Patents by Inventor Bradley R. Borlee

Bradley R. Borlee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for the biocontrol of disease-transmitting mosquitoes and their eggs using horizontally transferable symbiotic bacteria to deliver pathogen specific interfering RNA polynucleotides
    Patent number: 11396653
    Abstract: The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel paratransgenic system configured to deliver one or more inhibitory RNA molecules to pathogen/disease-transmitting organisms. In a preferred embodiment, the invention may include one or more genetically engineered symbiotic bacteria configured to persist throughout the life-cycle of a mosquito and deliver one or more interfering RNA molecules to pathogen/disease-transmitting mosquitoes.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: July 26, 2022
    Assignees: PEBBLE LABS INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Richard Sayre, Jiannong Xu, Bradley R. Borlee, Konstantinos Lymperopoulos, Rebekah Kading, William Black, Kenneth Olson, Carol Blair
  • Novel System for the Biocontrol of Disease-Transmitting Mosquitoes and Their Eggs Using Horizontally Transferable Symbiotic Bacteria to Deliver Pathogen Specific Interfering RNA Polynucleotides
    Publication number: 20190093110
    Abstract: The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel paratransgenic system configured to deliver one or more inhibitory RNA molecules to pathogen/disease-transmitting organisms. In a preferred embodiment, the invention may include one or more genetically engineered symbiotic bacteria configured to persist throughout the life-cycle of a mosquito and deliver one or more interfering RNA molecules to pathogen/disease-transmitting mosquitoes.
    Type: Application
    Filed: July 10, 2018
    Publication date: March 28, 2019
    Inventors: Richard Sayre, Jiaannong Xu, Bradley R. Borlee, Konstantinos Lymperopoulos
  • Method for modulating microbial quorum sensing
    Patent number: 8063108
    Abstract: The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: November 22, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo E. Handelsman, Bradley R. Borlee
  • Method For Modulating Microbial Quorum Sensing
    Publication number: 20100216835
    Abstract: The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
    Type: Application
    Filed: February 25, 2010
    Publication date: August 26, 2010
    Inventors: Jo E. Handelsman, Bradley R. Borlee