Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Conductive thick film compositions compatible to aluminum nitride, alumina and silicon nitride substrates for microelectronic circuit application. The conductive thick film composition includes first copper powder, second copper powder, and glass component. The conductive thick film composition further includes CU2O, Ag, and at least one metal element selected from Ti, V, Zr, Mn, Cr, Co, and Sn. After firing, the conductive thick film composition exhibit improved sheet resistivity, and improved adhesion with underlying substrate.

Abstract: A sintered machinable glass-ceramic is provided. The machinable glass-ceramic is formed by mixing phyllosilicate material having a sheet structure, with a glass fit and firing the mixture at relatively low temperatures to sinter the phyllosilicate, while maintaining the sheet-like morphology of the phyllosilicate and its associated cleaving properties. The sintered machinable glass-ceramic can be machined with conventional metal working tools and includes the electrical properties of the phyllosilicate. Producing the sintered machinable glass-ceramic does not require the relatively high-temperature bulk nucleation and crystallization needed to form sheet phyllosilicate phases in situ.

Abstract: An opening structure including opening methods and elements to fracture a glass ampoule in a safe, secure, and friendlier manner at a specific point on the ampoule, which allows the ampoule to retain in place its substantial structure, allowing less glass fragments from the ampoule's breakage to obstruct the smooth, consistent, and speedy flow of the ampoule's substance to the opening structure's dispenser/applicator.

Abstract: A method selects a phase shift profile to be applied to a programmable optical phase shift modulator having an array of pixels. A base stepped phase shift profile for the modulator is selected such that when applied to the modulator, the base stepped phase shift profile allows the modulator to function as a blazed grating steering an optical beam through a prescribed angle. The base stepped phase shift profile has a plurality of segments each extending over a given number of the pixels defining a linear array of pixels. Each segment has first and last pixels in the linear array of pixels. Variations in minimum and maximum luminosity levels among the segments of the base stepped phase shift profile are reduced so that any changes to a slope of each segment arising from reducing the variations in the minimum and maximum luminosity level is maintained below a given amount.

Abstract: A method selects a phase shift profile to be applied to a programmable optical phase shift modulator having an array of pixels. A base stepped phase shift profile for the modulator is selected such that when applied to the modulator, the base stepped phase shift profile allows the modulator to function as a blazed grating steering an optical beam through a prescribed angle. The base stepped phase shift profile has a plurality of segments each extending over a given number of the pixels defining a linear array of pixels. Each segment has first and last pixels in the linear array of pixels. Variations in minimum and maximum luminosity levels among the segments of the base stepped phase shift profile are reduced so that any changes to a slope of each segment arising from reducing the variations in the minimum and maximum luminosity level is maintained below a given amount.

Abstract: The present document describes systems and methods that authorize client resources such as computers, servers, computing appliances, and virtual machines to access online services provided by an online service provider. To authorize a client resource, a client submits a registration request on behalf of the client resource to an authorization service provided by the service provider. The authorization service returns an activation code to the client. The activation code may expire after an amount of time, or upon first use. The client provides the activation code to an agent running on the client resource. The agent establishes communication with the authorization service, and upon providing the activation code to the authorization service, receives an authorization token that can be used by the client resource to access online services in accordance with security roles or permissions specified with the registration request.

Abstract: A passivation glass coating composition is provided for forming a fired passivation glass layer on a semiconductor substrate having p-n junction. The passivation glass coating composition includes a glass component that is lead free, cadmium free, alkali metal oxides free, and colored transition metal oxides (i.e. metal oxides of V, Fe, Co, Ni, Cr, Cu, Mn) free. The glass component includes bismuth based glasses, and provides a firing temperature range of 500° C. to 900° C., and controlled devitrification. Once fired to a semiconductor device, the fired passivation glass layer provides exceptional device performance including no cracking of the fired passivation glass layer, excellent thermal expansion matching to silicon, good chemical resistance to acid and base, and improved device performance.

Abstract: A passivation glass coating composition is provided for forming a fired passivation glass layer on a semiconductor substrate having p-n junction. The passivation glass coating composition includes a glass component that is lead free, cadmium free, alkali metal oxides free, and colored transition metal oxides (i.e. metal oxides of V, Fe, Co, Ni, Cr, Cu, Mn) free. The glass component includes bismuth based glasses, and provides a firing temperature range of 500° C. to 900° C., and controlled devitrification. Once fired to a semiconductor device, the fired passivation glass layer provides exceptional device performance including no cracking of the fired passivation glass layer, excellent thermal expansion matching to silicon, good chemical resistance to acid and base, and improved device performance.

Abstract: The present document describes systems and methods that authorize client resources such as computers, servers, computing appliances, and virtual machines to access online services provided by an online service provider. To authorize a client resource, a client submits a registration request on behalf of the client resource to an authorization service provided by the service provider. The authorization service returns an activation code to the client. The activation code may expire after an amount of time, or upon first use. The client provides the activation code to an agent running on the client resource. The agent establishes communication with the authorization service, and upon providing the activation code to the authorization service, receives an authorization token that can be used by the client resource to access online services in accordance with security roles or permissions specified with the registration request.

Abstract: The present document describes systems and methods that authorize client resources such as computers, servers, computing appliances, and virtual machines to access online services provided by an online service provider. To authorize a client resource, a client submits a registration request on behalf of the client resource to an authorization service provided by the service provider. The authorization service returns an activation code to the client. The activation code may expire after an amount of time, or upon first use. The client provides the activation code to an agent running on the client resource. The agent establishes communication with the authorization service, and upon providing the activation code to the authorization service, receives an authorization token that can be used by the client resource to access online services in accordance with security roles or permissions specified with the registration request.

Abstract: A sintered machinable glass-ceramic is provided. The machinable glass-ceramic is formed by mixing phyllosilicate material having a sheet structure, with a glass fit and firing the mixture at relatively low temperatures to sinter the phyllosilicate, while maintaining the sheet-like morphology of the phyllosilicate and its associated cleaving properties. The sintered machinable glass-ceramic can be machined with conventional metal working tools and includes the electrical properties of the phyllosilicate. Producing the sintered machinable glass-ceramic does not require the relatively high-temperature bulk nucleation and crystallization needed to form sheet phyllosilicate phases in situ.

Abstract: The present document describes systems and methods that authorize client resources such as computers, servers, computing appliances, and virtual machines to access online services provided by an online service provider. To authorize a client resource, a client submits a registration request on behalf of the client resource to an authorization service provided by the service provider. The authorization service returns an activation code to the client. The activation code may expire after an amount of time, or upon first use. The client provides the activation code to an agent running on the client resource. The agent establishes communication with the authorization service, and upon providing the activation code to the authorization service, receives an authorization token that can be used by the client resource to access online services in accordance with security roles or permissions specified with the registration request.

Abstract: A method of monitoring at least one optical wavelength component of a WDM optical signal being routed through a wavelength selective switch (WSS) includes directing an optical wavelength component from a given input port of the WSS to a selected output port with a selected amount of attenuation. A rejected portion of the optical wavelength component giving rise to the selected amount of attenuation is directed to an optical monitor associated with another output port of the WSS. A power level of the optical wavelength component is determined by pre-calibrating a proportionality between the power level of the wavelength component and the power level of the rejected portion that is directed to the optical monitor.

Abstract: A method of monitoring at least one optical wavelength component of a WDM optical signal being routed through a wavelength selective switch (WSS) includes directing an optical wavelength component from a given input port of the WSS to a selected output port with a selected amount of attenuation. A rejected portion of the optical wavelength component giving rise to the selected amount of attenuation is directed to an optical monitor associated with another output port of the WSS. A power level of the optical wavelength component is determined by pre-calibrating a proportionality between the power level of the wavelength component and the power level of the rejected portion that is directed to the optical monitor.

Abstract: A magnet structure for particle acceleration includes at least two coils that include a continuous path of superconducting material [e.g., niobium tin (Nb3Sn) having an A15-type crystal structure] for electric current flow there through. The coils can be mounted in a bobbin, which together with the coils form a cold-mass structure. The coils are cooled to their superconducting temperatures via cryocoolers. Radial-tension members are coupled with the cold-mass structure to keep it centered, such that it remains substantially symmetrical about a central axis and is not pulled out of alignment by magnetic forces acting thereon. A wire can be wrapped around the coils, and a voltage can be applied thereto to quench the coils to prevent their operation of the coils in a partially superconducting condition, which may otherwise cause damage thereto. A magnetic yoke surrounds the cold-mass structure and includes a pair of poles that, in part, define an acceleration chamber there between.