon in the gene which codes for an amino acid other than a disulfide bridge-forming cysteine is also modified. A prokaryotic microorganism is transformed with the modified gene and additional variable domain DNA, and the modified antibody or fragment thereof is expressed in the prokaryotic microorganism.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: December 29, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Boris Steipe, Stefan Steinbacher