Patents by Inventor BRADLEY J. HEDBERG

BRADLEY J. HEDBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VAR2CSA-drug conjugates
    Patent number: 10675355
    Abstract: VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: June 9, 2020
    Assignees: VAR2 PHARMACEUTICALS APS, ZYMEWORKS INC.
    Inventors: James R. Rich, John Babcook, Ali El-Salanti, Mads Daugaard, Madeleine Dahlback, Bradley J. Hedberg, Geoffrey C. Winters, Alexander L. Mandel, Elyse Marie Josée Bourque, Tom Han Hsiao Hsieh
  • VAR2CSA-DRUG CONJUGATES
    Publication number: 20180117163
    Abstract: VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 3, 2018
    Applicants: ZYMEWORKS INC., VAR2 PHARMACEUTICALS APS
    Inventors: James R. RICH, John BABCOOK, Ali EL-SALANTI, Mads DAUGAARD, Madeleine DAHLBACK, Bradley J. HEDBERG, Geoffrey C. WINTERS, Alexander L. MANDEL, Elyse Marie Josée BOURQUE, Tom Han Hsiao HSIEH
  • VAR2CSA-DRUG CONJUGATES
    Publication number: 20170246310
    Abstract: VAR2CSA-drug conjugates having biological activity are disclosed. Methods associated with preparation and use of such conjugates, as well as pharmaceutical compositions comprising such conjugates, are also disclosed.
    Type: Application
    Filed: December 29, 2014
    Publication date: August 31, 2017
    Applicants: ZYMEWORKS INC., VAR2 PHARMACEUTICALS APS
    Inventors: James R. RICH, John BABCOOK, Ali EL-SALANTI, Mads DAUGAARD, Madeleine DAHLBACK, Bradley J. HEDBERG, Geoffrey C. WINTERS, Alexander L. MANDEL, Elyse Marie Josée BOURQUE, Tom Han Hsiao HSIEH
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 9522876
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 20, 2016
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, Alexander L. Mandel, Bradley J. Hedberg, John Babcook, James R. Rich, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20140315954
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4 and R5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).
    Type: Application
    Filed: March 14, 2014
    Publication date: October 23, 2014
    Inventors: Geoffrey C. WINTERS, Alexander L. Mandel, BRADLEY J. HEDBERG