Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A system and method enables operation of a game, such as a fantasy sports game. The system includes various software and hardware components such as one or more user stations, a network and a game platform. The game platform enables creation of a plurality of user teams. Each user team may include, for example, a plurality of real teams as its members. Performance of the real teams is monitored to determine relative performance of the user teams.

Abstract: The invention is a message distribution system that can deliver a single message to a large number of people with a single act using a group of computer servers. The preferred embodiment requires the user to establish an account using a website and enter a contact list. The contact list can include both email addresses and telephone numbers. When the user wishes to send a message, at a later time, the user contacts the group of computer servers by a telephone number or email address. The user records a message on the servers and the server sends the messages to all email addresses and telephone numbers on the contact list for that user. Other embodiments include procedures to confirm the validity of the email addresses and telephone numbers and to confirm the delivery of messages to the email address and telephone numbers on the contact list.