Patents by Inventor Brahm Goldstein

Brahm Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods Of Administering High Concentrations Of Nitric Oxide
    Publication number: 20230256190
    Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
    Type: Application
    Filed: April 19, 2023
    Publication date: August 17, 2023
    Applicant: Mallinckrodt Hospital Products IP Unlimited Company
    Inventors: Brahm Goldstein, Douglas Stuart Greene
  • Methods of administering high concentrations of nitric oxide
    Patent number: 11660416
    Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: May 30, 2023
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Brahm Goldstein, Douglas Stuart Greene
  • USE OF ADAMTS13 FOR TREATING, AMELIORATING AND/OR PREVENTING VASO-OCCLUSIVE CRISIS IN SICKLE CELL DISEASE, ACUTE LUNG INJURY AND/OR ACUTE RESPIRATORY DISTRESS SYNDROME
    Publication number: 20220047688
    Abstract: The disclosure provides compositions and methods for treating, ameliorating, and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD). The disclosure also provides compositions and methods for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The disclosure provides A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member-13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating, and/or preventing the VOC, or for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS.
    Type: Application
    Filed: November 1, 2021
    Publication date: February 17, 2022
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Bruce EWENSTEIN, Brahm GOLDSTEIN, Bernhard MAJER, Paolo ROSSATO, Friedrich SCHEIFLINGER, Marietta TURECEK
  • Use of ADAMTS13 for treating, ameliorating and/or preventing vaso-occlusive crisis in sickle cell disease, acute lung injury and/or acute respiratory distress syndrome
    Patent number: 11191818
    Abstract: The disclosure provides compositions and methods for treating, ameliorating, and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD). The disclosure also provides compositions and methods for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The disclosure provides A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member-13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating, and/or preventing the VOC, or for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: December 7, 2021
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Bruce Ewenstein, Brahm Goldstein, Bernhard Majer, Paolo Rossato, Friedrich Scheiflinger, Marietta Turecek
  • Methods Of Administering High Concentrations Of Nitric Oxide
    Publication number: 20200171264
    Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 4, 2020
    Applicant: Mallinckrodt Hospital Products IP Limited
    Inventors: Brahm Goldstein, Douglas Stuart Greene
  • Methods of administering high concentrations of nitric oxide
    Patent number: 10556086
    Abstract: Methods of administering therapeutic gases containing high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also, methods of administering a therapeutic gas containing nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods can also include intermittent administration of nitric oxide pulses.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 11, 2020
    Assignee: Mallinckrodt Hospital IP Limited
    Inventors: Brahm Goldstein, Douglas Stuart Greene
  • USE OF ADAMTS13 FOR TREATING, AMELIORATING AND/OR PREVENTING VASO-OCCLUSIVE CRISIS IN SICKLE CELL DISEASE, ACUTE LUNG INJURY AND/OR ACUTE RESPIRATORY DISTRESS SYNDROME
    Publication number: 20190336588
    Abstract: The disclosure provides compositions and methods for treating, ameliorating, and/or preventing a vaso-occlusive crisis (VOC) in a subject suffering from sickle cell disease (SCD). The disclosure also provides compositions and methods for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). The disclosure provides A Disintegrin And Metalloproteinase with Thrombospondin type 1 motif, member-13 (ADAMTS13) or a composition comprising ADAMTS13 for treating, ameliorating, and/or preventing the VOC, or for treating, ameliorating, and/or preventing lung injury in a subject suffering from or at risk of suffering from ALI and/or ARDS.
    Type: Application
    Filed: August 4, 2017
    Publication date: November 7, 2019
    Applicants: BAXALTA INCORPORATED, BAXALTA GMBH
    Inventors: Bruce EWENSTEIN, Brahm GOLDSTEIN, Bernhard MAJER, Paolo ROSSATO, Friedrich SCHEIFLINGER, Marietta TURECEK
  • METHODS OF ADMINISTERING NITRIC OXIDE TO ARTERIAL OR ARTERIALIZED BLOOD
    Publication number: 20180339095
    Abstract: The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 29, 2018
    Inventors: Brahm Goldstein, Jim Potenziano
  • Methods of administering nitric oxide to arterial or arterialized blood
    Patent number: 10052426
    Abstract: The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: August 21, 2018
    Assignee: Mallinckrodt Pharma IP Trading D.A.C.
    Inventors: Brahm Goldstein, Jim Potenziano
  • Methods of Administering Nitric Oxide to Arterial or Arterialized Blood
    Publication number: 20150151034
    Abstract: The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.
    Type: Application
    Filed: May 30, 2013
    Publication date: June 4, 2015
    Inventors: Brahm Goldstein, Jim Potenziano
  • Methods Of Administering High Concentrations Of Nitric Oxide
    Publication number: 20130239962
    Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2000 ppm. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 19, 2013
    Applicant: INO Therapeutics LLC
    Inventor: Brahm Goldstein
  • Methods Of Administering High Concentrations Of Nitric Oxide
    Publication number: 20130239963
    Abstract: Described are methods of administering therapeutic gases comprising high concentrations of nitric oxide, particularly concentrations above 2,000 ppm. The therapeutic gas may be administered at a certain dosing rate, such as less than 166 micrograms of nitric oxide per second. Also described are methods of administering a therapeutic gas comprising nitric oxide to a patient, wherein a dose of nitric oxide is administered from a portable device that includes a delivery system and a mini-cylinder. Methods of intermittent administration of nitric oxide pulses are also described.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 19, 2013
    Applicant: INO Therapeutics LLC
    Inventors: Brahm Goldstein, Douglas Stuart Greene
  • Methods of Using Inhaled Nitric Oxide Gas for Treatment of Acute Respiratory Distress Syndrome
    Publication number: 20120107423
    Abstract: The present invention provides a treatment of acute respiratory distress syndrome (ARDS) using short term dosing of nitric oxide.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 3, 2012
    Applicant: INO Therapeutics LLC
    Inventor: Brahm Goldstein