Patents by Inventor Bradley W. Caprathe

Bradley W. Caprathe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine Derivatives
    Publication number: 20100120858
    Abstract: The invention relates to compounds of Formula (I) and pharmaceutically acceptable acid addition salts thereof, wherein *, X1, X2, R5A, R5B, R6, R7, and R8 are as defined in the specification; pharmaceutical compositions; therapeutic combinations; and methods of treating diseases and disorders.
    Type: Application
    Filed: August 13, 2007
    Publication date: May 13, 2010
    Inventors: Bradley W. Caprathe, Rocco D. Gogliotti, Rex A. Jennings, Lloyd J. Simons
  • Method of imaging amyloid deposits
    Patent number: 6001331
    Abstract: The present invention provides a method of imaging amyloid deposits and radiolabeled compounds useful in imaging amyloid deposits. The invention also provides a method of delivering a therapeutic agent to amyloid deposits, a method of inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of determining a compound's ability to inhibit aggregation of amyloid proteins.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: December 14, 1999
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, John L. Gilmore, Sheryl J. Hays, Juan C. Jaen, Harry LeVine, III
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5409931
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: February 4, 1994
    Date of Patent: April 25, 1995
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
    Patent number: 5346911
    Abstract: Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds which are azabicyclo[2.2.1]oximes, azabicyclo[2.2.2]oximes, azabicyclo[2.2.1]amines, azabicyclo[2.2.2]amines, azabicyclo[3.2.1]oximes, and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 3 to 7 carbon atoms are disclosed.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: September 13, 1994
    Assignee: Warner-Lambert Company
    Inventors: Corinne E. Augelli-Szafran, Stephen D. Barrett, Bradley W. Caprathe, Adam A. Galan, Juan C. Jaen, David J. Lauffer, Walter H. Moos, Michael R. Pavia, Kathryn B. Sanders, Haile Tecle, Anthony J. Thomas
  • Pyrazoloquinazolone derivatives as neurotrophic agents
    Patent number: 5342942
    Abstract: Pyrazolo[5,1-b]quinazoline compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds, and methods for treating neurodegenerative disorders, tumors of neuronal origin, inflammation, allergy, and pain, and methods for screening compounds that interact with the neurotrophic receptors using said compositions are disclosed.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: August 30, 1994
    Assignee: Warner-Lambert Company
    Inventors: Juan C. Jaen, Bradley W. Caprathe
  • Fused pyridazinoquinazolone derivatives as neurotrophic agents
    Patent number: 5340808
    Abstract: Fused pyridazinoquinazoline compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating neurodegenerative disorders using said compositions are disclosed.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: August 23, 1994
    Assignee: Warner Lambert Company
    Inventors: Juan C. Jaen, Bradley W. Caprathe
  • 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
    Patent number: 5314896
    Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: May 24, 1994
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5198443
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: March 30, 1993
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted 1,2,3,6-tetrahydropyridines as central nervous system agents
    Patent number: 5120748
    Abstract: Substituted 1,2,3,6-tetrahydropyridines are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: June 9, 1992
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted cyclohexanols as central nervous system agents
    Patent number: 5047406
    Abstract: Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: September 10, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted tetrahydrobenzothiazoles as dopaminergic agents
    Patent number: 4988699
    Abstract: Substituted tetrahydrobenzothiazoles are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: March 14, 1989
    Date of Patent: January 29, 1991
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Substituted cyclohexenes as central nervous system agents
    Patent number: 4975445
    Abstract: Substituted cyclohexenes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: December 4, 1990
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • Substituted cyclohexanols as central nervous system agents
    Patent number: 4957921
    Abstract: Substituted cyclohexanols are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: September 18, 1990
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Sarah J. Smith, Lawrence D. Wise
  • 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents
    Patent number: 4935424
    Abstract: Substituted 2-aminothiazoles are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: May 27, 1988
    Date of Patent: June 19, 1990
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
    Patent number: 4803203
    Abstract: Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virture of their dopamine autoreceptor agonist activity. Methods of preparation, pharmeceutical compositions, and methods for treating psychoses, such a schizophrenia, are also described.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: February 7, 1989
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Horace A. DeWald, Juan C. Jaen, Lawrence D. Wise
  • Hetero [f] fused carbocyclic pyridines as dopaminergic agents
    Patent number: 4762843
    Abstract: Hetero [f] fused carbocyclic pyridines are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: August 9, 1988
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
    Patent number: 4704390
    Abstract: Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor agonist activity. Methods of preparation, pharmaceutical compositions, and methods for treating psychoses, such as schizophrenia, are also described.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: November 3, 1987
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Horace A. DeWald, Juan C. Jaen, Lawrence D. Wise