Patents by Inventor Bozidar Djordjevic

Bozidar Djordjevic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of assaying sensitivity of cancer stem cells to therapeutic modalities
    Patent number: 9410944
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: August 9, 2016
    Assignee: The Research Foundation for The State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • METHODS OF ASSAYING SENSITIVITY OF CANCER STEM CELLS TO THERAPEUTIC MODALITIES
    Publication number: 20150132792
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Applicant: The Research Foundation for The State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • Methods of assaying sensitivity of cancer stem cells to therapeutic modalities
    Patent number: 8936938
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: January 20, 2015
    Assignee: The Research Foundation of State University of New York
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • Methods of Assaying Sensitivity of Cancer Stem Cells to Therapeutic Modalities
    Publication number: 20100062481
    Abstract: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem cells from the patient. By the methods of the present invention it is possible to treat individual cancer stem cells presented in tumor cells. Methods of detecting and enumerating cancer stem cells in hybrid spheroids comprised of fibroblasts and tumor cells are also provided by the present invention. The present invention also contemplates a method for drug and other treatment development, wherein the effects of a drug or combination of drugs or other treatments are determined on the individual patient's cancer stem cells.
    Type: Application
    Filed: March 31, 2008
    Publication date: March 11, 2010
    Inventors: Christopher S. Lange, Bozidar Djordjevic, Marvin Z. Rotman
  • Carcinogenicity testing system
    Patent number: 6020146
    Abstract: The present invention is directed to an in vitro method for detecting the presence of carcinogenic agents.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: February 1, 2000
    Assignee: The Research Foundation State University of New York
    Inventor: Bozidar Djordjevic
  • Predictive assay for tumor control
    Patent number: 5023172
    Abstract: An in vitro method for determining clonogenicity of and measuring the effect of physical (such as radiation or heat) or chemical treatment on mammalian test cells, including normal and tumor test cells. The method comprises encasing the test cells in agglomerates of non-proliferating, but metabolically active, feeder cells which are capable of forming spheroids. The resulting mixed (hybrid) multicellular spheroids provide an in vivo-like environment for the entrapped test cells. Test cells are subjected to treatment either before or after incorporation into spheroids, and the effect of such treatment is then evaluated from the colony forming ability of spheroids containing test cells.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: June 11, 1991
    Assignee: The Research Foundation of State University of New York
    Inventor: Bozidar Djordjevic