Abstract: The disclosure provides methods, biomarkers, and kits for determining the prognosis of Zika virus infection in relation to severity of symptoms resulting from effects of the Zika virus infection on bone metabolism, such as arthralgia, osteoporosis, and craniosynostosis. The disclosure further provides treatments for Zika virus infection, in particular for treating arthralgia, osteoporosis, and craniosynostosis.

Abstract: A method and system for accelerated fatigue damage testing of an object excited via an actor, wherein a drive signal is generated and transmitted to the actor, where the acceleration of the object or a mounting base of the actor is measured and supplied to a control system, where a Power Spectral Density (PSD) and a Fatigue Damage Spectrum FDS within the control system are calculated from the measured acceleration, whereby the calculated PSD is compared with a target PSD, whereby the calculated Fatigue Damage Spectrum FDS is compared with a target FDS, whereby a new drive frequency spectrum is calculated based on the comparisons and, one or multiple time domain blocks for the drive signal for a next cycle are generated from the new drive frequency spectrum and transmitted to the actor such that accelerated vibration testing without affecting the failure mode is achieved which provides realistic results.

Abstract: A method and system for accelerated fatigue damage testing of an object excited via an actor, wherein a drive signal is generated and transmitted to the actor, where the acceleration of the object or a mounting base of the actor is measured and supplied to a control system, where a Power Spectral Density (PSD) and a Fatigue Damage Spectrum FDS within the control system are calculated from the measured acceleration, whereby the calculated PSD is compared with a target PSD, whereby the calculated Fatigue Damage Spectrum FDS is compared with a target FDS, whereby a new drive frequency spectrum is calculated based on the comparisons and, one or multiple time domain blocks for the drive signal for a next cycle are generated from the new drive frequency spectrum and transmitted to the actor such that accelerated vibration testing without affecting the failure mode is achieved which provides more realistic results.

Abstract: The invention provides methods for the detection of prion diseases, such as scrapie of sheep, bovine spongiform encephalopathy of cattle, Creutzfeld-Jacob disease of man, whereby aberrant proteins or prion proteins are detected in tissues which can be sampled from live animals.