Patents by Inventor Boyce E. Collins
Boyce E. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9555114Abstract: A method of controlled in vivo drug delivery is provided. A porous silicon matrix having pores sized and configured to admit to trap and then release a predetermined molecular complex with a predetermined dose-time profile is selected. The matrix contains the predetermined molecular complex so that the predetermined molecular complex is disposed within the pores of the porous silicon matrix. The matrix is introduced into a human body. The drug releases according the dose-time profile. The introduction can be via transdermal introduction, intramuscular injection, intravenous introduction, surgical implantation, inhalation, and oral ingestion.Type: GrantFiled: September 19, 2014Date of Patent: January 31, 2017Assignee: The Regents of the University of CaliforniaInventors: Michael J. Sailor, Guarav Abbi, Boyce E. Collins, Keiki-Pua S. Dancil
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Patent number: 8852447Abstract: A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.Type: GrantFiled: August 21, 2012Date of Patent: October 7, 2014Assignee: The Regents of the University of CaliforniaInventors: Michael J. Sailor, Gaurav Abbi, Boyce E. Collins, Keiki-Pua S. Dancil
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Patent number: 8274643Abstract: A method for simultaneously detecting and separating a target analyte such as a protein or other macromolecule that includes providing a porous silicon matrix on the silicon substrate, exposing the porous silicon matrix to an environment suspect of containing the target analyte, observing optical reflectivity of the porous silicon matrix; and correlating the changes in the silicon substrate to the target analyte.Type: GrantFiled: March 5, 2004Date of Patent: September 25, 2012Assignee: The Regents of the University of CaliforniaInventors: Michael J. Sailor, Gaurav Abbi, Boyce E. Collins, Keiki-Pua S. Dancil
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Patent number: 7814652Abstract: A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias.Type: GrantFiled: July 25, 2008Date of Patent: October 19, 2010Assignee: BioScale, Inc.Inventors: Colby Bellew, Boyce E. Collins, Kelvin Liu
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Publication number: 20090074951Abstract: A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias.Type: ApplicationFiled: July 25, 2008Publication date: March 19, 2009Applicant: BioScale, Inc.Inventors: Colby Bellew, Boyce E. Collins, Kelvin Liu
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Patent number: 7312046Abstract: A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.Type: GrantFiled: February 25, 2004Date of Patent: December 25, 2007Assignee: The Regents of the University of CaliforniaInventors: Vicki I. Chin, Sangeeta N. Bhatia, Michael J. Sailor, Boyce E. Collins
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Publication number: 20040171143Abstract: The invention is a nanoporous silicon bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by perfusion of the nanoporous silicon support with fluid. Bioreactors may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. Additionally, the bioreactors are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.Type: ApplicationFiled: February 25, 2004Publication date: September 2, 2004Inventors: Vicki I. Chin, Sangeeta N. Bhatia, Michael J. Sailor, Boyce E. Collins
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Patent number: 6734000Abstract: A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients such as by perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that provides cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The support is sufficiently robust that it may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.Type: GrantFiled: October 12, 2001Date of Patent: May 11, 2004Assignee: Regents of the University of CaliforniaInventors: Vicki I. Chin, Sangeeta N. Bhatia, Michael J. Sailor, Boyce E. Collins
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Publication number: 20040043423Abstract: A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias.Type: ApplicationFiled: March 19, 2003Publication date: March 4, 2004Applicant: Molecular ReflectionsInventors: Colby Bellew, Boyce E. Collins, Kelvin Liu
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Publication number: 20020072116Abstract: The invention is a nanoporous silicon bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by perfusion of the nanoporous silicon support with fluid. Bioreactors may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. Additionally, the bioreactors are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.Type: ApplicationFiled: October 12, 2001Publication date: June 13, 2002Inventors: Sangeeta N. Bhatia, Vicki I. Chin, Michael J. Sailor, Boyce E. Collins