Abstract: A guide wire having dual coil on core configuration. The guide wire has a core wire with distal and proximal ends or segments wherein two coils are tandomly disposed on its distal end. The more proximally-disposed of the distal coils is multifilar having from 4 to 15 filars all wound in one direction. The multifilar coil comprises a super elastic material. The more distal of the distally-disposed coils comprises a radiopaque material, the core wire terminating with an atraumatic tip. A guide wire of this invention is particularly well suited to navigation of the neuroanatomy.