Abstract: This disclosure provides scalable methods of synthesizing highly pure substituted carboxylic acids. One or more embodiments of the present disclosure relate to methods of synthesizing 2,2-dimethylbutanoic acid.

Abstract: Provided herein, in certain embodiments, are compounds of Formula I: or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).

Abstract: A filter element has first and second subelements providing increased media providing improved performance and packaging options. The first and second subelements provide first and second flow paths in parallel with each other along designated flow path portions.

Abstract: A filter element has first and second subelements providing increased media providing improved performance and packaging options. The first and second subelements provide first and second flow paths in parallel with each other along designated flow path portions.

Abstract: Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated with one or more of human PPAR alpha, gamma, or delta (“hPPARs”) comprising administration of a therapeutically effective amount of a compound of formula (1), are disclosed.

Abstract: A filter filters fluid flowing along an axial flow direction and includes a plurality of concentric cylindrical pleated filter elements having a common axis. A plurality of annular radial gaps between filter elements provide additional flow axially through the filter, providing equalized flow and reducing restriction. In further embodiments, a central filter element is concentrically surrounded by a cylindrical pleated outer filter element and provides additional flow axially therethrough.

Abstract: A filter filters fluid flowing along an axial flow direction and includes a plurality of concentric cylindrical pleated filter elements having a common axis. A plurality of annular radial gaps between filter elements provide additional flow axially through the filter, providing equalized flow and reducing restriction. In further embodiments, a central filter element is concentrically surrounded by a cylindrical pleated outer filter element and provides additional flow axially therethrough.

Abstract: A filter (200) filters fluid flowing along an axial flow direction (14) and includes a plurality of panels (206, 208, 240, 242) of pleated filter elements (44), each filter element having a plurality of pleats defined by wall segments (50) extending along a transverse direction (210) between first and second sets of pleat tips at first and second sets of axially extending bend lines (46, 48), the transverse direction (210) being perpendicular to the axial direction (14). Each of the panels (206, 208, 240, 242) extends along a lateral direction (212) perpendicular to the axial direction (14) and perpendicular to the transverse direction (210). The wall segments (50) extend axially between upstream and downstream ends (52, 54), and define axial flow channels (55) therebetween which are alternately sealed at the upstream and downstream ends.

Abstract: A filter (200) filters fluid flowing along an axial flow direction (14) and includes a plurality of panels (206, 208, 240, 242) of pleated filter elements (44), each filter element having a plurality of pleats defined by wall segments (50) extending along a transverse direction (210) between first and second sets of pleat tips at first and second sets of axially extending bend lines (46, 48), the transverse direction (210) being perpendicular to the axial direction (14). Each of the panels (206, 208, 240, 242) extends along a lateral direction (212) perpendicular to the axial direction (14) and perpendicular to the transverse direction (210). The wall segments (50) extend axially between upstream and downstream ends (52, 54), and define axial flow channels (55) therebetween which are alternately sealed at the upstream and downstream ends.