Patents by Inventor Braden Roach

Braden Roach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced production of paclitaxel and taxanes by cell cultures of species
    Patent number: 8338143
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: December 25, 2012
    Assignee: Phyton Holdings, LLC
    Inventors: Venkataraman Bringi, Prakash Kadkade, Christopher Prince, Braden Roach
  • ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES
    Publication number: 20080108115
    Abstract: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T.
    Type: Application
    Filed: August 9, 2007
    Publication date: May 8, 2008
    Applicant: DFB BIOTECH, INCORPORATED
    Inventors: Venkataraman Bringi, Prakash Kadkade, Christopher Prince, Braden Roach
  • Use of indanoyl amide to stimulate secondary metabolism in Taxus sp.
    Publication number: 20050221456
    Abstract: The invention is directed to a method for the production of taxanes by culturing suspension cells of Taxus sp. in a nutrient medium that comprises an indanoyl amino acid. The indanoyl amino acid may be added in batch mode or in a feed stream at any time of the culturing. In particular, synthetic compounds 6-Ethyl-indanoyl-isoleucine, 6-Bromoindanoyl isoleucine and 1-oxo-indane-carboxy-(L)-Isoleucine-methyl ester amide (1-OII) have been found to increase taxane production from Taxus cell cultures.
    Type: Application
    Filed: February 14, 2005
    Publication date: October 6, 2005
    Applicant: Phyton Biotech, Inc.
    Inventors: Venkatesh Srinivasan, Jennifer Alford, Harald Heckenmuller, Braden Roach
  • Enhanced production of taxol and taxanes by cell cultures of taxus species
    Patent number: 5407816
    Abstract: This invention is directed to methods for the enhanced production and recovery of taxol and taxanes by cell cultures of Taxus species.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: April 18, 1995
    Assignee: Phyton Catalytic, Inc.
    Inventors: Venkataraman Bringi, Prakash G. Kadkade, Christopher L. Prince, Barry F. Schubmehl, Eugene J. Kane, Braden Roach